A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN by Abdelghani Mazouzi, Alexey Stukalov, André C. Müller, Doris Chen, Marc Wiedner, Jana Prochazkova, Shih-Chieh Chiang, Michael Schuster, Florian P. Breitwieser, Andreas Pichlmair, Sherif F. El-Khamisy, Christoph Bock, Robert Kralovics, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou

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Predicting sepsis using deep learning across international sites: a retrospective development and validation studyResearch in context by Michael Moor, Nicolas Bennett, Drago Plečko, Max Horn, Bastian Rieck, Nicolai Meinshausen, Peter Bühlmann, Karsten Borgwardt

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M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion by Yi Luo, Lijian Shao, Jianhui Chang, Wei Feng, Y. Lucy Liu, Michele H. Cottler-Fox, Peter D. Emanuel, Martin Hauer-Jensen, Irwin D. Bernstein, Lingbo Liu, Xing Chen, Jianfeng Zhou, Peter J. Murray, Daohong Zhou

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Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbid... by Orsolya Genzel-Boroviczeny, Matthias Mann, Susanne Pangratz-Fuehrer, Robin Eisenburger, Janne Scharpenack, Philipp E Geyer, Johannes B Müller-Reif, Nadja van Hagen, Alina M Müller, Majken Karoline Jensen, Christoph Klein, Claudia Nussbaum, Wolfgang Bodensohn

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Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding by Manuel Alonso Y Adell, Simona M Migliano, Srigokul Upadhyayula, Yury S Bykov, Simon Sprenger, Mehrshad Pakdel, Georg F Vogel, Gloria Jih, Wesley Skillern, Reza Behrouzi, Markus Babst, Oliver Schmidt, Michael W Hess, John AG Briggs, Tomas Kirchhausen, David Teis

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COVID-19 Genomic Surveillance in Bangui (Central African Republic) Reveals a Landscape of Circulating Variants Linked to Validated Antiviral Targets of SARS-CoV-2 Proteome by Ulrich Vickos, Marianna Camasta, Nicole Grandi, Sante Scognamiglio, Tobias Schindler, Marie Roseline Darnycka Belizaire, Ernest Lango-Yaya, Giscard Wilfried Koyaweda, Oscar Senzongo, Simon Pounguinza, Kaleb Kandou Jephté Francis Estimé, Stephanie N’yetobouko, Christelle Luce Bobossi Gadia, Dominos-Alfred Feiganazoui, Alain Le Faou, Massimiliano Orsini, Carlo Federico Perno, Luca Zinzula, Clotaire Donatien Rafaï

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Linking the impact of aging on visual short-term memory capacity with changes in the structural connectivity of posterior thalamus to occipital cortices by Aurore Menegaux, Felix J.B. Bäuerlein, Aliki Vania, Natan Napiorkowski, Julia Neitzel, Adriana L. Ruiz-Rizzo, Hermann J. Müller, Christian Sorg, Kathrin Finke

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Aggrecan governs intervertebral discs development by providing critical mechanical cues of the extracellular matrix by Marta Empere, Marta Empere, Xujia Wang, Carina Prein, Carina Prein, Anders Aspberg, Markus Moser, Markus Moser, Toshitaka Oohashi, Hauke Clausen-Schaumann, Attila Aszodi, Attila Aszodi, Paolo Alberton, Paolo Alberton

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Risk willingness in multiple system atrophy and Parkinson’s disease understanding patient preferences by Alexander Maximilian Bernhardt, Marc Oeller, Isabel Friedrich, Emre Kocakavuk, Eliana Nachman, Kevin Peikert, Malte Roderigo, Andreas Rossmann, Tabea Schröter, Lea Olivia Wilhelm, Tino Prell, Christoph van Riesen, Johanna Nieweler, Sabrina Katzdobler, Markus Weiler, Heike Jacobi, Tobias Warnecke, Inga Claus, Carla Palleis, Stephan Breimann, Björn Falkenburger, Moritz Brandt, Andreas Hermann, Jost-Julian Rumpf, Joseph Claßen, Günter Höglinger, Florin Gandor, Johannes Levin, Armin Giese, Annette Janzen, Wolfgang Hermann Oertel

