Sulfonamides with Heterocyclic Periphery as Antiviral Agents by Mikhail Yu. Moskalik

“…This review provides examples of the synthesis of sulfonamide compounds with antiviral properties that can be used to develop drugs against coxsackievirus B, enteroviruses, encephalomyocarditis viruses, adenoviruses, human parainfluenza viruses, Ebola virus, Marburg virus, SARS-CoV-2, HIV and others. Since over the past three years, viral infections have become a special problem for public health throughout the world, the development of new broad-spectrum antiviral drugs is an extremely important task for synthetic organic and medicinal chemistry. …”
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Establishment of Intestinal Organoid from <i>Rousettus leschenaultii</i> and the Susceptibility to Bat-Associated Viruses, SARS-CoV-2 and Pteropine Orthoreovirus by Mohamed Elbadawy, Yuki Kato, Nagisa Saito, Kimika Hayashi, Amira Abugomaa, Mio Kobayashi, Toshinori Yoshida, Makoto Shibutani, Masahiro Kaneda, Hideyuki Yamawaki, Tetsuya Mizutani, Chang-Kweng Lim, Masayuki Saijo, Kazuaki Sasaki, Tatsuya Usui, Tsutomu Omatsu

“…Various pathogens, such as Ebola virus, Marburg virus, Nipah virus, Hendra virus, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and SARS-CoV-2, are threatening human health worldwide. …”
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Bioinformatic, Biochemical, and Immunological Mining of MHC Class I Restricted T Cell Epitopes for a Marburg Nucleoprotein Microparticle Vaccine by Paul E. Harris, Scott Burkholz, Charles V. Herst, Reid M. Rubsamen

“…The Marburg virus (MARV), the virus responsible for Marburg hemorrhagic fever (MHF), is considered a top-priority pathogen for vaccine development. …”
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Structural, chemical reactivity, topological, electronic and spectroscopic (Raman, SERS and UV-Vis) and antiviral investigation of Furo [3,2-c] pyridine-2-carbaldehyde by Sravanthi R, S Mahalakshmi, V Vetrivelan, S Sakthivel, S Kumaran, S Muthu

“…The compound's antiviral efficacy against viruses such as Machupo virus and Marburg virus is demonstrated via protein-ligand docking.…”
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A multi-filovirus vaccine candidate: Co-expression of ebola, Sudan, and Marburg antigens in a single vector by Sebastian, S, Flaxman, A, Cha, KM, Ulaszewska, M, Gilbride, C, Sharpe, H, Wright, E, Spencer, AJ, Dowall, S, Hewson, R, Gilbert, S, Lambe, T

“…This is particularly evident for filoviruses, as there are multiple family members that can cause lethal haemorrhagic fever, including Zaire ebolavirus, Sudan ebolavirus, and Marburg virus. In an attempt to address this need, both pre-clinical and clinical studies previously used mixed or co-administered monovalent vaccines to prevent filovirus mediated disease. …”

FIFA World Cup 2022 and the Risk of Emergence of Zoonotic Diseases by Deepak Subedi, Saurav Pantha, Deepak Chandran, Madan Bhandari, Krishna Prasad Acharya, Kuldeep Dhama

“…Possible exotic diseases such as the Marburg virus disease could also be spread. Due to Qatar’s inexperience in hosting such major events, it is crucial to invest heavily in training for the early identification of infectious illnesses and the prevention of their spread among event attendees. …”
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A Comparative Analysis of Viral Richness and Viral Sharing in Cave-Roosting Bats by Anna R. Willoughby, Kendra L. Phelps, PREDICT Consortium, Kevin J. Olival

“…Cave-roosting bats are hosts to diverse viruses, some of which emerged in humans with severe consequences (e.g., severe acute respiratory syndrome coronavirus and Marburg virus). Characterizing patterns of viral richness and sharing among bat species are therefore important first steps for understanding bat-virus dynamics and mitigating future bat-human spillover. …”
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Monitoring Symptoms of Infectious Diseases: Perspectives for Printed Wearable Sensors by Ala’aldeen Al-Halhouli, Ahmed Albagdady, Ja’far Alawadi, Mahmoud Abu Abeeleh

“…The list includes COVID-19, Crimean-Congo Hemorrhagic Fever (CCHF), Ebola Virus Disease (EBOV), Marburg Virus Disease (MARV), Lassa Hemorrhagic Fever (LHF), Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS), Nipah Virus diseases (NiV), and Rift Valley fever (RVF). …”
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Developing Vaccines to Improve Preparedness for Filovirus Outbreaks: The Perspective of the USA Biomedical Advanced Research and Development Authority (BARDA) by Lindsay A. Parish, Eric J. Stavale, Christopher R. Houchens, Daniel N. Wolfe

“…Outbreaks of viral hemorrhagic fever caused by filoviruses have become more prevalent in recent years, with outbreaks of Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV) all occurring in 2022 and 2023. …”
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Toremifene interacts with and destabilizes the Ebola virus glycoprotein by Zhao, Y, Ren, J, Harlos, K, Jones, D, Zeltina, A, Bowden, T, Padilla-Parra, S, Fry, E, Stuart, D

