Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential by Ana Cvetko, Domagoj Kifer, Olga Gornik, Lucija Klarić, Elizabeth Visser, Gordan Lauc, James F. Wilson, Tamara Štambuk

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Gene-based whole genome sequencing meta-analysis of 250 circulating proteins in three isolated European populations by Arthur Gilly, Lucija Klaric, Young-Chan Park, Grace Png, Andrei Barysenka, Joseph A. Marsh, Emmanouil Tsafantakis, Maria Karaleftheri, George Dedoussis, James F. Wilson, Eleftheria Zeggini

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Acetylation reprograms MITF target selectivity and residence time by Pakavarin Louphrasitthiphol, Alessia Loffreda, Vivian Pogenberg, Sarah Picaud, Alexander Schepsky, Hans Friedrichsen, Zhiqiang Zeng, Anahita Lashgari, Benjamin Thomas, E. Elizabeth Patton, Matthias Wilmanns, Panagis Filippakopoulos, Jean-Philippe Lambert, Eiríkur Steingrímsson, Davide Mazza, Colin R. Goding

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An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning by Ingrid Ehrmann, James H Crichton, Matthew R Gazzara, Katherine James, Yilei Liu, Sushma Nagaraja Grellscheid, Tomaž Curk, Dirk de Rooij, Jannetta S Steyn, Simon Cockell, Ian R Adams, Yoseph Barash, David J Elliott

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Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health by Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Liu Shi, Aleks Stolicyn, Neil A. Robertson, Rosie M. Walker, Robert I. McGeachan, Archie Campbell, Shen Xueyi, Miruna C. Barbu, Claire Green, Stewart W. Morris, Mathew A. Harris, Ellen V. Backhouse, Joanna M. Wardlaw, J. Douglas Steele, Diego A. Oyarzún, Graciela Muniz-Terrera, Craig Ritchie, Alejo Nevado-Holgado, Tamir Chandra, Caroline Hayward, Kathryn L. Evans, David J. Porteous, Simon R. Cox, Heather C. Whalley, Andrew M. McIntosh, Riccardo E. Marioni

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Genome-Wide Association Analysis and Genomic Prediction of Thyroglobulin Plasma Levels by Nikolina Pleić, Mirjana Babić Leko, Ivana Gunjača, Thibaud Boutin, Vesela Torlak, Antonela Matana, Ante Punda, Ozren Polašek, Caroline Hayward, Tatijana Zemunik

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The <i>Dct^−/−</i> Mouse Model to Unravel Retinogenesis Misregulation in Patients with Albinism by Angèle Tingaud-Sequeira, Elina Mercier, Vincent Michaud, Benoît Pinson, Ivet Gazova, Etienne Gontier, Fanny Decoeur, Lisa McKie, Ian J. Jackson, Benoît Arveiler, Sophie Javerzat

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Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease by Chris Armit

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Author Correction: Clinically-relevant postzygotic mosaicism in parents and children with developmental disorders in trio exome sequencing data by C. F. Wright, E. Prigmore, D. Rajan, J. Handsaker, J. McRae, J. Kaplanis, T. W. Fitzgerald, D. R. FitzPatrick, H. V. Firth, M. E. Hurles

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Mechanisms of Photoreceptor Death in Retinitis Pigmentosa by Fay Newton, Roly Megaw

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Higher-Order Interactions and Their Duals Reveal Synergy and Logical Dependence beyond Shannon-Information by Abel Jansma

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Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma by Andrew R. Hamel, Wenjun Yan, John M. Rouhana, Aboozar Monovarfeshani, Xinyi Jiang, Puja A. Mehta, Jayshree Advani, Yuyang Luo, Qingnan Liang, Skanda Rajasundaram, Arushi Shrivastava, Katherine Duchinski, Sreekar Mantena, Jiali Wang, Tavé van Zyl, Louis R. Pasquale, Anand Swaroop, Puya Gharahkhani, Anthony P. Khawaja, Stuart MacGregor, International Glaucoma Genetics Consortium (IGGC), Rui Chen, Veronique Vitart, Joshua R. Sanes, Janey L. Wiggs, Ayellet V. Segrè

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Ageing compromises mouse thymus function and remodels epithelial cell differentiation by Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer

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Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances by Paul RHJ Timmers, Ninon Mounier, Kristi Lall, Krista Fischer, Zheng Ning, Xiao Feng, Andrew D Bretherick, David W Clark, eQTLGen Consortium, Xia Shen, Tõnu Esko, Zoltán Kutalik, James F Wilson, Peter K Joshi

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Updated benchmarking of variant effect predictors using deep mutational scanning by Benjamin J Livesey, Joseph A Marsh

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Integrated molecular characterisation of endometrioid ovarian carcinoma identifies opportunities for stratification by Robert L. Hollis, Barbara Stanley, John P. Thomson, Michael Churchman, Ian Croy, Tzyvia Rye, Clare Bartos, Fiona Nussey, Melanie Mackean, Alison M. Meynert, Colin A. Semple, Charlie Gourley, C. Simon Herrington

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MITF reprograms the extracellular matrix and focal adhesion in melanoma by Ramile Dilshat, Valerie Fock, Colin Kenny, Ilse Gerritsen, Romain Maurice Jacques Lasseur, Jana Travnickova, Ossia M Eichhoff, Philipp Cerny, Katrin Möller, Sara Sigurbjörnsdóttir, Kritika Kirty, Berglind Ósk Einarsdottir, Phil F Cheng, Mitchell Levesque, Robert A Cornell, E Elizabeth Patton, Lionel Larue, Marie de Tayrac, Erna Magnúsdóttir, Margrét Helga Ögmundsdóttir, Eirikur Steingrimsson

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Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations by Benjamin J Livesey, Joseph A Marsh

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Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene by Katherine A. Kentistou, Jian’an Luan, Laura B. L. Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R. Speakman, Nicholas J. Wareham, Timothy J. Kendall, Claudia Langenberg, James F. Wilson, Peter K. Joshi, Nicholas M. Morton

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Comparison of T-cell receptor diversity of people with myalgic encephalomyelitis versus controls by Joshua J Dibble, Ben Ferneyhough, Matthew Roddis, Sam Millington, Michael D Fischer, Nick J Parkinson, Chris P Ponting

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