Molekularne povezave med cirkadianim ritmom in mikro RNA v hepatocelularnem karcinomu by Rok Struna, Jan Tehovnik, Rok Razpotnik, Tadeja Režen

“…Namen študije je bil ugotoviti vpliv transkripcijskih dejavnikov cirkadianega ritma in miRNA na izražanje mRNA in krožnih RNA iz istega genskega lokusa, tj. gena LDLR (LDL receptor). Metode: Poskus smo izvedli na celičnih linijah Hep G2 in Huh7. …”
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LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function by Menno Hoekstra, Suzanne J.A. Korporaal, Ronald J. van der Sluis, Veronica Hirsch-Reinshagen, Andrea E. Bochem, Cheryl L. Wellington, Theo J.C. Van Berkel, Jan Albert Kuivenhoven, Miranda Van Eck

“…In contrast, adrenals of LCAT KO mice show compensatory up-regulation of genes involved in cholesterol synthesis (HMG-CoA reductase; 516%; P < 0.001) and acquisition (LDL receptor; 385%; P < 0.001) and a marked 40–50% lower glucocorticoid response to adrenocorticotropic hormone exposure, endotoxemia, or fasting (P < 0.001 for all). …”
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Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients With Non-syndromic Cleft Palate Only by Renato Assis Machado, Renato Assis Machado, Hercílio Martelli-Junior, Hercílio Martelli-Junior, Silvia Regina de Almeida Reis, Erika Calvano Küchler, Rafaela Scariot, Lucimara Teixeira das Neves, Lucimara Teixeira das Neves, Ricardo D. Coletta

“…The most significantly biological processes and pathways overrepresented in the NSCPO-identified genes were associated with the folic acid metabolism, highlighting the interaction between LDL receptor-related protein 6 (LRP6) and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) that interconnect two large networks. …”
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Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures by Anika Alberts, Annika Klingberg, Leonie Hoffmeister, Anne Kathrin Wessig, Korbinian Brand, Andreas Pich, Konstantin Neumann

“…Among the strongest binding proteins, we unexpectedly found two transmembrane receptors, namely macrophage receptor with collagenous structure (MARCO) and low-density lipoprotein (LDL) receptor (LDLR). We show that recombinant versions of both human and mouse MARCO directly bind to unopsonized MSU and several other disease-associated crystals. …”
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Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer by Daniela Criscuolo, Rosario Avolio, Giovanni Calice, Chiara Laezza, Simona Paladino, Giovanna Navarra, Francesca Maddalena, Fabiana Crispo, Cristina Pagano, Maurizio Bifulco, Matteo Landriscina, Danilo Swann Matassa, Franca Esposito

“…Expression of FDPS and OSC, enzymes involved in cholesterol synthesis, are decreased both in drug-resistant cells and upon TRAP1 silencing, whereas the expression of LDL receptor, the main mediator of extracellular cholesterol uptake, is increased. …”
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Long-term Expression of Apolipoprotein B mRNA-specific Hammerhead Ribozyme via scAAV8.2 Vector Inhibits Atherosclerosis in Mice by Hersharan Nischal, Hua Sun, Yuchun Wang, David A Ford, Ying Cao, Peng Wei, Ba-Bie Teng

“…LDb mice lack both low density lipoproteins (LDL) receptor (Ldlr−/−) and apoB mRNA editing enzyme (Apobec1−/−) genes and develop atherosclerosis spontaneously. …”
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Systemic Amelioration via Curcumin in Rats following Splenectomy: Lipid Profile, Endothelial and Oxidative Damage by Yuksel Altinel, Emin Kose, Aysel Karacaglar, Serdar Demirgan, Volkan Sozer, Guven Ozkaya, Osman Bilgin Gulcicek, Gonul Simsek, Hafize Uzun

“…The primary outcomes; total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), oxidized LDL (ox-LDL) very-low-density lipoprotein (VLDL) and lectin-type oxidized LDL receptor 1 (LOX-1), secondary outcomes: nuclear factor kappa B (NF-кB), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD) were measured. …”
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Reduction of circulating PCSK9 and LDL-C levels by liver-specific knockdown of HNF1α in normolipidemic mice[S] by Vikram Ravindra Shende, Minhao Wu, Amar Bahadur Singh, Bin Dong, Chin Fung Kelvin Kan, Jingwen Liu

“…We developed shRNA adenoviral constructs (Ad-shHNF1α and Ad-shHNF1β) to examine the effects of knockdown of HNF1α or HNF1β on PCSK9 expression and its consequent impact on LDL receptor (LDLR) protein levels in cultured hepatic cells and liver tissue. …”
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Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasi... by Hwang Jong-Hee, Roberts Craig W, Ferguson David JP, Wollmann Robert, Kirisits Michael J, Mayr Thomas, Kasza Kristen, Roberts Fiona, Mui Ernest, Kelly Krystyna A, Ajioka James W, Hermes Gretchen, Trendler Toria, Kennan Richard P, Suzuki Yasuhiro, Reardon Catherine, Hickey William F, Chen Lieping, McLeod Rima

“…Full genome microarrays of brains reflected inflammation causing neuronal damage (Gfap), effects on host cell protein processing (ubiquitin ligase), synapse remodeling (Complement 1q), and also increased expression of PD-1L (a ligand that allows persistent <it>LCMV </it>brain infection) and CD 36 (a fatty acid translocase and oxidized LDL receptor that mediates innate immune response to beta amyloid which is associated with pro-inflammation in Alzheimer's disease). …”
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Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor by Christophe Gardès, Denise Blum, Konrad Bleicher, Evelyne Chaput, Martin Ebeling, Peter Hartman, Corinne Handschin, Hans Richter, G. Martin Benson

