Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants by Ye-Fan Hu, Ye-Fan Hu, Jing-Chu Hu, Hua-Rui Gong, Antoine Danchin, Antoine Danchin, Ren Sun, Hin Chu, Ivan Fan-Ngai Hung, Kwok Yung Yuen, Kelvin Kai-Wang To, Bao-Zhong Zhang, Thomas Yau, Jian-Dong Huang, Jian-Dong Huang, Jian-Dong Huang

“…Our predicted results were comparable to experimental neutralization titers of variants, including Alpha, Beta, Delta, Gamma, Epsilon, Iota, Kappa, and Lambda, as well as SARS-CoV. Here, we predicted the fold of decrease of Omicron as 17.4-fold less susceptible to neutralization. …”
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CLASH-VLT: The Inner Slope of the MACS J1206.2-0847 Dark Matter Density Profile by Andrea Biviano, Lorenzo Pizzuti, Amata Mercurio, Barbara Sartoris, Piero Rosati, Stefano Ettori, Marisa Girardi, Claudio Grillo, Gabriel B. Caminha, Mario Nonino

“…We find ${\gamma }_{\mathrm{DM}}={0.7}_{-0.1}^{+0.2}$ (68% confidence levels), consistent with predictions from recent Lambda cold dark matter cosmological numerical simulations.…”
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Sliding Mode and PI-Based Control for the SISO “Full-Bridge Buck Inverter–DC Motor” System Powered by Renewable Energy by Rogelio Ernesto Garcia-Chavez, Angel Adrian Orta-Quintana, Ramon Silva-Ortigoza, Victor Manuel Hernandez-Guzman, Magdalena Marciano-Melchor, Jose Rafael Garcia-Sanchez, Gilberto Silva-Ortigoza, Hind Taud, Miguel Gabriel Villarreal-Cervantes

“…The performance of the developed control scheme is experimentally validated using the system prototype, the TDK-Lambda G100-17 renewable energy emulator source, the DS1104 board, and the Matlab-Simulink software. …”
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NEUROPATIA DESMIELINIZANTE SIMÉTRICA DISTAL RELACIONADA A GAMOPATIA MONOCLONAL IGM (DADS-M): RELATO DE CASO by MT Dias, LB Ribeiro, IC Lima, GTC Mayrink, AA Ferreira

“…Investigação adicional com imunofixação sérica identificou padrão IgM/Lambda. Biópsia de medula óssea e mielograma excluíram Mieloma Múltiplo. …”
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Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients by Kun Wang, Kun Wang, Haomin Li, Junyu Zhao, Jinming Yao, Yiran Lu, Jianjun Dong, Jie Bai, Lin Liao, Lin Liao

“…For the prognostic model, the riskscore = (-0.0058)*CD82+(-0.4994)*+(0.1584)*TSPAN11+(1.7597)*TSPAN19+(0.2694)*TSPAN2 (lambda.min = 0.0149). The AUCs for 3-year, 5-year, and 10-year OS were 0.81, 0.851, and 0.804. …”
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Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease by François Lestelle, Catherine Beigelman, David Rotzinger, Salim Si-Mohamed, Mouhamad Nasser, Lidwine Wemeau, Sandrine Hirschi, Grégoire Prevot, Antoine Roux, Vincent Bunel, Emmanuel Gomez, Laurent Sohier, Helene Morisse Pradier, Martine Reynaud Gaubert, Anne Gondouin, Romain Lazor, Jean-Charles Glerant, Françoise Thivolet Bejui, Magali Colombat, Vincent Cottin, the OrphaLung network

“…Histological analysis showed kappa light chain deposits in all patients, except one with lambda chain deposits. Median annual FEV1 decline was 127 ml (IQR 178) and median DLCO decline was 4.3% (IQR 4.3). …”
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An Immunohistological Study of Human and Murine Lymphomata. by Taylor, C

“…In some cases the pattern of immunoglobulin staining was clearly monoclonal (exclusively kappa chain or exclusively lambda chain within the neoplastic population) but in others both kappa and lambda chain were apparently present in the same cell. …”

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity by Fuhua Wu, Shuang Luo, Yongshun Zhang, Yangsen Ou, Hairui Wang, Zhaofei Guo, Chunting He, Shuting Bai, Penghui He, Min Jiang, Xiaoyan Chen, Guangsheng Du, Xun Sun

