Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1 by Tamiris Azamor, Tamiris Azamor, Daniela Prado Cunha, Andréa Marques Vieira da Silva, Ohanna Cavalcanti de Lima Bezerra, Marcelo Ribeiro-Alves, Thyago Leal Calvo, Fernanda de Souza Gomes Kehdy, Fernanda Saloum de Neves Manta, Thiago Gomes de Toledo Pinto, Laís Pereira Ferreira, Elyzabeth Avvad Portari, Letícia da Cunha Guida, Leonardo Gomes, Maria Elisabeth Lopes Moreira, Elizeu Fagundes de Carvalho, Cynthia Chester Cardoso, Marcelo Muller, Ana Paula Dinis Ano Bom, Patrícia Cristina da Costa Neves, Zilton Vasconcelos, Milton Ozório Moraes

“…Here, we accessed samples from 153 pregnant women (77 without and 76 with CZS) and 143 newborns (77 without and 66 with CZS) exposed to ZIKV conducted a case-control study to verify whether interferon alfa receptor 1 (IFNAR1) and interferon lambda 2 and 4 (IFNL2/4) single nucleotide polymorphisms (SNPs) contribute to CZS outcome, and characterized placenta gene expression profile at term. …”
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Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants by Qiangzhen Yang, Xuemin Jian, Ali Alamdar Shah Syed, Aamir Fahira, Chenxiang Zheng, Zijia Zhu, Ke Wang, Jinmai Zhang, Yanqin Wen, Zhiqiang Li, Dun Pan, Tingting Lu, Zhuo Wang, Yongyong Shi

“…SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) has evolved many variants with stronger infectivity and immune evasion than the original strain, including Alpha, Beta, Gamma, Delta, Epsilon, Kappa, Iota, Lambda, and 21H strains. Amino acid mutations are enriched in the spike protein of SARS-CoV-2, which plays a crucial role in cell infection. …”
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MANIFESTAÇÕES HEMATOLÓGICAS AGUDAS DA LEISHMANIOSE VISCERAL COM INFILTRAÇÃO MEDULAR: RELATO DE CASO by WF Silva, HA Castralli, G Bellaver, A Zago, PM Mariussi, IR Pereira, CB Pacheco, OB Folin, LG Schmitt, KBM Mendes

“…Imunofenotipagem para avaliação dos plasmócitos mostrou 5.6% células plasmocitárias policlonais sem expressão aberrante, com fenótipo CD18/CD38, CD45/CD19+ e relação kappa/lambda preservada. Cariótipo normal 46XY. Teste rápido para leishmaniose positivo por imunocromatografia em 07/04, iniciando-se tratamento com Anfotericina B 500 mg IV, associada a Meropenem 1 g IV, Ivermectina 12 mg VO e Albendazol 400 mg VO. …”
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Cholecalciferol as a means of nonspecific immunoprophylaxis against COVID-19 by O. V. Berdiugina, E. Yu. Gusev

“…Similar differences were found for the IgM level (Wilks' Lambda: 0.659 approx. F (7.32) = 2.367 p < 0.045). …”
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Clinical and pathologic features of primary membranous nephropathy in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group by Abdulmecit Yildiz, Sena Ulu, Aysegul Oruc, Ali Riza Ucar, Savas Ozturk, Selma Alagoz, Necmi Eren, Ismail Kocyigit, Simal Koksal Cevher, Ali Burak Haras, Abdullah Sumnu, Turgay Arinsoy, Garip Sahin, Gultekin Suleymanlar, Caner Cavdar, Gizem Kumru Sahin, Ilhan Kurultak, Abdulkadir Unsal, Gulizar Sahin, Sinan Kazan, Erhan Tatar, Mehmet Dıkec, Belda Dursun, Hayriye Sayarlioglu, Kultigin Turkmen, Ayse Serra Artan, Nimet Aktas, Zulfikar Yilmaz, Ahmet Behlul, Hamad Dheir, Sim Kutlay, Nurhan Seyahi

“…The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. …”
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اللمفومات خارج العقدية والآفات المتعلقة بها by زهير الشهابي, رنا صالح

“…Specimens were obtained from endoscopic and surgical biopsies.To confirm the diagnosis; we used immunohistochemical stains for  LCA, CD 20, CD 3, CD43,CD10, BCL-2, Ki 67, Kappa and lambda light chains . Results: Among the 58 cases the most common site of extranodal lymphomas was the gastrointestinal tract, 41 cases, 27 involve the stomach, 14 involve the intestine. …”
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Reconstrucción mamaria en el Hospital S. Juan de Dios de Costa Rica: un estudio transversal Mammary reconstruction at the S. Juan de Dios Hospital, Costa Rica: a transversal study by G. Fonseca Portilla, S. Vargas Naranjo

