Congenital myasthenic syndrome with tubular aggregates caused by GFPT1 mutations. door Guergueltcheva, V, Müller, J, Dusl, M, Senderek, J, Oldfors, A, Lindbergh, C, Maxwell, S, Colomer, J, Mallebrera, C, Nascimento, A, Vilchez, J, Muelas, N, Kirschner, J, Nafissi, S, Kariminejad, A, Nilipour, Y, Bozorgmehr, B, Najmabadi, H, Rodolico, C, Sieb, J, Schlotter, B, Schoser, B, Herrmann, R, Voit, T, Steinlein, O

“…In most patients with GFPT1 mutations, onset of the disease occurs in the first decade of life with characteristic limb-girdle weakness and fatigue. …”

Phase 2 of CATALISE: a multinational and multidisciplinary Delphi consensus study of problems with language development: Terminology door Bishop, D, Snowling, M, Thompson, P, Greenhalgh, T, CATALISE-2 consortium

“…The term ‘Language Disorder’ is recommended to refer to a profile of difficulties that causes functional impairment in everyday life and is associated with poor prognosis. The term, ‘Developmental Language Disorder’ (DLD) was endorsed for use when the language disorder was not associated with a known biomedical aetiology. …”

Deoxyspergualin in relapsing and refractory Wegener's granulomatosis. door Flossmann, O, Baslund, B, Bruchfeld, A, Tervaert, J, Hall, C, Heinzel, P, Hellmich, B, Luqmani, R, Nemoto, K, Tesar, V, Jayne, DR

“…Relapses occurred in 18 (43%) patients after a median of 170 (44-316) days after achieving remission. Severe or life-threatening (> or = grade 3) treatment-related adverse events occurred in 24 (53%) patients mostly due to leucopaenias. …”

Natural enemies and the diversity of plant communities door Jeffs, C

“…Overall, my results provide evidence that pre-dispersal seed predators and soil fungi can affect plant recruitment and diversity at early life stages, with potential consequences for the community structure of adult plants.…”

Congenital Cytomegalovirus Infection as a Cause of Sensorineural Hearing Loss in a Highly Immune Population door Wang, K, Chalker, V, Bermingham, A, Harrison, T, Mant, D, Harnden, A

“…<br/> <b>Methods:</b> Newborns with positive saliva CMV-DNA that was confirmed by virus isolation in the first 2 weeks of life were enrolled in a prospective follow-up study to monitor hearing outcome.…”

Patient weighting of importance of asthma symptoms. door Osman, L, McKenzie, L, Cairns, J, Friend, J, Godden, D, Legge, J, Douglas, J

“…BACKGROUND: Quality of life measures are increasingly important in evaluating outcomes in asthma. …”

Trans-cutaneous electrical nerve stimulation to treat dry mouth (xerostomia) following radiotherapy for head and neck cancer. A systematic review door Salimi, F, Saavedra, F, Andrews, B, FitzGerald, J, Winter, SC

“…Background<br> A dry mouth or xerostomia is one of the most common long-term complications following radiotherapy for head and neck cancer and has a negative impact on quality of life in cancer survivors. Transcutaneous electrical nerve stimulation (TENS) is a novel approach to improving saliva flow in these patients. …”

‘Better active today than radioactive tomorrow!’ : transnational opposition to nuclear energy in France and West Germany, 1968-1981 door Tompkins, A

“…Residents of towns near planned power stations felt that nuclear technology represented an intervention in their community by state and industry, a potential threat to their health, wealth and way of life. In the decade after 1968, concerns like these coalesced with criticisms of capitalism, the state, militarism and consumer society that were being made by a more politicised constituency. …”

Early behavioural facilitation by temporal expectations in complex visual-motor sequences door Heideman, S, van Ede, F, Nobre, A

“…In daily life, temporal expectations may derive from incidental learning of recurring patterns of intervals. …”

A meta-analysis of local adaptation in plants door Leimu, R, Fischer, M

“…The degree of local adaptation was independent of plant life history, spatial or temporal habitat heterogeneity, and geographic scale. …”

Social inequalities in mental disorders and substance misuse in young adults. A birth cohort study in Southern Brazil door Barros, F, Matijasevich, A, Santos, I, Horta, B, da Silva, B, Munhoz, T, Fazel, S, Stein, A, Pearson, R, Anselmi, L, Rohde, L

