Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. by Roman Covarrubias, Ashley J Wilhelm, Amy S Major

“…In this study, we investigated whether a structurally related receptor to the LDLr, known as LDL receptor-related protein (LRP), plays a role in iNKT cell activation. …”
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Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult men by Volek Jeff S, McGrane Mary M, Torres-Gonzalez Moises, Mutungi Gisella, Fernandez Maria

“…HMG-CoA reductase and the LDL receptor (LDL-r) are involved in this regulation and are also ubiquitously expressed in all major tissues. …”
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Yellow Wine Polyphenolic Compounds Inhibit Matrix Metalloproteinase-2, -9 Expression and Improve Atherosclerotic Plaque in LDL-Receptor–Knockout Mice by Xiaoya Zhai, Jufang Chi, Weiliang Tang, Zheng Ji, Fei Zhao, Chengjian Jiang, Haitao Lv, Hangyuan Guo

“…Six-week-old male LDL-receptor–knockout mice were treated with high-fat diet to establish the mouse model with atherosclerosis. …”
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Relative importance of the LDL receptor and scavenger receptor class B in the β-VLDL-induced uptake and accumulation of cholesteryl esters by peritoneal macrophages by Nicole Herijgers, Miranda Van Eck, Suzanne J.A. Korporaal, Peter M. Hoogerbrugge, Theo J.C. Van Berkel

“…We investigated the mechanism of β-very low density lipoprotein (β-VLDL)-induced foam cell formation derived from peritoneal macrophages from control mice and low density lipoprotein (LDL) receptor-deficient mice to elucidate the role of the LDL receptor in this process. …”
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Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice by Sérgio Catanozi, Jussara C. Rocha, Marisa Passarelli, Maria L. Guzzo, Cleiton Alves, Luzia N.S. Furukawa, Valéria S. Nunes, Edna R. Nakandakare, Joel C. Heimann, Eder C.R. Quintão

“…Experiments were carried out on LDL receptor (LDLR) knockout (KO) mice, or apolipoprotein E (apoE) KO mice on a low sodium chloride diet (LSD) as compared with a normal salt diet (NSD). …”
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Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo by P C Rensen, N Herijgers, M H Netscher, S C Meskers, M van Eck, T J van Berkel

“…Apolipoprotein E (apoE) is an important determinant for the uptake of triglyceride-rich emulsions and lipoproteins by the liver, and exerts affinity for both the LDL receptor (LDLr) and a distinct liver-specific recognition site. …”
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OptiMo‐LDLr: An Integrated In Silico Model with Enhanced Predictive Power for LDL Receptor Variants, Unraveling Hot Spot Pathogenic Residues by Asier Larrea‐Sebal, Iñaki Sasiain, Shifa Jebari‐Benslaiman, Unai Galicia‐Garcia, Kepa B. Uribe, Asier Benito‐Vicente, Irene Gracia‐Rubio, Harbil Bediaga‐Bañeres, Sonia Arrasate, Ana Cenarro, Fernando Civeira, Humberto González‐Díaz, Cesar Martín

“…Abstract Familial hypercholesterolemia (FH) is an inherited metabolic disease affecting cholesterol metabolism, with 90% of cases caused by mutations in the LDL receptor gene (LDLR), primarily missense mutations. …”
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VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100 by Henryk Zulewski, Ron Ninnis, André R. Miserez, Manfred W. Baumstark, Ulrich Keller

“…Mutations in the apolipoprotein (apo) B, E (LDL) receptor gene and in the apolipoprotein B-100 gene are the cause of familial hypercholesterolemia (FH) and of familial defective apo B-100 (FDB), respectively. …”
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Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages by Tircol Magdalena, Tirziu Daniela, Simionescu Maya

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Transcriptional and post-transcriptional regulation of LDL receptor gene expression in PMA-treated THP-1 cells by LDL-containing immune complexes. by Y Huang, M J Ghosh, M F Lopes-Virella

“…We have previously shown that uptake of low density lipoprotein-containing immune complexes (LDL-IC) by human monocyte-derived macrophages led to the transformation of these cells into foam cells and induced a paradoxical increase in receptor-mediated binding of 125I-labeled LDL due to an increase in the number of LDL receptors (LDL-R). The same metabolic changes are also observed in PMA-treated THP-1 cells after incubation for 2 h with 150 microg/ml of immune complexes containing either native, oxidized (ox), or malondialdehyde (mda) LDL. …”
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D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet by Georgette M. Buga, Joy S. Frank, Giuliano A. Mottino, Michael Hendizadeh, Ashkan Hakhamian, Jan H. Tillisch, Srinivasa T. Reddy, Mohamad Navab, G.M. Anantharamaiah, Louis J. Ignarro, Alan M. Fogelman