“…A las complicaciones y la técnica quirúrgica se les realizó la prueba de λ² (Chi cuadrado) que fue significativa (p=0.003) y por tanto se descartó la dependencia entre las complicaciones y el procedimiento quirúrgico. …”
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LEUCEMIA LINFOIDE CRÔNICA FAMILIAR by MNCS Almeida, DF Siqueira, ACL Barros, NLR Corrêa, SA Gandra, OAL Alves, LA Neiva, WM Andrade, LGF Dias, JMC Roque

“…Marcadores negativos: CD10, CD22, CD103, IgM e Lambda. Os achados imunofenotípicos em associação aos citomorfológicos são compatíveis com leucemia linfocítica crônica, classificação OMS – 2016. …”
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LINFOMA PLASMABLÁSTICO EM PACIENTE HIV NEGATIVO: RELATO DE CASO by IDM Gonçalves, GO Borges, CCB Silva, RM Silva, AS Fujita, RMS Soares, JAS Abdon, FSB Ferreira, FD Xavier

“…Realizada biópsia da massa, a análise anatomopatológica evidenciou neoplasia pouco diferenciada positiva para CD138 com Ki67 60% e negativa para EBV, CD56, CD30, CD45, CD20, CD3, CD2. Os marcadores lambda e kappa foram inconclusivos. A sorologia para HIV foi negativa e eletroforese de proteínas e a imunofixação não detectaram pico monoclonal. …”
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CITOMEGALOVIROSE SISTÊMICA EM PACIENTE PORTADOR PÓS-TRANSPLANTE DE CÉLULAS-TRONCO AUTÓLOGO by MR Sagrilo, LPD Santos, G Bellaver, WF Silva, VG Weber, BBC Paula, JC Salvador, A Zago, GB Fischer

“…Resultados: Mulher, de 56 anos, portadora de Mieloma Múltiplo IgG/Lambda, em VGPR (Very Good Partial Response) foi submetida a TCTH autólogo após condicionamento com Melfalano 140 mg/m2. …”
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اللمفومات خارج العقدية والآفات المتعلقة بها by زهير الشهابي, رنا صالح

“…Specimens were obtained from endoscopic and surgical biopsies.To confirm the diagnosis; we used immunohistochemical stains for  LCA, CD 20, CD 3, CD43,CD10, BCL-2, Ki 67, Kappa and lambda light chains . Results: Among the 58 cases the most common site of extranodal lymphomas was the gastrointestinal tract, 41 cases, 27 involve the stomach, 14 involve the intestine. …”
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therap... by Kosgodage, Uchini S.

“…E. coli samples were treated with lambda phage with/without pre-treatment of Cl-am. …”
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Imagerie sismique d'un réservoir carbonaté : le dogger du Bassin parisien Seismic Imaging a Carbonate Reservoir: the Paris Basin Dogger by Mougenot D., Layotte P.

“…La sismique 2D dite haute résolution (HR) permet d'atteindre au niveau de l'objectif cette fréquence charnière qui fournit une résolution verticale suffisante pour que les réflexions situées au sommet et à la base du réservoir n'interfèrent pas (lambda/2 = 26 m). L'amplitude de ces réflexions est alors représentative des contrastes d'impédance de part et d'autre du réservoir et leurs variations latérales permettent de détecter des hétérogénéités, comme les variations de porosité, qui s'expriment bien acoustiquement. …”
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Ἡ χρονολογία τῆς ἀναγόρευσης καὶ τῆς στέψης τοῦ Θεοδώρου Α΄ τοῦ Λασκάρεως by Πάρις ΓΟΥΝΑΡΙΔΗΣ

“…L'auteur montre que: 1) la capture de Thierry de Los et de ses hommes, rapportée par Villehardouin n'est que la victoire du général de Théodore I Andronic Gidos, victoire qui, dans l'éloge de Nicetas Choniates, est attribuée au monarque de l'Etat nicéen. 2) L'expression de l'éloge τὸν τοῖχον ἐξαλεῖψαι καὶ τοὺς τοῦτον ἀλείφοντας est bien l'exigence de Théodore I que les Latins détruisent les ouvrages de défense construits dans la région de Nicomédie, pour conclure les trêves de Mai/Juin 1207. …”
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INFILTRAÇÃO DO SISTEMA NERVOSO CENTRAL POR CÉLULAS PLASMÁTICAS EM PACIENTE SEM COMPROVAÇÃO DE MIELOMA MÚLTIPLO – RELATO DE CASO by Ana Paula de Azambuja, Tatiana D. Scobel Balzani, Marina Couto Guedes, Ana Vitoria Cassis Santos Gasparine, Felipe Patricio, Elenaide Coutinho Nunes, Caroline Bonamin Sola

