No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in <i>MLH1</i> and <i>MSH2</i>: A Prospective Lynch Syndrome Database Study by Mev Dominguez-Valentin, John-Paul Plazzer, Julian R. Sampson, Christoph Engel, Stefan Aretz, Mark A. Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Finlay Macrae, Ingrid M. Winship, Huw Thomas, Dafydd Gareth Evans, John Burn, Marc Greenblatt, Wouter H. de Vos tot Nederveen Cappel, Rolf H. Sijmons, Maartje Nielsen, Lucio Bertario, Bernardo Bonanni, Maria Grazia Tibiletti, Giulia Martina Cavestro, Annika Lindblom, Adriana Della Valle, Francisco Lopez-Kostner, Karin Alvarez, Nathan Gluck, Lior Katz, Karl Heinimann, Carlos A. Vaccaro, Sigve Nakken, Eivind Hovig, Kate Green, Fiona Lalloo, James Hill, Hans F. A. Vasen, Claudia Perne, Reinhard Büttner, Heike Görgens, Elke Holinski-Feder, Monika Morak, Stefanie Holzapfel, Robert Hüneburg, Magnus von Knebel Doeberitz, Markus Loeffler, Nils Rahner, Jürgen Weitz, Verena Steinke-Lange, Wolff Schmiegel, Deepak Vangala, Emma J. Crosbie, Marta Pineda, Matilde Navarro, Joan Brunet, Leticia Moreira, Ariadna Sánchez, Miquel Serra-Burriel, Miriam Mints, Revital Kariv, Guy Rosner, Tamara Alejandra Piñero, Walter Hernán Pavicic, Pablo Kalfayan, Sanne W. ten Broeke, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Päivi Peltomäki, John L. Hopper, Aung Ko Win, Daniel D. Buchanan, Noralane M. Lindor, Steven Gallinger, Loïc Le Marchand, Polly A. Newcomb, Jane C. Figueiredo, Stephen N. Thibodeau, Christina Therkildsen, Thomas V. O. Hansen, Lars Lindberg, Einar Andreas Rødland, Florencia Neffa, Patricia Esperon, Douglas Tjandra, Gabriela Möslein, Toni T. Seppälä, Pål Møller

“…Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. …”
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Prognostic value of Lynch syndrome, BRAFV600E, and RAS mutational status in dMMR/MSI‐H metastatic colorectal cancer in a pooled analysis of Dutch and French cohorts by Koen Zwart, Frederieke H. van derBaan, Romain Cohen, Thomas Aparicio, Christelle de laFouchardiére, Thierry Lecomte, Cornelis J. A. Punt, David Sefrioui, Rik J. Verheijden, Geraldine R. Vink, G. Emerens Wensink, Aziz Zaanan, Miriam Koopman, David Tougeron, Jeanine M. L. Roodhart

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Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient by Erica Torchiaro, Consalvo Petti, Sabrina Arena, Sabrina Arena, Francesco Sassi, Giorgia Migliardi, Alfredo Mellano, Roberta Porporato, Marco Basiricò, Loretta Gammaitoni, Enrico Berrino, Enrico Berrino, Monica Montone, Giorgio Corti, Giovanni Crisafulli, Caterina Marchiò, Caterina Marchiò, Alberto Bardelli, Alberto Bardelli, Enzo Medico, Enzo Medico

Subjects: “…Lynch syndrome…”
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<i>BRAF</i> and <i>MLH1</i> Analysis Algorithm for the Evaluation of Lynch Syndrome Risk in Colorectal Carcinoma Patients: Evidence-Based Data from the Analysis of 100 Consecutive Cases by Thais Maloberti, Antonio De Leo, Viviana Sanza, Lidia Merlo, Michela Visani, Giorgia Acquaviva, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Stefano Zagnoni, Daniela Turchetti, Sara Miccoli, Michelangelo Fiorentino, Antonietta D’Errico, Dario de Biase, Giovanni Tallini

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A new mutL homolog 1 c.1896+5G>A germline mutation detected in a Lynch syndrome‐associated lung and gastric double primary cancer patient by Xuyuan Chen, Xiang Li, Hongsen Liang, Lichun Wei, Qiang Cui, Ming Yao, Xu Wu

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Case report: Reproductive organ preservation and subsequent pregnancy for an infertility patient with lynch syndrome-associated synchronous endometrial cancer and colon cancer after treatment with a PD-1 checkpoint inhibitor by Di Cao, Di Cao, Yu Gao, Rong-xin Zhang, Rong-xin Zhang, Fu-long Wang, Fu-long Wang, Cong Li, Cong Li, Miao-qing Wu, Miao-qing Wu, Yi-fan Liu, Yi-fan Liu, Dan-dan Li, Dan-dan Li, Gong Chen, Gong Chen