“…Compared to the licensed BBIBP-CorV (Sinopharm, China), a single-dose S663V-RBD induced more endurable and robust immune responses in mice and elicited superior neutralizing antibodies against three typical SARS-CoV-2 pseudoviruses including wild type, C.37 (Lambda) and B.1.617.2 (Delta). More interestingly, the intramuscular injection of S663V-RBD could overcome pre-existing immunity against the capsid. …”
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ESTUDO RETROSPECTIVO DE LEUCEMIAS AGUDAS POR CITOMETRIA DE FLUXO by IAF Bahia, GHM Oliveira, O Cabra-Marques, AD Luchessi, APR Neta, RD Lima, FCM Theodoro, RE Martins, TMM Oliveira, GBC Junior

“…As LLA-B foram analisadas com base na intensidade de expressão ou ausência de marcadores, em LLA-pro-B, ou linfoma leucemizado, (CD19, HLA-Dr, CD34 e TdT), LLA-comum (CD10, CD19, cCD79a, cCD22, HLA-Dr, TdT e CD34), LLA pré-B (cIgM, CD19, HLA-Dr, cCD79a, cCD22 e CD10) e LLA-B-Madura (sIgM+, sCD22, CD10+/-, CD20 e kappa ou lambda). As LLA-T foram analisadas no mesmo formato e subdivididas em pré-LLAT (CD7, cCD3, HLA-Dr, CD34 e TdT), LLA-T intermediárias (CD1a, CD2, CD7, cCD3, TdT e HLA-Dr associadas a CD4+/CD8+) e LLA-T medulares (CD4 ou CD8, sCD3, CD1a, TdT, HLA-Dr e CD34). …”
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REVISÃO DA ABORDAGEM DO CD38 MULTIEPÍTOPO NA DETECÇÃO DE DRM APÓS TERAPIA COM DARATUMUMABE EM MIELOMA MÚLTIPLO by TT Takao, YH Maekawa, ACT Siva, RG Silva, DC Daniel, MC Bruno, JG Rodrigues, MV Gonçalves, MCA Silva, AF Sandes

“…Esse kit inclui antígenos como CD38 multiepítopo, CD138, e outros, além de Ig Kappa e Ig Lambda intracitoplasmáticos. Os PCs são identificados por expressões fortes de CD38 e CD138, expressão monotípica da cadeia leve e fenótipos aberrantes. …”
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HIPERTENSÃO PULMONAR GRAVE REVERSÍVEL COM TRATAMENTO ANTI PLASMOCITÁRIO EM MIELOMA MÚLTIPLO INDOLENTE: RELATO DE CASO by AFV Agreda, JVR Oliveira, MAC Sartori, RBE Nogueira, LDV Grassi, IS Macêdo, MA Pinto, EA Junior, V Rocha, GA Martinez

“…Prosseguiu-se com investigação de doença plasmocitária: imunofixação IgG/kappa, relação Kappa/Lambda livres:10,1. Avaliação medular: celularidade aumentada e presença de 17,2% de plasmócitos, imunofenotipagem: com clonalidade kappa, e ausência de lesões de órgão alvo para mieloma, compatível com diagnóstico de MMI. …”
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A Shared Aperture X/Ku-Band 5-Group- 5-Element Series-Fed Center-Fed Antenna Array With Isolation Improvement for Airborne Synthetic Aperture Radar Applications by Praveena Kati, Venkata Kishore Kothapudi

“…The inter-element spacing between patches is set at <inline-formula> <tex-math notation="LaTeX">$0.7\lambda $ </tex-math></inline-formula> to meet the <inline-formula> <tex-math notation="LaTeX">$\pm 25^{0}$ </tex-math></inline-formula> scan range requirements. …”
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Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators by Vasiliki Lagou, Josselyn E. Garcia-Perez, Ide Smets, Lies Van Horebeek, Marijne Vandebergh, Liye Chen, Klara Mallants, Teresa Prezzemolo, Kelly Hilven, Stephanie Humblet-Baron, Matthieu Moisse, Philip Van Damme, Guy Boeckxstaens, Paul Bowness, Bénédicte Dubois, James Dooley, Adrian Liston, An Goris

“…Genetic variation controlling disease-relevant T helper cell subsets includes RICTOR and STON2 associated with Th2 and Th17, respectively, and the interferon-lambda locus controlling regulatory T cell proliferation. …”
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NEOPLASIA MIELODISPLÁSICA (SMD) SECUNDÁRIA A LEUCEMIA LINFOCÍTICA CRÔNICA (LLC) by ML Puls, TFN Araujo, BA Souza, CF Morais, PHA Moraes, RS Szor, CD Liz, ACA Maia, VC Molla, CAR Silva

