Can voluntary exercise improve renal changes in offspring induced by maternal obesity by Chowdhury, Sabiha Sultana, Bahari, Hasnah, Caruso, Vanni, Maloney, Christopher A., Morris, Margaret J.

“…Maternal diet was associated with an upregulation of fatty acid transporter Cd36. Ldl receptor (Ldlr), involved in uptake of fat, was significantly upregulated by both post-weaning HFD and exercise. …”
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Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia by Karim Si-Tayeb, Salam Idriss, Benoite Champon, Amandine Caillaud, Matthieu Pichelin, Lucie Arnaud, Patricia Lemarchand, Cédric Le May, Kazem Zibara, Bertrand Cariou

“…Pravastatin treatment significantly enhanced LDL receptor (LDLR) and PCSK9 mRNA gene expression, as well as PCSK9 secretion and LDL uptake in both control and S127R HLCs. …”
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Associations of LRP5 and MTHFR Gene Variants with Osteoarthritis Prevalence in Elderly Women: A Japanese Cohort Survey Randomly Sampled from a Basic Resident Registry by Nakano M, Yui H, Kikugawa S, Tokida R, Sakai N, Kondo N, Endo N, Haro H, Shimodaira H, Suzuki T, Kato H, Takahashi J, Nakamura Y

“…Fisher’s exact testing revealed significant relationships between the minor T allele of LDL receptor related protein 5 (LRP5) rs3736228 and the prevalence of knee/hip OA and osteoporosis. …”
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Human Lupus Plasma Pro-Atherogenic Effects on Cultured Macrophages Are Not Mitigated by Statin Therapy: A Mechanistic LAPS Substudy by Allison B. Reiss, Hirra A. Arain, Lora J. Kasselman, Heather A. Renna, Juan Zhen, Iryna Voloshyna, Joshua DeLeon, Steven E. Carsons, Michelle Petri

“…<i>Results:</i> Macrophages exposed to plasma from both statin-treated and placebo-treated groups showed a significant decrease in cholesterol efflux proteins ATP binding cassette (ABC) transporters A1 and ABCG1, an increase in 27-hydroxylase, an increase in the LDL receptor and a decrease in intracellular free cholesterol. …”
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Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E by Kenneth C-W. Yu, Yuan Jiang, Wei Chen, Allen D. Cooper

“…When the concentration of remnants was increased to 12 μg of protein per ml, a level at which it has been shown that LDL receptor and LRP are near saturation, the capacity of the wild-type mouse livers to remove chylomicron remnants was decreased to 10–25% per pass, confirming that the removal mechanisms were nearing saturation. …”
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Computational Screening Strategy for Drug Repurposing Identified Niclosamide as Inhibitor of Vascular Calcification by Takeshi Tanaka, Takaharu Asano, Takehito Okui, Shiori Kuraoka, Sasha A. Singh, Masanori Aikawa, Masanori Aikawa, Masanori Aikawa, Elena Aikawa, Elena Aikawa, Elena Aikawa

“…To validate this compound in vivo, LDL receptor (Ldlr)-deficient mice fed a high fat diet were given oral doses of niclosamide (0 or 750 ppm admixed with diet) for 10 weeks. …”
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LRP1 loss in airway epithelium exacerbates smoke-induced oxidative damage and airway remodeling by Itsaso Garcia-Arcos, Sangmi S. Park, Michelle Mai, Roger Alvarez-Buve, Lillian Chow, Huchong Cai, Nathalie Baumlin-Schmid, Christina W. Agudelo, Jennifer Martinez, Michael D. Kim, Abdoulaye J. Dabo, Matthias Salathe, Ira J. Goldberg, Robert F. Foronjy

“…The LDL receptor-related protein 1 (LRP1) partakes in metabolic and signaling events regulated in a tissue-specific manner. …”
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ApoB-75, a truncation of apolipoprotein B associated with familial hypobetalipoproteinemia: genetic and kinetic studies. by ES Krul, KG Parhofer, PH Barrett, RD Wagner, G Schonfeld

“…To determine whether the low concentration of apoB-75 was due to its enhanced LDL-receptor-mediated removal, apoB-75 LDL were isolated from the proband's d 1.063-1.090 g/ml fraction (which contained most of the apoB-75 in his plasma) by chromatography on anti-apoB and anti-apoA-I immunoaffinity columns. …”
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The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice by Fabrizio Pin, Fabrizio Pin, Fabrizio Pin, Joshua R. Huot, Joshua R. Huot, Andrea Bonetto, Andrea Bonetto, Andrea Bonetto, Andrea Bonetto, Andrea Bonetto

“…The improvement of the oxidative metabolism was associated with reduced myosteatosis (i.e., intramuscular fat infiltration) in the C26 bearers receiving MitoQ, despite unchanged muscle LDL receptor expression, therefore suggesting that MitoQ could boost β-oxidation in the muscle tissue and promote a glycolytic-to-oxidative shift in muscle metabolism and fiber composition. …”
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Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs by John R. Burnett, Lisa J. Wilcox, Dawn E. Telford, Sandra J. Kleinstiver, P. Hugh R. Barrett, Roger S. Newton, Murray W. Huff