“…</p><p> Conclusions: The high rates of mental disorders and lifetime suicide attempts in young adults, especially those who were always poor or became poor after childhood, suggest that recent socioeconomic-related stressful situations may have a higher impact on the current mental health than events earlier in life. However, we could not identify at what specific ages socioeconomic changes were more important.…”

Peripheral neuropathy in ANCA-associated vasculitis: outcomes from the European Vasculitis Study Group trials. door Suppiah, R, Hadden, R, Batra, R, Arden, N, Collins, M, Guillevin, L, Jayne, DR, Luqmani, R

“…CONCLUSION: Peripheral neuropathy is an occasional accompaniment of AAV that typically remits in concert with non-neuropathic manifestations, usually involves motor nerves, often produces long-lasting symptoms and is not associated with life-threatening organ involvement.…”

Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. door Miotla, J, Maciewicz, R, Kendrew, J, Feldmann, M, Paleolog, E

“…To block VEGF activity, animals were treated after arthritis onset with a soluble form of the Flt-1 VEGF receptor (sFlt), which was polyethylene glycol (PEG)-linked to increase its in vivo half-life. Treatment of arthritic mice with sFlt-PEG significantly reduced both clinical score and paw swelling, compared with untreated or control-treated (heat-denatured sFlt-PEG) animals. …”

Adjuvant radiotherapy for stage i endometrial cancer: An updated cochrane systematic review and meta-analysis door Kong, A, Johnson, N, Kitchener, H, Lawrie, T

“…EBRT was associated with an increased risk of severe acute toxicity, severe late toxicity, and reduced quality of life scores. © 2012 The Author 2012.…”

Reformed sacramental piety in England 1590-1630 door Jones, C

“…First they were concerned to outline the ‘qualities’ of a ‘worthy’ receiver of the Lord’s Supper, foremost amongst which were knowledge, faith, newness of life and repentance. Second they tended to divide the concept of worthiness into three temporal chunks comprising the times before, during, and after the Supper.…”

Risk factors for anogenital cancers in postmenopausal women: the Million Women Study door Coffey, CJ

“…Past high-grade cervical abnormalities are a marker of increased risk of subsequent anogenital cancer, but only a small proportion of women with such a history go on to develop anal, vulval or vaginal cancer later in life.</p>…”

Platelet rich plasma versus placebo for the management of Achilles tendinopathy: protocol for the UK study of Achilles tendinopathy management (ATM) multi-centre randomised trial door Kearney, RS, Parsons, N, Ji, C, Warwick, J, Brown, J, Young, J, Costa, ML

“…A minimum of 240 patients will be recruited into the study; this number will provide 90% power to detect a difference of 12 points in Victorian Institute of Sport Assessment-Achilles score at 6 months. Quality of life, pain and complications data will be collected at baseline, 2-week, 3-month and 6-month post-randomisation. …”

Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic door Attah, V, Milner, DS, Fang, Y, Yan, X, Leonard, G, Heitman, J, Talbot, NJ, Richards, TA

“…Oomycetes are heterotrophic protists that share phenotypic similarities with fungi, including the ability to cause plant diseases, but branch in a separate and distant region of the eukaryotic tree of life. It has been suggested that multiple horizontal gene transfers (HGTs) from fungi-to-oomycetes contributed to the evolution of plant-pathogenic traits. …”

Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): A randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic... door Dudareva, M, Kümin, M, Vach, W, Kaier, K, Ferguson, J, McNally, M, Scarborough, M

“…Secondary outcomes will include probable and definite treatment failure, serious adverse events, treatment side effects, quality of life scores and cost analysis. DISCUSSION:This study aims to assess a treatment strategy that may enable the reduction of systemic antibiotic use for patients with orthopaedic infection. …”

Gottfried Leibniz in his world: the making of a Savant (1672-1679) door Borowski, A

“…This part examines how he took advantage of the city’s cultural life, moving in multiple intellectual and scientific circles, partaking in the intellectual debates of the time, gathering information, inventing the calculus and his calculating machine, advocating his scientific agenda at court, and promoting both scientific societies and various technological and commercial ventures in the hope—disappointed—of securing a position at the Académie des Sciences.…”