The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere by Gemma LM Fisher, César L Pastrana, Victoria A Higman, Alan Koh, James A Taylor, Annika Butterer, Timothy Craggs, Frank Sobott, Heath Murray, Matthew P Crump, Fernando Moreno-Herrero, Mark S Dillingham

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Innovation in gastrointestinal surgery: the evolution of minimally invasive surgery—a narrative review by Josephine Walshaw, Bright Huo, Adam McClean, Samantha Gajos, Jing Yi Kwan, Jing Yi Kwan, James Tomlinson, Chandra Shekhar Biyani, Safaa Dimashki, Ian Chetter, Marina Yiasemidou, Marina Yiasemidou

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Cost-effective sequence analysis of 113 genes in 1,192 probands with retinitis pigmentosa and Leber congenital amaurosis by Daan M. Panneman, Daan M. Panneman, Rebekkah J. Hitti-Malin, Rebekkah J. Hitti-Malin, Lara K. Holtes, Suzanne E. de Bruijn, Suzanne E. de Bruijn, Janine Reurink, Janine Reurink, Erica G. M. Boonen, Muhammad Imran Khan, Manir Ali, Sten Andréasson, Elfride De Baere, Elfride De Baere, Sandro Banfi, Sandro Banfi, Miriam Bauwens, Miriam Bauwens, Tamar Ben-Yosef, Béatrice Bocquet, Béatrice Bocquet, Marieke De Bruyne, Marieke De Bruyne, Berta de la Cerda, Frauke Coppieters, Frauke Coppieters, Frauke Coppieters, Pietro Farinelli, Thomas Guignard, Chris F. Inglehearn, Marianthi Karali, Marianthi Karali, Ulrika Kjellström, Robert Koenekoop, Robert Koenekoop, Bart de Koning, Bart P. Leroy, Bart P. Leroy, Bart P. Leroy, Bart P. Leroy, Martin McKibbin, Martin McKibbin, Isabelle Meunier, Isabelle Meunier, Konstantinos Nikopoulos, Koji M. Nishiguchi, James A. Poulter, Carlo Rivolta, Carlo Rivolta, Carlo Rivolta, Enrique Rodríguez de la Rúa, Patrick Saunders, Francesca Simonelli, Yasmin Tatour, Francesco Testa, Alberta A. H. J. Thiadens, Carmel Toomes, Anna M. Tracewska, Hoai Viet Tran, Hiroaki Ushida, Veronika Vaclavik, Virginie J. M. Verhoeven, Virginie J. M. Verhoeven, Maartje van de Vorst, Christian Gilissen, Christian Gilissen, Alexander Hoischen, Alexander Hoischen, Alexander Hoischen, Frans P. M. Cremers, Frans P. M. Cremers, Susanne Roosing, Susanne Roosing

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Editorial: Current trends in endoscopic thoracic surgery: insights from the XXI SIET national meeting by Federico Raveglia, Franca Melfi, Ugo Cioffi, Filippo Lococo, Sara Ricciardi, Cecilia Pompili, Giuseppe Cardillo

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P786: THROMBOSIS AND MENINGOCOCCAL INFECTION RATES IN PEGCETACOPLAN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA IN THE CLINICAL TRIAL AND POST-MARKETING SETTINGS by Richard Kelly, Hisakazu Nishimori, Regina Horneff, Peter Hillmen, Jessica Savage, Mohammed Al-Adhami, Stacie Lallier, Gloria Gerber

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37 Pathway to a controlled human infection model for Leishmania major by Vivak Parkash, Helen Ashwin, Georgina Jones, Jovana Sadlova, Barbora Vojtkova, Charles Jaffe, Petr Volf, Alison Layton, Paul Kaye, Charles Lacey

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P782: A PHASE 2, RANDOMIZED TRIAL EVALUATING THE SAFETY AND EFFICACY OF POZELIMAB AND CEMDISIRAN IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA by Jun-Ho Jang, Raymond Wong, Rodrigo Pavani, Lisa Aurand, Quang P. Nguyen, Lorah Perlee, Amal Souttou, Jonathan Weyne, Richard Kelly

