Evolutionary Evidence of Algal Polysaccharide Degradation Acquisition by Pseudoalteromonas carrageenovora 9T to Adapt to Macroalgal Niches by Angélique Gobet, Tristan Barbeyron, Maria Matard-Mann, Maria Matard-Mann, Ghislaine Magdelenat, David Vallenet, Eric Duchaud, Gurvan Michel

“…Whereas P. carrageenovora is able to use lambda-carrageenan as a sole carbon source, genomic and physiological analyses demonstrate that its catabolic pathway for kappa- and iota-carrageenan is incomplete. …”
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B cell receptor repertoire analysis in primary Sjogren’s syndrome salivary glands identifies repertoire features associated with clinical activity by Ling Chang, Zihan Zheng, Yiwen Zhou, Kun Liu, Yinong Li, Bing Zhong, Zihua Zhao, Chengshun Chen, Can Qian, Qingshan Ni, Qinghua Zou, Yuzhang Wu, Jingyi Li, Liyun Zou

“…We further observe significant decreases in IgA2 isotype usage among pSS patient labial and parotid gland B cells these analyses relative to controls as well as a positive correlation between kappa/lambda light chain usage and clinical disease activity. …”
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Novel Epitope Mapping of African Swine Fever Virus pI215L Protein Using Monoclonal Antibodies by Yanni Gao, Xiaolin Jiang, Xing Yang, Keshan Zhang, Ping Jiang, Juan Bai

“…Among them, 1C4, 5E1, and 5B3 had the IgG1 isotype with a Lambda light chain, 2F10 and 3C8 had the IgG1 isotype with a Kappa light chain, and 2F6 had the IgG2a isotype with a Kappa light chain. …”
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Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries by Andre Azevedo Reis Teixeira, Michael Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker, Andrew Raymon Morton Bradbury

“…We anticipate that the designs and approaches presented here will accelerate the drug development process by reducing the failure rate of leads due to poor antibody affinities and developability.Abbreviations: AC-SINS: affinity-capture self-interaction nanoparticle spectroscopy; CDR: complementarity-determining region; CQA: critical quality attribute; ELISA: enzyme-linked immunoassay; FACS: fluorescence-activated cell sorting; Fv: fragment variable; GM-CSF: granulocyte-macrophage colony-stimulating factor; HCDR3: heavy chain CDR3; IFN2a: interferon α-2; IL6: interleukin-6; MACS: magnetic-activated cell sorting; NGS: next generation sequencing; PCR: polymerase chain reaction; SEC: size-exclusion chromatography; SPR: surface plasmon resonance; TGFβ-R2: transforming growth factor β-R2; VH: variable heavy; VK: variable kappa; VL: variable light; Vl: variable lambda;…”
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Transfer of Viral Communities between Human Individuals during Fecal Microbiota Transplantation by Christel Chehoud, Anatoly Dryga, Young Hwang, Dorottya Nagy-Szakal, Emily B. Hollister, Ruth Ann Luna, James Versalovic, Richard Kellermayer, Frederic D. Bushman

“…In addition, members of Siphoviridae, the group of typically temperate phages that includes phage lambda, were found to be transferred with significantly greater efficiency than other groups. …”
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Scale setting and the light baryon spectrum in N f = 2 + 1 QCD with Wilson fermions by The RQCD collaboration, Gunnar S. Bali, Sara Collins, Peter Georg, Daniel Jenkins, Piotr Korcyl, Andreas Schäfer, Enno E. Scholz, Jakob Simeth, Wolfgang Söldner, Simon Weishäupl

“…Moreover, we determine SU(3) and SU(2) chiral perturbation theory low energy constants, including the octet and the Ω baryon sigma terms σ πN = 43.9(4.7) MeV, σ π Λ = 28.2 5.4 4.3 $$ {\sigma}_{\pi \Lambda}={28.2}_{(5.4)}^{(4.3)} $$ MeV, σ π Σ = 25.9 6.1 3.8 $$ {\sigma}_{\pi \Sigma}={25.9}_{(6.1)}^{(3.8)} $$ MeV, σ π Ξ = 11.2 6.4 4.5 $$ {\sigma}_{\pi \Xi}={11.2}_{(6.4)}^{(4.5)} $$ and σ π Ω = 6.9 4.3 5.3 $$ {\sigma}_{\pi \Omega}={6.9}_{(4.3)}^{(5.3)} $$ MeV, as well as various parameters, renormalization factors and improvement coefficients that are relevant for simulations with our lattice action.…”
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Can the adverse childhood experiences (ACEs) checklist be utilized to predict emergency department visits among children and adolescents? by Asmita Bhattarai, Gina Dimitropoulos, Brian Marriott, Jaime Paget, Andrew G. M. Bulloch, Suzanne C. Tough, Scott B. Patten

