Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans[S] by Thuc T. Le, Holli M. Duren, Mikhail N. Slipchenko, Chang-Deng Hu, Ji-Xin Cheng

“…We find that the relative expression level of neutral and autofluorescent lipid species can be used to assay the genotype-phenotype relationship of mutant C. elegans with deletions in the genes encoding lipid synthesis transcription factors, LDL receptors, transforming growth factor β receptors, lipid desaturation enzymes, and antioxidant enzymes. …”
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GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation by Steve Poirier, Maya Mamarbachi, Wan-Ting Chen, Amy S. Lee, Gaetan Mayer

“…Clearance of circulating low-density lipoprotein cholesterol (LDLc) by hepatic LDL receptors (LDLR) is central for vascular health. …”
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Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Beyond Lipids: The Role in Oxidative Stress and Thrombosis by Vittoria Cammisotto, Francesco Baratta, Paola G. Simeone, Cristina Barale, Enrico Lupia, Gioacchino Galardo, Francesca Santilli, Isabella Russo, Pasquale Pignatelli

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9), mainly secreted in the liver, is a key regulator of cholesterol homeostasis inducing LDL receptors’ degradation. Beyond lipid metabolism, PCSK9 is involved in the development of atherosclerosis, promoting plaque formation in mice and human, impairing the integrity of endothelial monolayer and promoting the events that induce atherosclerosis disease progression. …”
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PCSK9: A Key Target for the Treatment of Cardiovascular Disease (CVD) by Saeideh Sobati, Amir Shakouri, Mahdi Edalati, Daryoush Mohammadnejad, Reza Parvan, Javad Masoumi, Jalal Abdolalizadeh

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a vital modulator of low-density lipoprotein cholesterol (LDL-C) , is raised in hepatocytes and released into plasma where it binds to LDL receptors (LDLR), leading to their cleavage. PCSK9 adheres to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR which is confirmed by crystallography. …”
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Sex difference in circulating PCSK9 and its clinical implications by Fang Jia, Si-Fan Fei, De-Bing Tong, Cong Xue, Jian-Jun Li

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) is a proprotein convertase that increases plasma low-density lipoprotein cholesterol (LDL-C) levels by triggering the degradation of LDL receptors (LDLRs). Beyond the regulation of circulating LDL-C, PCSK9 also has direct atherosclerotic effects on the vascular wall and is associated with coronary plaque inflammation. …”
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Clinical utility of evolocumab in the management of hyperlipidemia: patient selection and follow-up by Dixon DL, Buckley LF, Trankle CR, Kadariya D, Abbate A

“…Evolocumab is a fully humanized monoclonal antibody that inhibits PCSK9, an enzyme that binds to LDL receptors and prevents them from recycling to the hepatocyte surface. …”
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Design and assembly of a nanoparticle, antibody, phthalocyanine scaffold for intracellular delivery of photosensitizer to human papillomavirus-transformed cancer cells by Elvin Peter Chizenga, Heidi Abrahamse

“…AbstractIn photodynamic therapy (PDT), internalization and uptake of the photosensitizer (PS) by the cells is a passive process that relies on the enhanced permeability and retention (EPR) effect of tumour tissues due to their vasculature, increased LDL receptors, and decreased lymphatic drainage in vivo. …”
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Epigenetic Regulatory Effect of Exercise on Glutathione Peroxidase 1 Expression in the Skeletal Muscle of Severely Dyslipidemic Mice. by Albert Nguyen, Natacha Duquette, Maya Mamarbachi, Eric Thorin

“…The aim of our study was to determine whether in the early stages of atherogenesis, in young severely dyslipidemic mice lacking LDL receptors and overexpressing human ApoB100 (LDLR-/-; hApoB+/+), exercise regulates differentially the expression of antioxidant enzymes by DNA methylation in the skeletal muscles that consume high levels of oxygen and thus generate high levels of reactive oxygen species. …”
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Apolipoprotein B: its role in the control of fibroblast cholesterol biosynthesis and in the regulation of its own binding to cellular receptors. by R B Shireman, W R Fisher

“…Accordingly, fibroblast cholesterol synthesis and the number of functional LDL receptors are not suppressed by the binding of the apoprotein to the receptor, and the known role of apoB remains that of transporting cholesterol in plasma and delivering it to the cell. …”
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Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Cri... by Helena Gylling, Timo E. Strandberg, Petri T. Kovanen, Piia Simonen

