PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle by Mohaned Benzarti, Laura Neises, Anais Oudin, Christina Krötz, Elodie Viry, Ernesto Gargiulo, Coralie Pulido, Maryse Schmoetten, Vitaly Pozdeev, Nadia I. Lorenz, Michael W. Ronellenfitsch, David Sumpton, Marc Warmoes, Christian Jaeger, Antoine Lesur, Björn Becker, Etienne Moussay, Jerome Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser

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The Translational Data Catalog - discoverable biomedical datasets by Danielle Welter, Philippe Rocca-Serra, Valentin Grouès, Nirmeen Sallam, François Ancien, Abetare Shabani, Saeideh Asariardakani, Pinar Alper, Soumyabrata Ghosh, Tony Burdett, Susanna-Assunta Sansone, Wei Gu, Venkata Satagopam

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P598: DISRUPTION IN ONE-CARBON METABOLISM THROUGH MTHFD1 INHIBITION AS NOVEL THERAPEUTIC STRATEGY IN CHRONIC LYMPHOCYTIC LEUKEMIA by Elodie Viry, Chloé Duculty, Nicole Kiweler, Coralie Pulido, Anais Oudin, Ana Slipicevic, Martin Henriksson, Johannes Meise, Thomas Helleday, Etienne Moussay, Jérôme Paggetti

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Formate promotes invasion and metastasis in reliance on lipid metabolism by Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser

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Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells by Anna S. Monzel, Lisa M. Smits, Kathrin Hemmer, Siham Hachi, Edinson Lucumi Moreno, Thea van Wuellen, Javier Jarazo, Jonas Walter, Inga Brüggemann, Ibrahim Boussaad, Emanuel Berger, Ronan M.T. Fleming, Silvia Bolognin, Jens C. Schwamborn

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A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance by Alexander Mazein, Marcio Luis Acencio, Irina Balaur, Adrien Rougny, Danielle Welter, Anna Niarakis, Anna Niarakis, Diana Ramirez Ardila, Ugur Dogrusoz, Piotr Gawron, Venkata Satagopam, Venkata Satagopam, Wei Gu, Wei Gu, Andreas Kremer, Reinhard Schneider, Reinhard Schneider, Marek Ostaszewski, Marek Ostaszewski

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Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response by Tijana Randic, Stefano Magni, Demetra Philippidou, Christiane Margue, Kamil Grzyb, Jasmin Renate Preis, Joanna Patrycja Wroblewska, Petr V. Nazarov, Michel Mittelbronn, Katrin B.M. Frauenknecht, Alexander Skupin, Stephanie Kreis

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Comparison of two protocols for the generation of iPSC-derived human astrocytes by Patrycja Mulica, Carmen Venegas, Zied Landoulsi, Katja Badanjak, Sylvie Delcambre, Maria Tziortziou, Soraya Hezzaz, Jenny Ghelfi, Semra Smajic, Jens Schwamborn, Rejko Krüger, Paul Antony, Patrick May, Enrico Glaab, Anne Grünewald, Sandro L. Pereira

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Guided by humanitarian principles by Vogt, A, Colsell, S

“…Caritas Luxembourg’s work with refugees, IDPs and migrants in Colombia, Lebanon and Luxembourg offers some examples of the ways in which a faith-based organisation may be advantaged or disadvantaged by its faith basis and how it needs to adhere to humanitarian standards…”

Onboard Processing in Satellite Communications Using AI Accelerators by Flor Ortiz, Victor Monzon Baeza, Luis M. Garces-Socarras, Juan A. Vásquez-Peralvo, Jorge L. Gonzalez, Gianluca Fontanesi, Eva Lagunas, Jorge Querol, Symeon Chatzinotas

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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G > A (p.R2... by Axel Chemla, Giuseppe Arena, Gizem Onal, Jonas Walter, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Jens C. Schwamborn, Rejko Krüger

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Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson’s Disease Point Mutation A30P... by Peter Barbuti, Paul Antony, Bruno Santos, François Massart, Gérald Cruciani, Claire Dording, Jonathan Arias, Jens Schwamborn, Rejko Krüger