“…Residues lining the binding site are highly conserved among filoviruses except Marburg virus (MARV), suggesting that MARV may not bind these drugs. …”

Toremifene interacts with and destabilizes the Ebola virus glycoprotein. by Zhao, Y, Ren, J, Harlos, K, Jones, D, Zeltina, A, Bowden, T, Padilla-Parra, S, Fry, E, Stuart, D

“…Residues lining the binding site are highly conserved amongst filoviruses except Marburg virus (MARV), suggesting that MARV may not bind these drugs. …”

Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus. by Chad E Mire, Joan B Geisbert, Andrea Marzi, Krystle N Agans, Heinz Feldmann, Thomas W Geisbert

“…In addition, a single injection of a blend of three rVSV vectors completely protected NHPs against challenge with SEBOV, ZEBOV, the former Côte d'Ivoire ebolavirus, and Marburg virus. However, recent studies suggest that complete protection against the newly discovered Bundibugyo ebolavirus (BEBOV) using several different heterologous filovirus vaccines is more difficult and presents a new challenge. …”
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Application of multiplex realtime PCR detection for hemorrhagic fever syndrome viruses by Yoonhyuk Choi, Younghee Kim

“…Results: Six kinds of viruses, including Crimean-Congo hemorrhagic fever virus, Omsk hemorrhagic fever virus, Sabia virus, Chapare virus, Yellow fever virus, and Variola virus (A4L gene, B12R gene), were able to confirm the detection limit of 0.5 copies/μl, and other Ebola virus, Marburg virus, Rift Valley fever virus, Kyasanur Forest disease virus, Junin virus, Guanarito virus, Machupo virus, Chikungunya virus, Hantavirus, Dengue virus types 1–4, and Lassa virus (L gene, GPC gene), and 11 kinds of viruses, the detection limit was confirmed at 5 copies/μl. …”
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Vaccine Licensure in the Absence of Human Efficacy Data by Courtney L. Finch, Christian Martinez, Elizabeth Leffel, Mario H. Skiadopoulos, Adam Hacker, Betty Mwesigwa, Diadié Maïga, Ian Mugisa, Grant Munkwase, Roxana Rustomjee

“…Given the urgent unmet need for new Marburg virus and Ebola Sudan virus vaccines, the Sabin Vaccine Institute hosted a key stakeholder virtual meeting in May 2021 to explore the possibility of licensure by use of an “animal rule-like” licensure process, based on a risk/benefit assessment specific to regional needs and informed by epidemiology. …”
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Coronaviruses of synantropic bats: an unexplored threat by Lipilkina Tatyana, Popov Ilia, Kitsenko Karina, Popov Igor, Ermakov Alexey

“…And are associated with the spread of various viruses (Marburg virus, Ebola virus) and, above all, coronaviruses. …”
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Mapping the global distribution of zoonoses of public health importance by Pigott, D

“…Chapter 5 investigates Marburg virus disease and considers the variety of different factors relating to all aspects of the transmission cycle that must be considered in these analyses. …”

A prophylactic multivalent vaccine against different filovirus species is immunogenic and provides protection from lethal infections with Ebolavirus and Marburgvirus species in non... by Benoit Callendret, Jort Vellinga, Kerstin Wunderlich, Ariane Rodriguez, Robin Steigerwald, Ulrike Dirmeier, Cedric Cheminay, Ariane Volkmann, Trevor Brasel, Ricardo Carrion, Luis D Giavedoni, Jean L Patterson, Chad E Mire, Thomas W Geisbert, Jay W Hooper, Mo Weijtens, Jutta Hartkoorn-Pasma, Jerome Custers, Maria Grazia Pau, Hanneke Schuitemaker, Roland Zahn

“…We investigated the immunogenicity and protection elicited by multivalent vaccines expressing glycoproteins (GP) from Ebola virus (EBOV), Sudan virus (SUDV), Taï Forest virus (TAFV) and Marburg virus (MARV). Immune responses against filovirus GP have been associated with protection from disease. …”
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Predicting the combined effects of case isolation, safe funeral practices, and contact tracing during Ebola virus disease outbreaks. by Aliou Bouba, Kristina Barbara Helle, Kristan Alexander Schneider

“…<h4>Background</h4>The recent outbreaks of Ebola virus disease (EVD) in Uganda and the Marburg virus disease (MVD) in Ghana reflect a persisting threat of Filoviridae to the global health community. …”
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Immunoinformatic and reverse vaccinology-based designing of potent multi-epitope vaccine against Marburgvirus targeting the glycoprotein by Hassan Yousaf, Anam Naz, Naila Zaman, Mubashir Hassan, Ayesha Obaid, Faryal Mehwish Awan, Syed Sikander Azam

“…Marburg virus (MARV) has been a major concern since its first outbreak in 1967. …”
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CRISPR-based biosensor for the detection of Marburg and Ebola virus by Irkham Irkham, Abdullahi Umar Ibrahim, Pwadubashiyi Coston Pwavodi, Chidi Wilson Nwekwo, Yeni Wahyuni Hartati

“…Marburg Virus is one of the most neglected diseases that dated back to 1967. …”
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