CD1d deficiency inhibits the development of abdominal aortic aneurysms in LDL receptor deficient mice. by Gijs H M van Puijvelde, Amanda C Foks, Rosemarie E van Bochove, Ilze Bot, Kim L L Habets, Saskia C de Jager, Mariëtte N D Ter Borg, Puck van Osch, Louis Boon, Mariska Vos, Vivian de Waard, Johan Kuiper

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LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway by Iveta Dobreva, Gérard Waeber, Vincent Mooser, Richard W. James, Christian Widmann

“…This activation did not require the recruitment of the LDL receptor (LDLR), because LDLs efficiently stimulated the p38 MAPK pathway in human and mouse fibroblasts lacking functional LDLR, and because receptor-associated protein, an LDLR family antagonist, did not block the LDL-induced p38 activation. …”
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Lipoprotein lipase-mediated uptake of lipoprotein in human fibroblasts: evidence for an LDL receptor-independent internalization pathway by M Fernández-Borja, D Bellido, E Vilella, G Olivecrona, S Vilaró

“…It was previously shown that two different receptors are involved in mediating the LPL effects: heparan sulfate proteoglycans (HSPG) and the low density lipoprotein (LDL) receptor-related protein/alpha 2 macroglobulin receptor (LRP). …”
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Induction of acetyl-LDL receptor activity by phorbol ester in human monocyte cell line THP-1. by D P Via, L Pons, D K Dennison, A E Fanslow, F Bernini

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Isoproterenol decreases LDL receptor expression in rat adipose cells: activation of cyclic AMP-dependent proteolysis by F B Kraemer, V Natu, A Singh-Bist, S Patel, M C Komaromy, S Medicherla, S Azhar, C Sztalryd

“…The low density lipoprotein (LDL) receptor is part of a family of proteins that mediate the uptake of lipoproteins into cells. …”
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Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model by Marumi Ohno, Akemi Kakino, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Tatsuya Sawamura, Hiroshi Kida

“…Also, an increased gene expression of oxidized low-density lipoprotein (LDL) receptor-1 (Olr1), a key molecule in endothelial dysfunction in the progression of atherosclerosis, was detected in the aorta of infected mice. …”
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Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. by Bart Lammers, Ying Zhao, Menno Hoekstra, Reeni B Hildebrand, Dan Ye, Illiana Meurs, Theo J C Van Berkel, Miranda Van Eck

“…Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored.LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCA1/apoE double KO (dKO) mice, their respective single KO's, and wild-type (WT) controls and were challenged with a high-fat/high-cholesterol diet for 9 weeks. …”
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Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice by Ana Paula Garcia Bochi, Guilherme da Silva Ferreira, Vanessa Del Bianco, Paula Ramos Pinto, Letícia Gomes Rodrigues, Mayara da Silva Trevisani, Luzia Naoko Shinohara Furukawa, Kely Cristina Soares Bispo, Alexandre Alves da Silva, Ana Paula Pereira Velosa, Edna Regina Nakandakare, Ubiratan Fabres Machado, Walcy Paganelli Rosolia Teodoro, Marisa Passarelli, Sergio Catanozi

“…This study investigated the efficacy of aerobic exercise training (AET) in the prevention of dyslipidemia, insulin resistance (IR), and atherogenesis induced by severe low-sodium (LS) diet. LDL receptor knockout (LDLR KO) mice were fed a low-sodium (LS) (0.15% NaCl) or normal-sodium (NS; 1.27% NaCl) diet, submitted to AET in a treadmill, 5 times/week, 60 min/day, 15 m/min, for 90 days, or kept sedentary. …”
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Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a] by Jianglin Fan, Mireille Challah, Hiroaki Shimoyamada, Masashi Shiomi, Santica Marcovina, Teruo Watanabe

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Replacement of cysteine at position 46 in the first cysteine-rich repeat of the LDL receptor impairs apolipoprotein recognition. by A Benito-Vicente, K B Uribe, H Siddiqi, S Jebari, U Galicia-Garcia, A Larrea-Sebal, A Cenarro, M Stef, H Ostolaza, F Civeira, L Palacios, C Martin