“…O exame de imunofenotipagem por citometria de fluxo confirmou a presença da população de plasmócitos de fenótipo anormal (CD38++, CD56++, CD45 fraco, CD117-/+) e clonal (restrição de cadeia Lambda). Todos as amostras de liquor foram negativas para antígenos tuberculose, criptococose, micológico direto, cultura BAAR, cultura de fungos e cultura de germes comuns. …”
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CITOMETRIA DE FLUXO MULTIPARAMÉTRICA DE SANGUE PERIFÉRICO E LINFONODOS COMO AUXILIAR NO DIAGNÓSTICO DE LINFOMA T ANGIOIMUNOBLÁSTICO by AP Azambuja, F Gevert, DC Oliveira, IS Barbosa, AP Percicote, PZ Rebutini, L Costa

“…Métodos: 273 amostras de LN foram avaliadas entre 2019 e 2023 com o tubo screening LST (CD8, CD56, CD5, CD3, CD38, CD4, CD20, CD45 e cadeias leves kappa e lambda). As amostras com alteração de fenótipo dos linfócitos T eram complementadas por tubos que incluíam os anticorpos monoclonais anti-CD2, CD7, CD10, CD25, CD26, CD27, CD28, CD45RA, CD45RO, CD57, CD94, CD279, receptor TCR gama-delta, e avaliação do receptor do TRCBeta com o clone JOVI1 partir de 2021. …”
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PERFIL IMUNOFENOTÍPICO DAS DOENÇAS LINFOPROLIFERATIVAS CRÔNICAS NO ESTADO DO RIO GRANDE DO NORTE, NORDESTE, BRASIL. by RD Lima, IAF Bahia, FCM Theodoro, GHM Oliveira, O Cabra-Marques, AD Luchessi, RDA Soares, MDGP Araújo, RE Martins, GBC Junior

“…Discussão: As DLPC-B são as mais comumente observadas correspondendo a mais de 85% de todos os casos e caracterizam-se pela presença de linfócitos B clonais com expressão de um único tipo de cadeia leve de imunoglobulina (kappa ou lambda) em proporção maior que 1/10, associou a forte positividade dos antígenos Pam-B como CD19, CD22 e CD20 e a ausência ou baixa expressão dos antígenos Pam-T. …”
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LEUCEMIA DE CÉLULAS PLASMOCITÁRIAS E SUA IMPORTÂNCIA NO DIAGNÓSTICO DIFERENCIAL DE LEUCOCITOSES by ACR Marques, LR Soares, VMR Souza, GMC Silva, GG Cunha, MLFB Dourado, MLRO Almeida, DV Markus, LAP Sales, WMT Braga

“…Entretanto, imunofenotipagem de sangue periférico evidenciou 86% de plasmócitos clonais que expressam os antígenos CD38 de elevada intensidade, CD138 e imunoglobulina de cadeia leve kappa intracitoplasmática, em associação à perda anômala do antígenos CD19 e CD45 e expressão negativa de CD56 e cadeia leve lambda (citop.), compatível com leucemia de plasmócitos. …”
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Black Hole Mass and Eddington-ratio Distributions of Less-luminous Quasars at z ∼ 4 in the Subaru Hyper Suprime-Cam Wide Field by Wanqiu He, Masayuki Akiyama, Motohiro Enoki, Kohei Ichikawa, Kohei Inayoshi, Nobunari Kashikawa, Toshihiro Kawaguchi, Yoshiki Matsuoka, Tohru Nagao, Masafusa Onoue, Taira Oogi, Andreas Schulze, Yoshiki Toba, Yoshihiro Ueda

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A Novel Bacterial Protease Inhibitor Adjuvant in RBD-Based COVID-19 Vaccine Formulations Containing Alum Increases Neutralizing Antibodies, Specific Germinal Center B Cells and Con... by Lorena M. Coria, Lucas M. Saposnik, Celeste Pueblas Castro, Eliana F. Castro, Eliana F. Castro, Laura A. Bruno, William B. Stone, Paula S. Pérez, Maria Laura Darriba, Lucia B. Chemes, Julieta Alcain, Ignacio Mazzitelli, Augusto Varese, Melina Salvatori, Albert J. Auguste, Albert J. Auguste, Diego E. Álvarez, Karina A. Pasquevich, Juliana Cassataro

“…Antibodies induced with the formulation containing U-Omp19 and alum not only increased their neutralization capacity against the ancestral virus but also cross-neutralized alpha, lambda, and gamma variants with similar potency. Furthermore, the addition of U-Omp19 to alum vaccine formulation increased the frequency of RBD-specific geminal center B cells and plasmablasts. …”
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