“…Two Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression models, each employing a different method to tune the shrinkage parameter lambda (namely cross-validated and adaptive) and performing 10-fold cross-validation for a set of 100 lambdas in each model were examined. …”
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Risk of death, hospitalization and intensive care unit admission by SARS-CoV-2 variants in Peru: a retrospective study by Diego Fano-Sizgorich, Cinthya Vásquez-Velásquez, Laura R. Orellana, Christian Ponce-Torres, Henry Gamboa-Serpa, Keyla Alvarez-Huambachano, Gustavo F. Gonzales

“…Crude and adjusted Cox proportional hazards regressions with clustered variances were modeled to calculate the hazard ratio (HR) of outcomes by variant. Results: Lambda variant had the highest risk of death (HR 1.92, 95% CI 1.37-2.68), whereas the Delta variant had the lowest risk (HR 0.50, 95% CI 0.31-0.82). …”
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Safety, Tolerability, and Immunogenicity of Interferons by Michael G. Tovey, Christophe Lallemand

“…Type II IFN, or IFN gamma, is used principally for the treatment of chronic granulomatous disease, while the recently discovered type III IFNs, also known as IFN lambda or IL-28/29, are currently being evaluated for the treatment of chronic viral hepatitis. …”
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The effect of root orientation on inferior alveolar nerve injury after extraction of impacted mandibular third molars based on propensity score-matched analysis: a retrospective co... by Shijun Kuang, Yuhao Liu, Weijie Zhuang, Kechen Li, Wenbin Yang, Yihong Tian

“…The correlation between third molar root orientation and impaction depth/contact degree with IAN was evaluated by the Lambda coefficient. Based on PSM for balancing confounding factors including age, sex, impaction depth, and contact degree, the effect of root orientation on the incidence of IAN injury was further analyzed using Fisher’s exact test. …”
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A Model for Predicting the Duration of Viral Shedding in Patients Who Had Been Hospitalized with Mild COVID-19: A Single-Center Retrospective Study by Zhang YD, He TW, Chen YR, Xiong BD, Zhe Z, Liu P, Tang BQ

“…Using LASSO with viral shedding time as the outcome variable, the model with lambda as 0.1592 (λ = 0.1592) and 13 variables (eg the time from diagnosis to admission, constipation, cough, hs-CRP, IL-8, IL-1β, etc.) was more accurate. …”
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ASFV pD345L protein negatively regulates NF-κB signalling by inhibiting IKK kinase activity by Huan Chen, Zhenzhong Wang, Xiaoyu Gao, Jiaxuan Lv, Yongxin Hu, Yong-Sam Jung, Shanyuan Zhu, Xiaodong Wu, Yingjuan Qian, Jianjun Dai

“…Here, we show that pD345L, an ASFV-encoded lambda-like exonuclease, acts as an inhibitor of cGAS/STING-mediated NF-κB signalling by blocking the IkappaB kinase (IKKα/β) activity. …”
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Development of Porcine Monoclonal Antibodies with In Vitro Neutralizing Activity against Classical Swine Fever Virus from C-Strain E2-Specific Single B Cells by Lihua Wang, Rachel Madera, Yuzhen Li, Douglas P. Gladue, Manuel V. Borca, Michael T. McIntosh, Jishu Shi

“…Overall, we obtained 3 IgG H chains, 9 kappa L chains and 36 lambda L chains, which include three paired chains (two H + κ and one H + λ). …”
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THE SPECIFICITY OF THE OVARIAN RESERVE OF WOMEN WITH CHRONIC SALPINGOOPHORITIS by V. A. Novikova, F. R. Autleva, A. A. Sorochenko, D. I. Fayzullina, E. V. Nurgalieva