“…Avasimibe decreased the LDL apoB pool size by 13–57%, largely due to a dose-dependent 25–63% in the LDL apoB production rate. Hepatic LDL receptor mRNA abundances were unchanged, consistent with a marginal decrease in LDL apoB FCRs. …”
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Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis by Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh

“…Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. …”
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CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells by Yaqi Qiu, Yaqi Qiu, Hui Wang, Hui Wang, Qian Guo, Yiwen Liu, Yiqing He, Guoliang Zhang, Cuixia Yang, Cuixia Yang, Yan Du, Feng Gao, Feng Gao

“…Moreover, we revealed that tPA could interact with LDL receptor related protein 1 (LRP1) to activate the downstream NFκB signaling pathway, which in turn facilitate lamellipodia formation. …”
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Development of Immature CD4+CD8+T Cells Into Mature CD4+ T Cells Requires Alpha-1 Antitrypsin as Observed by Treatment in HIV-1 Infected and Uninfected Controls by Cynthia L. Bristow, Cynthia L. Bristow, Sara Ferrando-Martinez, Sara Ferrando-Martinez, Ezequiel Ruiz-Mateos, Manuel Leal, Ronald Winston, Ronald Winston

“…Immune cells are, by default, migratory cells that traverse tissue for the purpose of carrying out recognition and recruitment in pathologic inflammation and infection. Members of the LDL receptor family (LDL-RFMs) interact with human leukocyte elastase on the cell surface (HLE-CS) in complex with the abundant blood protein α1proteinase inhibitor (α1PI, α1-antitrypsin, Alpha-1), a process that induces internalization of aggregated functionally-related receptors, including CD4 and the T cell antigen receptor, while simultaneously promoting cellular locomotion. …”
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Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis by Karen H.Y. Wong, Michal Levy‐Sakin, Walfred Ma, Nina Gonzaludo, Angel C.Y. Mak, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Zoe Grenville, Nicolas Wong, John P. Kane, Pui‐Yan Kwok, Mary J. Malloy, Clive R. Pullinger

“…It is usually caused by homozygous or compound heterozygous functional mutations in the LDL receptor (LDLR). A number of mutations causing FH have been reported in literature and such genetic heterogeneity presents great challenges for disease diagnosis. …”
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Novel Dental Anomaly–associated Mutations in WNT10A Protein Binding Sites by Piranit Kantaputra, Peeranat Jatooratthawichot, Oranuch Tantachamroon, Kamonporn Nanekrungsan, Worrachet Intachai, Bjorn Olsen, Sissades Tongsima, Chumpol Ngamphiw, James R. Ketudat Cairns

“…Objective: WNT/β-catenin signaling is initiated by binding of a WNT protein to a Frizzled (FZD) receptor and a co-receptor, low-density lipoprotein (LDL) receptor-related protein 5 or 6 (LRP5/6). The objective of this study was to find the genetic variants responsible for dental anomalies found in 4 families. …”
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A Systematic Approach to Assess the Activity and Classification of PCSK9 Variants by Kepa B. Uribe, Kevin Chemello, Asier Larrea-Sebal, Asier Benito-Vicente, Unai Galicia-Garcia, Steeve Bourane, Ali K. Jaafar, Gilles Lambert, César Martín

“…Background: Gain of function (GOF) mutations of PCSK9 cause autosomal dominant familial hypercholesterolemia as they reduce the abundance of LDL receptor (LDLR) more efficiently than wild-type PCSK9. …”
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Development of polymeric nanoparticle vaccines for immunostimulation by Basto, Pamela A. (Pamela Antonia)

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A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain by Jean-François Blain, Eric Paradis, Sophie B Gaudreault, Danielle Champagne, Denis Richard, Judes Poirier

“…No change was observed for receptors of the LDL-receptor family or RAP at DPL 2 in the hippocampus but the glia-specific syndecan-4 was found to be significantly upregulated at DPL 2. …”
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Natural Biflavonoids Modulate Macrophage–Oxidized LDL Interaction In Vitro and Promote Atheroprotection In Vivo by Jorge H. Tabares-Guevara, Oscar J. Lara-Guzmán, Oscar J. Lara-Guzmán, Julian A. Londoño-Londoño, Jelver A. Sierra, Yudy M. León-Varela, Rafael M. Álvarez-Quintero, Edison J. Osorio, José R. Ramirez-Pineda, José R. Ramirez-Pineda

“…In biflavonoid-treated macrophages, the surface expression of the oxidized LDL (oxLDL) receptor CD36 was significantly lower than in vehicle-treated macrophages. …”
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The apolipoprotein receptor LRP3 compromises APP levels by Inmaculada Cuchillo-Ibañez, Matthew P. Lennol, Sergio Escamilla, Trinidad Mata-Balaguer, Lucía Valverde-Vozmediano, Inmaculada Lopez-Font, Isidro Ferrer, Javier Sáez-Valero

“…Abstract Background Members of the low-density lipoprotein (LDL) receptor family are involved in endocytosis and in transducing signals, but also in amyloid precursor protein (APP) processing and β-amyloid secretion. …”
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