“…Also, more-potent and -selective FXR agonists did not affect human or murine apoA-I expression in this model. In LDL receptor-deficient mice and Golden Syrian hamsters, selective FXR agonists did not affect apoA-I expression, whereas in Wistar rats, some even increased apoA-I expression. …”
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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease by Stephan Sachs, Anna Götz, Brian Finan, Annette Feuchtinger, Richard D. DiMarchi, Yvonne Döring, Christian Weber, Matthias H. Tschöp, Timo D. Müller, Susanna M. Hofmann

“…Methods After 8 weeks on western diet, LDL receptor knockout (LDLR-/-) male mice were treated with daily subcutaneous injections of long-acting acylated GIP analog (acyl-GIP; 10nmol/kg body weight) for 28 days. …”
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Diosgenin And 4-Hydroxyisoleucine From Fenugreek Are Regulators Of Genes Involved In Lipid Metabolism In The Human Colorectal Cancer Cell Line SW480 by Maryam Mohammad-Sadeghipour, Mehdi Mahmoodi, Mojgan Noroozi Karimabad, Mohammad Reza Mirzaei, Mohammad Reza Hajizadeh

“…Thus, in this study, we examined the effects of hydroalcoholic extract of fenugreek seeds (HEFS), diosgenin and 4-OH-Ile on the expression of acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), peroxisome proliferator-activated receptor gamma (PPARγ) and low-density lipoprotein (LDL) receptor (LDLR) which are involved in lipid metabolism in SW480 cell line. …”
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Oat attenuate non-alcoholic fatty liver and obesity via inhibiting lipogenesis in high fat-fed rat by Chiung-Huei Peng, Hong-Chou Chang, Mon-Yuan Yang, Chien-Ning Huang, Shing-Jung Wang, Chau-Jong Wang

“…Thirty percent oat markedly reduced lipid synthesis biomarkers FAS, GPAT and HMG CoA reductase, while 15% and 30% oat stimulated expressions of oxidation markers PPARα, CPT-1 and phosphorylated-AMPK. Oat increased LDL receptor, being beneficial for serum lipid-lowering. …”
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Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate by Iryna Sutter, Rebekka Park, Alaa Othman, Lucia Rohrer, Thorsten Hornemann, Markus Stoffel, Olivier Devuyst, Arnold von Eckardstein

“…Apom−/− mice excreted significant amounts of S1P. apoM was detected in the urine of mice with defective tubular endocytosis because of knockout of the LDL receptor-related protein, chloride-proton exchanger ClC-5 (Clcn5−/−), or the cysteine transporter cystinosin. …”
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Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management by Mohd Waiz, Sahir Sultan Alvi, M. Salman Khan

“…PCSK-9 is well reckoned to facilitate the LDL-receptor (LDL-R) degradation and compromised LDL-C clearance leading to the arterial atherosclerotic plaque formation. …”
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Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones by Melissa N. Martinez, Christopher H. Emfinger, Matthew Overton, Salisha Hill, Tara S. Ramaswamy, David A. Cappel, Ke Wu, Sergio Fazio, W. Hayes McDonald, David L. Hachey, David L. Tabb, John M. Stafford

“…These changes were associated with decreased hepatic expression of SR-B1, ABCA1, and LDL receptor, proteins involved in modulating the lipid content of HDL. …”
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Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B by J R McNamara, D M Small, Z Li, E J Schaefer

“…Such conformational changes in apoB may alter exposed epitopes, possibly causing changes in LDL receptor binding affinity and resistance to oxidation.…”
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Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance by Mai K. L. Nguyen, Jaimy Jose, Mohamed Wahba, Marc Bernaus-Esqué, Andrew J. Hoy, Carlos Enrich, Carles Rentero, Thomas Grewal

“…This includes a higher demand for cholesterol, which often coincides with elevated cholesterol uptake from low-density lipoproteins (LDL) and overexpression of the LDL receptor in many cancers. This implies the need for cancer cells to accommodate an increased delivery of LDL along the endocytic pathway to late endosomes/lysosomes (LE/Lys), providing a rapid and effective distribution of LDL-derived cholesterol from LE/Lys to other organelles for cholesterol to foster cancer growth and spread. …”
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Terminalia bellirica Extract Inhibits Low-Density Lipoprotein Oxidation and Macrophage Inflammatory Response in Vitro by Miori Tanaka, Yoshimi Kishimoto, Emi Saita, Norie Suzuki-Sugihara, Tomoyasu Kamiya, Chie Taguchi, Kaoruko Iida, Kazuo Kondo

“…In THP-1 macrophages, TBE treatment resulted in significant decreases of the mRNA expression of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and lectin-like oxidized LDL receptor-1 (LOX-1). TBE also reduced matrix metalloproteinase (MMP)-9 secretion and intracellular reactive oxygen species (ROS) production in THP-1 macrophages. …”
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Gender differences in response to dietary soluble fiber in guinea pigs: effects of pectin, guar gum, and psyllium. by M L Fernandez, M Vergara-Jimenez, A L Romero, S K Erickson, D J McNamara

“…In addition, plasma LDL lowering in animals fed the LC diets was associated with increases in hepatic LDL receptor Bmax values. Effects of fiber on hepatic cholesterol in animals fed HC diets were moderate and hepatic enzymes were not altered to the same extent as in the LC groups. …”
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