In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements by Abigail F. Groff, Diana B. Sanchez-Gomez, Marcela M.L. Soruco, Chiara Gerhardinger, A. Rasim Barutcu, Eric Li, Lara Elcavage, Olivia Plana, Lluvia V. Sanchez, James C. Lee, Martin Sauvageau, John L. Rinn

“…The Linc-p21 locus, encoding a long non-coding RNA, plays an important role in p53 signaling, cell-cycle regulation, and tumor suppression. …”
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Changes in Nuclear Shape and Gene Expression in Response to Simulated Microgravity Are LINC Complex-Dependent by Srujana Neelam, Brian Richardson, Richard Barker, Ceasar Udave, Simon Gilroy, Mark J. Cameron, Howard G. Levine, Ye Zhang

Subjects: “…LINC complex…”
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Deciphering Estrus Expression in Gilts: The Role of Alternative Polyadenylation and LincRNAs in Reproductive Transcriptomics by Mingzheng Liu, Jiahao Chen, Chunlei Zhang, Shuhan Liu, Xiaohuan Chao, Huan Yang, Asim Muhammad, Bo Zhou, Weiping Ao, Allan P. Schinckel

“…Furthermore, 27 and 21 differentially expressed lincRNAs (DEL), whose target genes were enriched in the “Endocrine resistance” pathway, were identified in the vulva and vagina, respectively. …”
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Molecular interplay between linc01134 and YY1 dictates hepatocellular carcinoma progression by Zhonghou Rong, Zhiyi Wang, Xinxing Wang, Chengkun Qin, Wenmao Geng

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A deep learning method for lincRNA detection using auto-encoder algorithm by Ning Yu, Zeng Yu, Yi Pan

Subjects: “…Long intergenic non-coding RNA (lincRNA)…”
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LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription by Bingqiu Xiu, Yayun Chi, Lei Liu, Weiru Chi, Qi Zhang, Jiajian Chen, Rong Guo, Jing Si, Lun Li, Jingyan Xue, Zhi-Ming Shao, Zhao-Hui Wu, Shenglin Huang, Jiong Wu

Subjects: “…LINC02273…”
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L1000 Viewer: A Search Engine and Web Interface for the LINCS Data Repository by Aliyu Musa, Aliyu Musa, Shailesh Tripathi, Shailesh Tripathi, Matthias Dehmer, Matthias Dehmer, Matthias Dehmer, Frank Emmert-Streib, Frank Emmert-Streib

“…The LINCS L1000 data repository contains almost two million gene expression profiles for thousands of small molecules and drugs. …”
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Silencing of LINC00467 inhibits cell proliferation in testicular germ cell tumors cells by Fang Zhu, Zhizhong Liu, Qianyin Zhou, Dai Zhou, Jingyu Fan, Hao Bo, Liqing Fan

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Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy by Chih-Chun Chuang, Chih-Chun Chuang, Yi-Sun Yang, Yi-Sun Yang, Edy Kornelius, Edy Kornelius, Chien-Ning Huang, Chien-Ning Huang, Chien-Ning Huang, Min-Yen Hsu, Min-Yen Hsu, Chia-Yi Lee, Shun-Fa Yang, Shun-Fa Yang

“…Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT + TT variant than that in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, p = 0.009). …”
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LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining by Lawrence, Katherine S., Tapley, Erin C., Cruz, Victor E., Li, Qianyan, Aung, Kayla, Hart, Kevin C., Starr, Daniel A., Engebrecht, JoAnne, Schwartz, Thomas

“…Furthermore, the microtubule network and interaction with the nucleoskeleton are important for repair, suggesting that a functional linker of nucleoskeleton and cytoskeleton (LINC) complex is required. We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks.…”
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Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution by Ulitsky, Igor, Shkumatava, Alena, Jan, Calvin H., Sive, Hazel L., Bartel, David, Jan, Calvin H.

“…Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data to identify more than 550 distinct lincRNAs in zebrafish. …”
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Multiple knockout mouse models reveal lincRNAs are required for life and brain development by Goff, Loyal, Kellis, Manolis, Sauvageau, Martin, Lodato, Simona, Bonev, Boyan, Groff, Abigail F., Gerhardinger, Chiara, Sanchez-Gomez, Diana B., Hacisuleyman, Ezgi, Li, Eric, Spence, Matthew, Liapis, Stephen C., Mallard, William, Morse, Michael, Swerdel, Mavis R., D'Ecclessis, Michael F., Moore, Jennifer C., Lai, Venus, Gong, Guochun, Yancopoulos, George D., Frendewey, David, Hart, Ronald P., Valenzuela, David M., Arlotta, Paola, Rinn, John L.

“…We also report growth defects for two additional mutant strains (linc–Brn1b and linc–Pint). Further analysis revealed defects in lung, gastrointestinal tract, and heart in Fendrr[superscript −/−] neonates, whereas linc–Brn1b[superscript −/−] mutants displayed distinct abnormalities in the generation of upper layer II–IV neurons in the neocortex. …”
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Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome. by Young, R, Marques, A, Tibbit, C, Haerty, W, Bassett, A, Liu, J, Ponting, C

“…The functional repertoire of long intergenic noncoding RNA (lincRNA) molecules has begun to be elucidated in mammals. …”

A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction. by Junwei Pan, Ming Liu, Xiaozong Duan, Dan Wang

“…The effect of the short peptide on protein interactions were confirmed by Co-Immunoprecipitation (CoIP) assays. We found that lncRNA LINC00665 encoded an 18-amino acid (aa)-long short peptide (named LINC00665_18aa). …”
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Comprehensive Analysis of CDK1-Associated ceRNA Network Revealing the Key Pathways LINC00460/LINC00525-Hsa-Mir-338-FAM111/ZWINT as Prognostic Biomarkers in Lung Adenocarcinoma Combined with Experiments by Wen Li, Shan-Shan Feng, Hao Wu, Jing Deng, Wang-Yan Zhou, Ming-Xi Jia, Yi Shi, Liang Ma, Xiao-Xi Zeng, Zavuga Zuberi, Da Fu, Xiang Liu, Zhu Chen

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Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs by Wan-Hsin Liu, Zing Tsung-Yeh Tsai, Huai-Kuang Tsai

“…Abstract Background The regulatory roles of long intergenic noncoding RNAs (lincRNAs) in humans have been revealed through the use of advanced sequencing technology. …”
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The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal by Miki Hieda, Taizo Matsumoto, Mari Isobe, Sadamu Kurono, Kaneko Yuka, Satoshi Kametaka, Jing-Ya Wang, Ya-Hui Chi, Kenji Kameda, Hiroshi Kimura, Nariaki Matsuura, Shuji Matsuura

“…These findings revealed a regulation of the Golgi organization by the LINC complex.…”
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Comprehensive analysis of ceRNA network related to lincRNA in glioblastoma and prediction of clinical prognosis by Guangdong Liu, Danian Liu, Jingjing Huang, Jianxin Li, Chuang Wang, Guangyao Liu, Shiqiang Ge, Haidong Gong

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JPX and LINC00641 ncRNAs expression in prostate tissue: a case-control study by Roshanak S Sajjadi, Mohammad Hossein Modarressi, Mohammad Amin Tabatabaiefar

Subjects: “…gene expression; jpx; linc00641; long non-coding rna; prostate cancer.…”
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Clinical Significance Of Linc00342 Expression In The Peripheral Blood Lymphocytes Of Patients With Chronic Kidney Disease by Liu C, Xu Y, Wu X, Zou Q

Subjects: “…linc00342…”
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