“…Based on the discriminant analysis, it was found that the main indicators determining the specificity of the OR in ChrSO, depending on the phase of reproductive age, are the number of antral follicles, estradiol level and AMH (Wilks’ lambda = 0.35503, p<0.0001). The specificity of the OR of women with ChrSO (difference from the control group), regardless of the phase of reproductive age, initially and when evaluated after 6 months, is determined by the number of AF and the level of estradiol and AMH; the number of AF and AMH is determined with a similar estimate after 12 months. …”
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Βιβλιοκρισία: Neglected Barbarians, επιμ. εκδ. F. CURTA [Studies in the Early Middle Ages 32], Brepols Publishers n.v., Turnhout 2010. 629 σ., 24 έγχρωμες εικόνες, ISBN: 978-2-503-... by Γεώργιος ΚΑΡΔΑΡΑΣ

“…<p style="text-align: justify; line-height: 150%; margin-right: 49.25pt" class="MsoNormal"><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt">&Beta;</span><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt">&iota;&beta;&lambda;&iota;&omicron;&kappa;&rho;&iota;&sigma;ί&alpha;:</span><em><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt"> Neglected</span></em><em><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt"> </span></em><em><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt">Barbarians</span></em><span style="line-height: 150%; font-family: 'Palatino Linotype','serif'; font-size: 10pt">, &epsilon;&pi;&iota;&mu;. …”
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IFNL3 rs12980275 Polymorphism Predicts Septic Shock-Related Death in Patients Undergoing Major Surgery: A Retrospective Study by Felipe Pérez-García, Maria Ángeles Jiménez-Sousa, Susana Soria, Pablo Jorge-Monjas, Amanda Fernández-Rodríguez, Esther Gómez-Sánchez, María Heredia-Rodríguez, Estefanía Gómez-Pesquera, Pedro Martínez-Paz, Eduardo Tamayo, Salvador Resino

“…Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. …”
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Tracking SARS-CoV-2 Variants Using a Rapid Typification Strategy: A Key Tool for Early Detection and Spread Investigation of Omicron in Argentina by Gonzalo M. Castro, Paola Sicilia, María Laura Bolzon, Laura Lopez, María Gabriela Barbás, María Belén Pisano, Viviana E. Ré

“…Since VOC Delta entered into the region, it increased gradually, together with VOI Lambda, replacing VOC Gamma, until being the main variant (84.9%) on November. …”
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Ring-Core Photonic Quasi-Crystal Fiber With 34 Polarization Multiplexing Modes by Wei Wei, Yitong Wang, Hongyang Zhao, Ziming Dong, Liqin Tang, Lei Ding, Yigang Li

“…The dispersion (<inline-formula><tex-math notation="LaTeX">${D_\lambda }$</tex-math></inline-formula>) of FV-PMs is less than <inline-formula><tex-math notation="LaTeX">$138.14{\mathrm{\ ps}} \cdot {\mathrm{n}}{{\mathrm{m}}^{ - 1}} \cdot {\mathrm{k}}{{\mathrm{m}}^{ - 1}}$</tex-math></inline-formula> and maintains a flat trend. …”
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Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients by Maria Clara Saad Menezes, Alicia Dudy Müller Veiga, Thais Martins de Lima, Suely Kunimi Kubo Ariga, Hermes Vieira Barbeiro, Claudia de Lucena Moreira, Agnes Araujo Sardinha Pinto, Rodrigo Antonio Brandao, Julio Flavio Marchini, Julio Cesar Alencar, Lucas Oliveira Marino, Luz Marina Gomez, Niels Olsen Saraiva Camara, Heraldo P. Souza

“…In the peripheral blood, gene expression (mRNA) of Toll-like receptors (TLRs) 3, 4, 7, 8, and 9, retinoic-acid inducible gene I (RIGI), NOD-like receptor family pyrin domain containing 3 (NLRP3), interferon alpha (IFN-α), interferon beta (IFN-β), interferon gamma (IFN-γ), interferon lambda (IFN-λ), pro-interleukin(IL)-1β (pro-IL-1β), and IL-18 was determined on admission, between 5–9 days, and between 10–15 days. …”
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What is the benefit of ceilometers for aerosol remote sensing? An answer from EARLINET by M. Wiegner, F. Madonna, I. Binietoglou, R. Forkel, J. Gasteiger, A. Geiß, G. Pappalardo, K. Schäfer, W. Thomas

“…The latter is relevant for the very large number of ceilometers operating in the spectral range around &lambda; = 905–910 nm. The accuracy of the retrieved &beta;_p mainly depends on the accuracy of the calibration and the long-term stability of the ceilometer. …”
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