Di’ao Xinxuekang Capsule Improves the Anti-Atherosclerotic Effect of Atorvastatin by Downregulating the SREBP2/PCSK9 Signalling Pathway by Jiyi Liang, Jiyi Liang, Wei Li, Honglin Liu, Xiaofen Li, Chuqiao Yuan, Wenjun Zou, Liping Qu, Liping Qu

“…However, statins can also upregulate proprotein convertase subtilisin/kexin type 9 (PCSK9), which in turn might limits the cholesterol-lowering effect of statins through the degradation of LDL receptors (LDLR). Di’ao Xinxuekang (DXXK) capsule, as a well-known traditional Chinese herbal medicine for the prevention and treatment of coronary heart disease, can alleviate lipid disorders and ameliorate atherosclerosis in atherosclerosis model mice and downregulate the expression of PCSK9. …”
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Appropriateness of Dyslipidemia Management Strategies in Post-Acute Coronary Syndrome: A 2023 Update by Fabiana Lucà, Fabrizio Oliva, Carmelo Massimiliano Rao, Maurizio Giuseppe Abrignani, Antonio Francesco Amico, Stefania Angela Di Fusco, Giorgio Caretta, Irene Di Matteo, Concetta Di Nora, Anna Pilleri, Roberto Ceravolo, Roberta Rossini, Carmine Riccio, Massimo Grimaldi, Furio Colivicchi, Michele Massimo Gulizia

“…Although novel lipid-lowering drugs have different targets, the result is always the overexpression of LDL receptors (LDL-R), increased uptake of LDL-C, and lower LDL-C plasmatic levels. …”
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Impact of biobanks on research outcomes in rare diseases: a systematic review by Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang

“…For example, research of low-density lipoprotein (LDL)-receptors in the rare disease known as familial hypercholesterolemia led to the discovery of statins, a drug therapy that is now used routinely to prevent heart disease. …”
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The effect of kefir and peppermint extract (Mentha pipperita) extract in drinking water on performance, lipid profiles, thyroid hormones and testosterone hormone of Japanese quail by Khalil Mirzadeh, Amin Kazemizadeh, Zarbakht Ansari Pirsaraei

“…Peppermint also accelerates LDL catabolism by increasing liver LDL receptors. In addition, Mentha pipperita inhibits the activity of the enzyme fatty acid synthase (FAS) and increases the beta oxidation of fatty acids, thereby effectively reducing fat storage. …”
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