“…LDL receptor-null mice on a Western diet (WD) have inflammation in large arteries and endothelial dysfunction in small arteries, which are improved with the apolipoprotein A-I mimetic D-4F. …”
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LDL-receptor gene polymorphism as a predictor of coronary artery disease: an Egyptian pilot study: relation to lipid profile and angiographic findings by Kefaya El-Sayed, Amany R. Youssef, Nehal M. Abdel Hay, Adel M. Osman

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Synergic effect of Eicosapentaenoic acid and Lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells by Miccolis Angelica, Tutino Valeria, Refolo Maria G, Messa Caterina, Notarnicola Maria, Caruso Maria G

“…The purpose of this study was to investigate whether combined treatment with Eicosapentaenoic acid (EPA) and lovastatin enhanced the regulatory effect on gene expression of HMGCoA reductase and LDL receptor in HepG2 cell line.</p> <p>Results</p> <p>The combined treatment with EPA and lovastatin enhanced the regulatory effect on gene expression of HMGCoA reductase and LDL receptor in HepG2 cell line. …”
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Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice. by Florian Willecke, Chujun Yuan, Kazuhiro Oka, Lawrence Chan, Yunying Hu, Shelley Barnhart, Karin E Bornfeldt, Ira J Goldberg, Edward A Fisher

“…We tested whether a high fat diet (HFD) containing the inflammatory dietary fatty acid palmitate or insulin deficient diabetes altered the remodeling of atherosclerotic plaques in LDL receptor knockout (Ldlr-/-) mice. Cholesterol reduction was achieved by using a helper-dependent adenovirus (HDAd) carrying the gene for the low-density lipoprotein receptor (Ldlr; HDAd-LDLR). …”
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Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet by Igor Cândido Viana Gonçalves, Cláudio Daniel Cerdeira, Eduardo Poletti Camara, José Antônio Dias Garcia, Maísa Ribeiro Pereira Lima Brigagão, Roberta Bessa Veloso Silva, Gérsika Bitencourt dos Santos

“…This study investigated the effects of the nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol) on lipid profile and cardiac morphology in low-density lipoprotein (LDL) receptor gene knockout (LDLr-/-) mice. Methods: Male LDLr-/- mice (three months old, approximately 22 g weight) were divided into the following groups: controls, including (1) standard chow (SC, n=8) and (2) high-fat diet (HFD, n=8); and treatment, including (3) standard chow + Tempol (SC+T, n=8) (30 mg/kg administered by gavage, once daily) and (4) high-fat diet + Tempol (HFD+T, n=8) (30 mg/kg). …”
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Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice by Bosch Fatima, Kholová Ivana, Loponen Elina, Mäkinen Petri I, Hedman Marja, Merentie Mari, Heinonen Suvi E, Laakso Markku, Ylä-Herttuala Seppo

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PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice by Laura M. de Jong, Zhengzheng Zhang, Yvette den Hartog, Timothy J. P. Sijsenaar, Renata Martins Cardoso, Martijn L. Manson, Thomas Hankemeier, Peter W. Lindenburg, Daniela C. F. Salvatori, Miranda Van Eck, Menno Hoekstra

“…In conclusion, we have shown that SGC707 treatment reduces hepatic steatosis and plasma triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice. These findings suggest that pharmacological PRMT3 inhibition can serve as therapeutic approach to treat non-alcoholic fatty liver disease and dyslipidemia/atherosclerosis, when unwanted effects on cholesterol and bile acid metabolism can be effectively tackled.…”
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Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor by Stephanie D. Burr, Yongbin Chen, Christopher P. Hartley, Xianda Zhao, Jun Liu

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Characterization of mutations in the low density lipoprotein (LDL)-receptor gene in patients with homozygous familial hypercholesterolemia, and frequency of these mutations in FH patients in the United Kingdom by J C Webb, X M Sun, S N McCarthy, C Neuwirth, G R Thompson, B L Knight, A K Soutar

“…Mutations in the gene for the low density lipoprotein (LDL) receptor have been identified in 15 patients with homozygous familial hypercholesterolemia (FH). …”
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Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice. by Sofia Xanthoulea, Melanie Thelen, Chantal Pöttgens, Marion J J Gijbels, Esther Lutgens, Menno P J de Winther

“…METHODOLOGY/PRINCIPAL FINDINGS: p55 TNFR deficient mice were crossed to an LDL receptor deficient background and were induced for the development of either atherosclerosis or AngII-induced AAA, and compared to littermate controls, wild-type for p55 TNFR expression. p55 TNFR deficient mice developed 43% smaller atherosclerotic lesions in the aortic sinuses compared to controls. …”
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