ELISA measurement of LDL receptors by K May, FB Kraemer, J Chen, AD Cooper

“…An enzyme-linked immunosorbent assay was developed for measurement of low density lipoprotein (LDL) receptors. A monospecific polyclonal antibody to LDL receptor purified from rat liver that reacted with rat, mouse, canine, and human LDL receptor was used. …”
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Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice by Masa-aki Kawashiri, Yuzhen Zhang, David Usher, Muredach Reilly, Ellen Puré, Daniel J. Rader

“…Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice.…”
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Cellular uptake of lipoprotein[a] by mouse embryonic fibroblasts via the LDL receptor and the LDL receptor-related protein by T Reblin, A Niemeier, N Meyer, T E Willnow, F Kronenberg, H Dieplinger, H Greten, U Beisiegel

“…In conclusion, our results suggest that Lp[a] is a poor ligand for the LDL receptor and the LRP. The data of the displacement studies, however, indicated that the nonspecific uptake of Lp[a] constitutes a major route for the cellular Lp[a] catabolism in this study.…”
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Molecular characterization of the first avian LDL receptor by Susanna Hummel, Edward G. Lynn, Andreas Osanger, Satoshi Hirayama, Johannes Nimpf, Wolfgang J. Schneider

“…Low levels of expression and sluggish sterol-mediated regulation have been likely reasons for the failure to molecularly characterize a bona fide LDL receptor (LDLR) in egg-laying species to date. The overall structure of the chicken LDLR, delineated here by cDNA cloning, has been conserved in evolution, since hallmark properties of mammalian LDLRs are already present in the avian protein. …”
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PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment by Kristian Tveten, Thea Bismo Str⊘m, Knut Erik Berge, Trond P. Leren

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the LDL receptor (LDLR) at the cell surface and reroutes the internalized LDLR to intracellular degradation. …”
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S-nitrosylation of ARH is required for LDL uptake by the LDL receptor by Zhenze Zhao, Shanica Pompey, Hongyun Dong, Jian Weng, Rita Garuti, Peter Michaely

“…The LDL receptor (LDLR) relies upon endocytic adaptor proteins for internalization of lipoproteins. …”
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Primary structure comparison of the proposed low density lipoprotein (LDL) receptor binding domain of human and pig apolipoprotein B: implications for LDL-receptor interactions by D L Ebert, N Maeda, S W Lowe, J Hasler-Rapacz, J Rapacz, A D Attie

“…Apolipoprotein B (apoB) is the predominant protein in low density lipoprotein (LDL) and is responsible for LDL binding to the LDL receptor. Although the primary amino acid sequence of human apoB has been determined, little is known about the structural domains involved in mediating apoB binding to the LDL receptor. …”
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Effect of type 2 diabetes on the inducible degrader of LDL receptor by Sum Lam, David Tak Wai Lui, Sammy Wing Ming Shiu, Ying Wong, Kathryn Choon Beng Tan

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Modulation of the LDL receptor and LRP levels by HIV protease inhibitors by Huan Tran, Susan Robinson, Irina Mikhailenko, Dudley K. Strickland

“…We hypothesized that HIV protease inhibitors may affect gene regulation of certain LDL receptor (LDLR) family members, thereby altering the catabolism of cholesterol-containing lipoproteins. …”
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Heparan sulfate proteoglycans present PCSK9 to the LDL receptor by Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup

“…PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. …”
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Sex differences in the LDL receptor knockout mouse model of atherosclerosis by Neel A. Mansukhani, Zheng Wang, Vera P. Shively, Megan E. Kelly, Janet M. Vercammen, Melina R. Kibbe

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Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer by L.A. Pires, R. Hegg, F.R. Freitas, E.R. Tavares, C.P. Almeida, E.C. Baracat, R.C. Maranhão

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Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer by L.A. Pires, R. Hegg, F.R. Freitas, E.R. Tavares, C.P. Almeida, E.C. Baracat, R.C. Maranhão

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Novel mechanism of transcriptional activation of hepatic LDL receptor by oncostatin M by J Liu, R Streiff, Y L Zhang, R E Vestal, M J Spence, M R Briggs

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Neoagarooligosaccharides enhance the level and efficiency of LDL receptor and improve cholesterol homeostasis by Ji Hye Yang, Sam Seok Cho, Kyu Min Kim, Ji Young Kim, Eun Joo Kim, Eun Young Park, Je Hyeon Lee, Sung Hwan Ki

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Structural features of synthetic peptides of apolipoprotein E that bind the LDL receptor by C A Dyer, D P Cistola, G C Parry, L K Curtiss

“…Previously, we reported that a synthetic peptide representing a linear tandem repeat of amino acids 141-155, the 141-155 dimer, binds the low density lipoprotein (LDL) receptor. To define the structural features essential for LDL receptor binding of the 141-155 dimer, a series of modified peptides were synthesized. …”
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Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor by Danijela Lucic, Zhi Hua Huang, De Sheng Gu, Michael K. Altenburg, Nobuyo Maeda, Theodore Mazzone

“…Cells with increased LDL receptor expression also showed reduced apoE secretion compared with MPMs with basal LDL receptor expression. …”
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ANKLE-BRACHIAL INDEX AND LDL-RECEPTOR GENE IN ASYMPTOMATIC SEVERE HYPERCHOLESTEROLEMIA by L. Vladimirova-Kitova

“…The issue with the different levels of ankle-brachial index, as screening for LDL-receptor defective gene in newly detected asymptomatic severe hypercholesterolemia is less studied, but quite interesting. …”
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Structural basis for the recognition of LDL-receptor family members by VSV glycoprotein by Jovan Nikolic, Laura Belot, Hélène Raux, Pierre Legrand, Yves Gaudin, Aurélie A. Albertini

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Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase by Margaret E. Brousseau, Jian Wang, Stephen J. Demosky, Jr., Boris L. Vaisman, Glenda D. Talley, Silvia Santamarina-Fojo, H. Bryan Brewer, Jr., Jeffrey M. Hoeg

“…Correction of hypoalphalipoproteinemia in LDL receptor-deficient rabbits by lecithin:cholesterol acyltransferase.…”
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