“…Here we investigated the role of Cys46 located in the first repeat of the LDL receptor binding domain in recognition of apolipoproteins. …”
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Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. by Loukia Katsouri, Spiros Georgopoulos

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LDL receptor-related protein 5 selectively transports unesterified polyunsaturated fatty acids to intracellular compartments by Wenwen Tang, Yi Luan, Qianying Yuan, Ao Li, Song Chen, Stanley Menacherry, Lawrence Young, Dianqing Wu

“…Here, we show that LDL receptor-related protein 5 (LRP5), but not its homolog LRP6, selectively transports unesterified PUFAs into a number of cell types. …”
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Soy milk versus simvastatin for preventing atherosclerosis and left ventricle remodeling in LDL receptor knockout mice by L. Santos, A.P. Davel, T.I.R. Almeida, M.R. Almeida, E.A. Soares, G.J.M. Fernandes, S.F. Magalhães, V.G. Barauna, J.A.D. Garcia

“…In this study, we compared the effects of oral treatment with soy milk and simvastatin on dyslipidemia, left ventricle remodeling and atherosclerotic lesion of LDL receptor knockout mice (LDLr-/-) fed a hyperlipidic diet. …”
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LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice by P.J. Tacken, B. Teusink, M.C. Jong, D. Harats, L.M. Havekes, K. Willems van Dijk, M.H. Hofker

“…Willems van Dijk, and M. H. Hofker. LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice. …”
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Differences in Recycling of Apolipoprotein E3 and E4—LDL Receptor Complexes—A Mechanistic Hypothesis by Meewhi Kim, Ilya Bezprozvanny

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Screening and Identification of ssDNA Aptamers for Low-Density Lipoprotein (LDL) Receptor-Related Protein 6 by Xiaomin Zhang, Ge Yang, Wenjing Liu, Qing Liu, Zhuoran Wang, Kelong Fan, Feng Qu, Yuanyu Huang

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PANDORA-Seq unveils the hidden small noncoding RNA landscape in atherosclerosis of LDL receptor-deficient mice by Rebecca Hernandez, Junchao Shi, Jingwei Liu, Xiuchun Li, Jake Wu, Linlin Zhao, Tong Zhou, Qi Chen, Changcheng Zhou

“…To identify novel sncRNAs associated with atherosclerosis development, LDL receptor-deficient (LDLR−/−) mice were fed a low-cholesterol diet or high-cholesterol diet (HCD) for 9 weeks. …”
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Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mices⃞ by Stefan P.J. Dullens, Ronald P. Mensink, Marjolijn C.E. Bragt, Arie K. Kies, Jogchum Plat

“…Here we present that neither the individual policosanol components (C24, C26, C28, or C30) nor the natural policosanol mixture (all 30 mg/100 g diet) lowered serum cholesterol concentrations in LDL receptor knock-out (LDLr+/−) mice. Moreover, there was no effect on gene expression profiles of LDLr, ABCA1, HMG-CoA synthase 1, and apolipoprotein A-I (apoA-I) in hepatic and small intestinal tissue of female LDLr+/− mice after the 7 week intervention period. …”
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Molecular imaging of atherosclerotic plaque targeted to oxidized LDL receptor LOX-1 using magnetic resonance by Beller George A, Glover David K, Ruiz Mirta, Roy Rene J, Kramer Christopher M, Klibanov Alexander, Patel Amit R, Li Dayuan, Meyer Craig H

Identification of autoantibodies in human plasma recognizing an apoB-100 LDL receptor binding site peptide by Gunilla Nordin Fredrikson, Göran Berglund, Ragnar Alm, Jan-Åke Nilsson, Prediman K. Shah, Jan Nilsson

“…The aim of this study was to test the hypothesis that autoantibodies recognize amino acid sequences in the LDL receptor binding region of apolipoprotein B-100 (apoB-100). …”
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