“…Na época, apresentava linfocitose superior a 5.000 mm3 em sangue periférico com imunofenotipagem sugestiva de LLC (CD19, CD5, CD45 e lâmbda positivos; CD20 fracamente positivo; negativo para CD23, CD38, FMC7). …”
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SARS-CoV-2 Variants in Paraguay: Detection and Surveillance with an Economical and Scalable Molecular Protocol by Magaly Martinez, Phuong-Vi Nguyen, Maxwell Su, Fátima Cardozo, Adriana Valenzuela, Laura Franco, María Eugenia Galeano, Leticia Elizabeth Rojas, Chyntia Carolina Díaz Acosta, Jonás Fernández, Joel Ortiz, Florencia del Puerto, Laura Mendoza, Eva Nara, Alejandra Rojas, Jesse J. Waggoner

“…Samples were positive for the SARS-CoV-2 N2 target and tested with the Spike SNP assay to detect mutations associated with the following variants: alpha (501Y), beta/gamma (417variant/484K/501Y), delta (452R/478K), and lambda (452Q/490S). Spike SNP calls were confirmed using amplicon (Sanger) sequencing and whole-genome (Nanopore) sequencing on a subset of samples with confirmed variant lineages. …”
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LINFOMA PLASMABLÁSTICO SEM INFECÇÃO POR HIV - RELATO DE CASO by MG Cliquet, G Lazzari, LS Goes, JA Rena, DR Spada, BN Nascimento, GM Pascoal

“…O perfil imunofenotípico da LPB apresenta positividade para CD79a, IRF-4/MUM-1, BLIMP-1, CD38 e CD138 além de restrição de cadeia leve de imunoglobulinas citoplasmáticas (kappa ou lambda). Ainda, é negativo para os marcadores de células B CD19, CD20 e PAX-05, podendo ser fracamente positivo para CD45 e possui índice de proliferação K1-67 elevado. …”
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GAMOPATIA MONOCLONAL DE SIGNIFICADO RENAL: RELATO DE CASO by V Drumond, AA Ferreira, M Carminatti, F Sales, TS Cruz, BRC Brito, KMM Ribeiro, MFCB Valente, GTC Mayrink

“…A imunofixação de proteínas mostrou padrão oligoclonal IgG, kappa e lambda no soro e monoclonal IgG/kappa na urina. A biópsia de medula óssea não demonstrou infiltrado plasmocitário anormal e a pesquisa de amiloide foi negativa. …”
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SÍNDROME POEMS – DOENÇA LIMITADA by RS Melo, ACON Luz, FA Silva, LB Lanza, LV Cota, NCR Cunha, RL Pacca, SS Fernandes, PMM Garibaldi

“…Identificada lesão osteoesclerótica em osso ilíaco, que após biópsia, demonstrou infiltração por plasmócitos monoclonais lambda. Realizada complementação propedêutica concluindo o diagnóstico Síndrome POEMS. …”
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RELATO DE CASO: MIELOMA MÚLTIPLO EM PACIENTE COM LEUCEMIA MIELÓIDE CRÔNICA by ILA Silva, RDA Silva, LFDS Silva, PVMG Jatobá, SRA Pimentel, JPAS Netto, MFA Mota, MS Moura

“…Exames laboratoriais: Hb = 8,8 mg/dL, reticulócitos = 5.742 (1,8%), creatinina = 1,72, cálcio = 9,6, abumina = 2,7, DHL normal, eletroforese de proteínas séricas com pico monoclonal de 5,4 g, imunoeletroforese = IgG/lambda (IgG = 6.586 mg/dL) e beta2microglobulina = 9.340 ng/mL. …”
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SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells by Kai Yang, Shiyun Liu, Han Yan, Wenju Lu, Xiaoqian Shan, Haixia Chen, Changlei Bao, Huazhuo Feng, Jing Liao, Shuxin Liang, Lei Xu, Haiyang Tang, Jason X.-J. Yuan, Nanshan Zhong, Jian Wang

“…Transcriptomic analysis indicates that prototypic S-RBD confers more severe acute impacts than Delta or Lambda S-RBD. In summary, this study provides compelling evidence that S-RBD could induce persistent pulmonary vascular endothelial damage by binding to ACE2 and triggering [Ca2+]i through upregulation of Piezo1 and Orai1. …”
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