“…They reduce cholesterol absorption so that less cholesterol is transported to the liver, and the expression of LDL receptors is upregulated. Ultimately, LDL-C concentrations are reduced on average by 9–12% by consuming 2–3 g of plant stanol esters per day. …”
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Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice by Sandra K. Erickson, Steven R. Lear, Sean Deane, Sandrine Dubrac, Sandra L. Huling, Lien Nguyen, Jaya S. Bollineni, Sarah Shefer, Hideyuki Hyogo, David E. Cohen, Benjamin Shneider, Ephraim Sehayek, Meena Ananthanarayanan, Natarajan Balasubramaniyan, Fredrick J. Suchy, Ashok K. Batta, Gerald Salen

“…Both male and female cyp7A1-deficient mice had decreased hepatic LDL receptors, unchanged hepatic cholesterol synthesis, increased intestinal cholesterol synthesis and bile acid transporters, and decreased fecal bile acids but increased fecal sterols. …”
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Anacetrapib, a New CETP Inhibitor: The New Tool for the Management of Dyslipidemias? by Theodosios D. Filippatos, Anastazia Kei, Moses S. Elisaf

“…A new CETP inhibitor, anacetrapib, substantially increases HDL cholesterol and apolipoprotein (Apo) AI levels with a profound increase of large HDL2 particles, but also pre-β HDL particles, decreases LDL cholesterol levels mainly due to increased catabolism of LDL particles through LDL receptors, decreases lipoprotein a (Lp(a)) levels owing to a decreased Apo (a) production and, finally, decreases modestly triglyceride (TRG) levels due to increased lipolysis and increased receptor-mediated catabolism of TRG-rich particles. …”
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Effects of specific inhibition of sterol biosynthesis on the uptake and utilization of low density lipoprotein cholesterol by HepG2 cells. by SR Panini, GT Everson, TA Spencer

“…These data demonstrate that a specific inhibition of the sterol branch of isoprenoid biosynthetic pathway in hepatic cells by TMD is sufficient to induce the expression of LDL receptors and that the cholesterol delivered by LDL is available for normal metabolic purposes of the cell.…”
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Modification of the core lipids of low density lipoproteins produces selective alterations in the expression of apoB-100 epitopes. by M Kinoshita, ES Krul, G Schonfeld

“…The conformations of apoB on the LDL particles then were examined a) by probing epitope expression and b) by examining interactions between LDL and LDL-receptors in cultured human fibroblasts. During incubations with VLDL and lipid transfer proteins, the diameters of LDL particles decreased; the percentage composition of LDL triglycerides increased three-to fivefold; concomitantly, cholesteryl esters decreased. …”
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Clinical efficacy and safety of evolocumab for low-density lipoprotein cholesterol reduction by Henry CA, Lyon RA, Ling H

“…By inactivating PCSK9, evolocumab upregulates LDL receptors causing increased catabolism of LDL-C and the consequent reduction of LDL-C levels in blood. …”
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pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes by Elena Makoveichuk, Peter Cherepanov, Susanne Lundberg, Åke Forsberg, Gunilla Olivecrona

“…Binding of pH6-Ag to macrophages was not dependent on the presence of LDL receptors. Treatment of the cells with Triton X-100 or with methyl-β-cyclodextrin indicated that the binding of pH6-Ag was partly dependent on lipid rafts.We suggest that interaction of pH6-Ag with apoB-containing lipoproteins could be of importance for the establishment of Y. pestis infections. …”
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Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR by Yan Wang, Yongcheng Huang, Helen H. Hobbs, Jonathan C. Cohen

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types. Here we used genetic and pharmacological inhibitors to define the pathways involved in PCSK9-mediated LDLR degradation. …”
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Inclisiran: A New Promising Agent in the Management of Hypercholesterolemia by Constantine E. Kosmas, Alba Muñoz Estrella, Andreas Sourlas, Delia Silverio, Elizabeth Hilario, Peter D. Montan, Eliscer Guzman

“…The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9), a serine protease which binds to the low-density lipoprotein (LDL) receptors and targets the receptors for lysosomal degradation, offered an additional route through which plasma LDL-cholesterol (LDL-C) levels can be controlled. …”
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Effect of Oxidized Low-Density Lipoprotein on Head and Neck Squamous Cell Carcinomas by Nadège Kindt, Fabrice Journé, Stéphane Carlier, Anne Trelcat, Alessandro Scalia, Sven Saussez

“…We investigated two oxLDL receptors, CD36 and Lox-1, using immunofluorescence. …”
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Moxonidine Increases Uptake of Oxidised Low-Density Lipoprotein in Cultured Vascular Smooth Muscle Cells and Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Yutang Wang, Dinh Tam Nguyen, Jack Anesi, Ahmed Alramahi, Paul K. Witting, Zhonglin Chai, Abdul Waheed Khan, Jason Kelly, Kate M. Denton, Jonathan Golledge

“…Moxonidine increased the expression of LDL receptors and the lipid efflux transporter ABCG1. …”
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