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Altered infective competence of the human gut microbiome in COVID-19 by Laura de Nies, Valentina Galata, Camille Martin-Gallausiaux, Milena Despotovic, Susheel Bhanu Busi, Chantal J. Snoeck, Lea Delacour, Deepthi Poornima Budagavi, Cédric Christian Laczny, Janine Habier, Paula-Cristina Lupu, Rashi Halder, Joëlle V. Fritz, Taina Marques, Estelle Sandt, Marc Paul O’Sullivan, Soumyabrata Ghosh, Venkata Satagopam, CON-VINCE Consortium, Rejko Krüger, Guy Fagherazzi, Markus Ollert, Feng Q. Hefeng, Patrick May, Paul Wilmes

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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.1290A > G (p.T... by Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Christine Klein, Philip Seibler, Jens C. Schwamborn, Rejko Krüger

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Retrograde procedural memory is impaired in people with Parkinson’s disease with freezing of gait by Laure Pauly, Laure Pauly, Laure Pauly, Laure Pauly, Claire Pauly, Claire Pauly, Claire Pauly, Maxime Hansen, Maxime Hansen, Maxime Hansen, Valerie E. Schröder, Valerie E. Schröder, Armin Rauschenberger, Anja K. Leist, Rejko Krüger, Rejko Krüger, Rejko Krüger

“…Previous studies hypothesized that FOG may be due to a loss of automaticity.Research questionTo explore whether FOG is associated with impairment in cognitive functions, focusing on retrograde procedural memory, the memory responsible for the automatic, implicit stored procedures that have been acquired in earlier life stages.MethodsIn this cross-sectional, case–control study, 288 people with typical Parkinson’s disease (PD) from the Luxembourg Parkinson’s Study were assigned to Freezers (FOG+) and non-Freezers (FOG−) based on the MDS-UPDRS 2.13 (self-reported FOG episodes) and 3.11 (FOG evaluated by clinicians during gait assessment). …”
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Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency by Yolanda Pires‐Afonso, Arnaud Muller, Kamil Grzyb, Anaïs Oudin, Yahaya A. Yabo, Carole Sousa, Andrea Scafidi, Aurélie Poli, Antonio Cosma, Rashi Halder, Djalil Coowar, Anna Golebiewska, Alexander Skupin, Simone P. Niclou, Alessandro Michelucci

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A systematic approach to managing complications after proximal tibial osteotomies of the knee by Jérôme Valcarenghi, Giulio Vittone, Caroline Mouton, Alexandre Coelho Leal, Maximiliano Ibañez, Alexander Hoffmann, Dietrich Pape, Matthieu Ollivier, Romain Seil

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Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges by Muhammad Zaeem Noman, Meriem Hasmim, Audrey Lequeux, Malina Xiao, Caroline Duhem, Salem Chouaib, Guy Berchem, Bassam Janji

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Hybrid Silica-Based Fillers in Nanocomposites: Influence of Isotropic/Isotropic and Isotropic/Anisotropic Fillers on Mechanical Properties of Styrene-Butadiene (SBR)-Based Rubber by Mariapaola Staropoli, Vincent Rogé, Enzo Moretto, Joffrey Didierjean, Marc Michel, Benoit Duez, Pascal Steiner, Georges Thielen, Damien Lenoble, Jean-Sébastien Thomann

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Early-to-mid stage idiopathic Parkinson’s disease shows enhanced cytotoxicity and differentiation in CD8 T-cells in females by Christophe M. Capelle, Séverine Ciré, Fanny Hedin, Maxime Hansen, Lukas Pavelka, Kamil Grzyb, Dimitrios Kyriakis, Oliver Hunewald, Maria Konstantinou, Dominique Revets, Vera Tslaf, Tainá M. Marques, Clarissa P. C. Gomes, Alexandre Baron, Olivia Domingues, Mario Gomez, Ni Zeng, Fay Betsou, Patrick May, Alexander Skupin, Antonio Cosma, Rudi Balling, Rejko Krüger, Markus Ollert, Feng Q. Hefeng

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