Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM by Tobias Raisch, Andreas Brockmann, Ulrich Ebbinghaus-Kintscher, Jörg Freigang, Oliver Gutbrod, Jan Kubicek, Barbara Maertens, Oliver Hofnagel, Stefan Raunser

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A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins by Katja Gotthardt, Mandy Lokaj, Carolin Koerner, Nathalie Falk, Andreas Gießl, Alfred Wittinghofer

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Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation by Dorota Rousová, Vaishnavi Nivsarkar, Veronika Altmannova, Vivek B Raina, Saskia K Funk, David Liedtke, Petra Janning, Franziska Müller, Heidi Reichle, Gerben Vader, John R Weir

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The mother of all actins? by Felipe Merino, Stefan Raunser

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Profilin and formin constitute a pacemaker system for robust actin filament growth by Johanna Funk, Felipe Merino, Larisa Venkova, Lina Heydenreich, Jan Kierfeld, Pablo Vargas, Stefan Raunser, Matthieu Piel, Peter Bieling

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Structural basis for tRNA-dependent cysteine biosynthesis by Meirong Chen, Koji Kato, Yume Kubo, Yoshikazu Tanaka, Yuchen Liu, Feng Long, William B. Whitman, Pascal Lill, Christos Gatsogiannis, Stefan Raunser, Nobutaka Shimizu, Akira Shinoda, Akiyoshi Nakamura, Isao Tanaka, Min Yao

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Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol by Jan-Erik Hoffmann, Yessica Fermin, Ruth LO Stricker, Katja Ickstadt, Eli Zamir

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Organization at criticality enables processing of time‐varying signals by receptor networks by Angel Stanoev, Akhilesh P Nandan, Aneta Koseska

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Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors by Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias P Müller, Daniel Rauh

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HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment by Hiroaki Tachiwana, Sebastian Müller, Julia Blümer, Kerstin Klare, Andrea Musacchio, Geneviève Almouzni

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Cryo-EM reveals the asymmetric assembly of squid hemocyanin by Yoshikazu Tanaka, Sanae Kato, Markus Stabrin, Stefan Raunser, Takashi Matsui, Christos Gatsogiannis

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Interaction of RSC Chromatin Remodeling Complex with Nucleosomes Is Modulated by H3 K14 Acetylation and H2B SUMOylation In Vivo by Neha Jain, Davide Tamborrini, Brian Evans, Shereen Chaudhry, Bryan J. Wilkins, Heinz Neumann

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Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling by Pim J Huis in 't Veld, Vladimir A Volkov, Isabelle D Stender, Andrea Musacchio, Marileen Dogterom

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Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins by Aimin Yang, Supansa Pantoom, Yao-Wen Wu

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Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1–Ccz1 by Stephan Kiontke, Lars Langemeyer, Anne Kuhlee, Saskia Schuback, Stefan Raunser, Christian Ungermann, Daniel Kümmel

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Optogenetic Tuning Reveals Rho Amplification-Dependent Dynamics of a Cell Contraction Signal Network by Dominic Kamps, Johannes Koch, Victor O. Juma, Eduard Campillo-Funollet, Melanie Graessl, Soumya Banerjee, Tomáš Mazel, Xi Chen, Yao-Wen Wu, Stephanie Portet, Anotida Madzvamuse, Perihan Nalbant, Leif Dehmelt

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Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2 by Erica Di Cesare, Sara Moroni, Jessica Bartoli, Michela Damizia, Maria Giubettini, Carolin Koerner, Veronica Krenn, Andrea Musacchio, Patrizia Lavia

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Molecular architecture of black widow spider neurotoxins by Minghao Chen, Daniel Blum, Lena Engelhard, Stefan Raunser, Richard Wagner, Christos Gatsogiannis

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The Aurora B kinase in chromosome biorientation and spindle checkpoint signalling by Veronica eKrenn, Veronica eKrenn, Andrea eMusacchio, Andrea eMusacchio

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Methodology-driven efficient synthesis of cytotoxic (±)-piperarborenine B by Chunngai Hui, Andrey P. Antonchick

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