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Association of a novel point mutation in MSH2 gene with familial multiple primary cancers by Hai Hu, Hong Li, Feng Jiao, Ting Han, Meng Zhuo, Jiujie Cui, Yixue Li, Liwei Wang

Subjects: “…Lynch syndrome…”
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Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study by Dinisha Einstien, Gayathri Devi Thanigaimani, KS Mouleeswaran, A Prathiba, G Sarumathy, John Vergilin

Subjects: “…lynch syndrome…”
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Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review by Zeinab Abdollahi, Mohammad Amin Tabatabaiefar, Mohammad Hassan Emami, Mehrdad Zeinalian

Subjects: “…lynch syndrome…”
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Colorectal Cancer: Epidemiological Trends, Screening, and Inheritability by Isabela Andhika Paramita, Hasan Maulahela, Kevin Winston

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Beyond germline genetic testing - heterozygous pathogenic variants in PMS2 in two children with Osteosarcoma and Ependymoma by Michaela Kuhlen, Mariola Monika Golas, Tina Schaller, Nicole Stadler, Felicitas Maier, Olaf Witt, Michael C. Frühwald

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Cyberknife Radiosurgery for Prostate Cancer after Abdominoperineal Resection (CYRANO): The Combined Computer Tomography and Electromagnetic Navigation Guided Transperineal Fiducial... by Andrea Vavassori, Giovanni Mauri, Giovanni Carlo Mazzola, Federico Mastroleo, Guido Bonomo, Stefano Durante, Dario Zerini, Giulia Marvaso, Giulia Corrao, Elettra Dorotea Ferrari, Elena Rondi, Sabrina Vigorito, Federica Cattani, Franco Orsi, Barbara Alicja Jereczek-Fossa

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Epidemiology, Risk Factors and Diagnosis of Small Bowel Adenocarcinoma by Thomas Aparicio, Atanas Pachev, Pierre Laurent-Puig, Magali Svrcek

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Complete Loss of EPCAM Immunoexpression Identifies <i>EPCAM</i> Deletion Carriers in MSH2-Negative Colorectal Neoplasia by Míriam Cuatrecasas, Iñigo Gorostiaga, Cristina Riera, Esteban Saperas, Gemma Llort, Irmgard Costa, Xavier Matias-Guiu, Cristina Carrato, Matilde Navarro, Marta Pineda, Núria Dueñas, Joan Brunet, Vicente Marco, Isabel Trias, José Ignacio Busteros, Gemma Mateu, Francesc Balaguer, María-Teresa Fernández-Figueras, Manel Esteller, Eva Musulén

Subjects: “…lynch syndrome…”
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Mismatch Repair Universal Screening of Endometrial Cancers (MUSE) in a Canadian Cohort by Jessica Lawrence, Lara Richer, Jocelyne Arseneau, Xing Zeng, George Chong, Evan Weber, William Foulkes, Laura Palma

Subjects: “…lynch syndrome…”
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The Prevalence of Pathogenic or Likely Pathogenic Germline Variants in a Nationwide Cohort of Young Colorectal Cancer Patients Using a Panel of 18 Genes Associated with Colorectal... by Erik Frostberg, Annabeth Høgh Petersen, Anders Bojesen, Hans Bjarke Rahr, Jan Lindebjerg, Karina Rønlund

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Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency by Romain Cohen, Raphaël Colle, Thomas Pudlarz, Maximilien Heran, Alex Duval, Magali Svrcek, Thierry André

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1526 Nous-209 genetic vaccine encoding shared cancer neoantigens is safe and elicits robust immune response in healthy Lynch syndrome carriers: interim results from Phase 1 cancer interception trial by Asad Umar, Jack Lee, Diane Liu, Eduardo Vilar, Ellen Richmond, Powel H Brown, Laura Antonucci, Marcia Cruz-Correa, Michael J Hall, Guido Leoni, Gabriella Cotugno, Irene Garzia, Elisa Scarselli, Araceli Garcia-Gonzalez, Loredana Siani, Sven Gogov, Laura Reyes Uribe, Morena D’Alise, Jason Willis, Gregory E Idos, Lana A Vornik, Luz Maria Rodriguez

Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer by Giorgia Mori, Maria Rosalia Pasca

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Unexplained mismatch repair deficiency: Case closed by Ellis L. Eikenboom, Sarah Moen, Lotte van Leeuwen, Willemina R.R. Geurts-Giele, Carli M.J. Tops, Tjakko J. van Ham, Winand N.M. Dinjens, Hendrikus J. Dubbink, Manon C.W. Spaander, Anja Wagner

Subjects: “…Lynch syndrome…”
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