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CD317-Positive Immune Stromal Cells in Human “Mesenchymal Stem Cell” Populations by Alasdair G. Kay, James M. Fox, James P. Hewitson, Andrew P. Stone, Sophie Robertson, Sally James, Xiao-nong Wang, Elizabeth Kapasa, Xuebin B. Yang, Paul G. Genever

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The global and regional impacts of climate change under representative concentration pathway forcings and shared socioeconomic pathway socioeconomic scenarios by N W Arnell, J A Lowe, D Bernie, R J Nicholls, S Brown, A J Challinor, T J Osborn

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Influence of acute fasting on pain tolerance in healthy subjects: a randomised crossover study by Sophie A. Edwards, Sarah L. Martin, Sarah L. Martin, Timothy Rainey, Grace Whitaker, Darren C. Greenwood, Anthony Jones, Manoj Sivan, Manoj Sivan

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Seizing the moment: The time for harnessing electronic patient-reported outcome measures for enhanced and sustainable metastatic breast cancer care is now by K.M. de Ligt, L.B. Koppert, B.H. de Rooij, L.V. van de Poll-Franse, G. Velikova, F. Cardoso

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A fast Fourier convolutional deep neural network for accurate and explainable discrimination of wheat yellow rust and nitrogen deficiency from Sentinel-2 time series data by Yue Shi, Liangxiu Han, Pablo González-Moreno, Darren Dancey, Wenjiang Huang, Zhiqiang Zhang, Yuanyuan Liu, Mengning Huang, Hong Miao, Min Dai

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The implications of defining obesity as a disease: a report from the Association for the Study of Obesity 2021 annual conference by Migena Luli, Giles Yeo, Emma Farrell, Jane Ogden, Helen Parretti, Emma Frew, Stephen Bevan, Adrian Brown, Jennifer Logue, Vinod Menon, Nadya Isack, Michael Lean, Chris McEwan, Paul Gately, Simon Williams, Nerys Astbury, Maria Bryant, Kenneth Clare, Georgios K. Dimitriadis, Graham Finlayson, Nicola Heslehurst, Brett Johnson, Sarah Le Brocq, Audrey Roberts, Patrick McGinley, Julia Mueller, Mary O'Kane, Rachel L. Batterham, Alexander Dimitri Miras

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COVID-19 and the role of health promoters and educators [version 2; peer review: 2 approved] by James Woodall

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P1474: HEMOLYTIC MARKERS, MORTALITY, AND THROMBOEMBOLIC EVENTS IN CAD: RISK ASSESSMENT BY TIME PERIOD SINCE DIAGNOSIS by Quentin A Hill, Wilma Barcellini, Alexander Röth, Alia Karaouni, Marion Afonso, Yoo Ronnie, Julien Tanniou, Julien Rubio, Catherine M Broome

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Editorial: Curbing carbon emissions: insight from the ecosystem evolution during ancient hyperthermal events by Wei Lin, Wei Lin, Mingtao Li, Mingtao Li, Wei Shi, Wei Shi, Wei Shi, Wei Shi

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Editorial: Understanding and Overcoming Biases in Judgment and Decision-Making With Real-Life Consequences by Yasmina Okan, Fernando Blanco, Dafina Petrova, Dafina Petrova, Dafina Petrova, Monica Capra, José C. Perales, José C. Perales

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Editorial: Freshwater biodiversity crisis: Multidisciplinary approaches as tools for conservation by Felipe Polivanov Ottoni, Josie South, Valter M. Azevedo-Santos, Valter M. Azevedo-Santos, Valter M. Azevedo-Santos, Elisabeth Henschel, Pedro Henrique Negreiros de Bragança

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A synthetic Longitudinal Study dataset for England and Wales by Adam Dennett, Paul Norman, Nicola Shelton, Rachel Stuchbury

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Editorial: Energy materials based novel solar thermal applications by Muhammad Amjad, Muhammad Amjad, Enio Pedone Bandarra Filho, Shafiq Ahmad, Fahid Riaz, Muhammad Abdul Qyyum, Yanwei Hu, Jabbar Gardy

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