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A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis by Dale Archer, María Elisa Pérez-Muñoz, Stephanie Tollenaar, Simona Veniamin, Naomi Hotte, Christopher C. Cheng, Kristoff Nieves, Jee-Hwan Oh, Lilian Morceli, Susan Muncner, Daniel R. Barreda, Gurumoorthy Krishnamoorthy, Christopher Power, Jan-Peter van Pijkeren, Jens Walter

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Case report: Immunovirotherapy as a novel add-on treatment in a patient with thoracic NUT carcinoma by Linus D. Kloker, Branko Calukovic, Katrin Benzler, Alexander Golf, Sebastian Böhm, Sven Günther, Marius Horger, Simone Haas, Simone Haas, Susanne Berchtold, Julia Beil, Julia Beil, Mary E. Carter, Tina Ganzenmueller, Stephan Singer, Abbas Agaimy, Robert Stöhr, Arndt Hartmann, Thomas Duell, Sandra Mairhofer, Fabian Fohrer, Niels Reinmuth, Lars Zender, Lars Zender, Ulrich M. Lauer, Ulrich M. Lauer

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Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways by Spencer Hill, Kurt Reichermeier, Daniel C Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moradian, Michael J Sweredoski, Nora Caberoy, Brenda A Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger

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Inactivated tick-borne encephalitis vaccine elicits several overlapping waves of T cell response by Anastasiia L. Sycheva, Ekaterina A. Komech, Ekaterina A. Komech, Mikhail V. Pogorelyy, Anastasia A. Minervina, Shamil Z. Urazbakhtin, Maria A. Salnikova, Maria A. Salnikova, Mikhail F. Vorovitch, Mikhail F. Vorovitch, Eugene P. Kopantzev, Ivan V. Zvyagin, Ivan V. Zvyagin, Alexander Y. Komkov, Alexander Y. Komkov, Ilgar Z. Mamedov, Yuri B. Lebedev, Yuri B. Lebedev

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Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition by Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Cyrus Khandanpour, Cyrus Khandanpour

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STAT3β is a tumor suppressor in acute myeloid leukemia by Petra Aigner, Tatsuaki Mizutani, Jaqueline Horvath, Thomas Eder, Stefan Heber, Karin Lind, Valentin Just, Herwig P. Moll, Assa Yeroslaviz, Michael J.M. Fischer, Lukas Kenner, Balázs Győrffy, Heinz Sill, Florian Grebien, Richard Moriggl, Emilio Casanova, Dagmar Stoiber

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Macrophages inhibit Coxiella burnetii by the ACOD1‐itaconate pathway for containment of Q fever by Lisa Kohl, Md Nur A Alam Siddique, Barbara Bodendorfer, Raffaela Berger, Annica Preikschat, Christoph Daniel, Martha Ölke, Elisabeth Liebler‐Tenorio, Jan Schulze‐Luehrmann, Michael Mauermeir, Kai‐Ting Yang, Inaya Hayek, Manuela Szperlinski, Jennifer Andrack, Ulrike Schleicher, Aline Bozec, Gerhard Krönke, Peter J Murray, Stefan Wirtz, Masahiro Yamamoto, Valentin Schatz, Jonathan Jantsch, Peter Oefner, Daniel Degrandi, Klaus Pfeffer, Katja Mertens‐Scholz, Simon Rauber, Christian Bogdan, Katja Dettmer, Anja Lührmann, Roland Lang

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Calcium-mediated actin reset (CaAR) mediates acute cell adaptations by Pauline Wales, Christian E Schuberth, Roland Aufschnaiter, Johannes Fels, Ireth García-Aguilar, Annette Janning, Christopher P Dlugos, Marco Schäfer-Herte, Christoph Klingner, Mike Wälte, Julian Kuhlmann, Ekaterina Menis, Laura Hockaday Kang, Kerstin C Maier, Wenya Hou, Antonella Russo, Henry N Higgs, Hermann Pavenstädt, Thomas Vogl, Johannes Roth, Britta Qualmann, Michael M Kessels, Dietmar E Martin, Bela Mulder, Roland Wedlich-Söldner

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MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells by Torben Gehring, Tabea Erdmann, Marco Rahm, Carina Graß, Andrew Flatley, Thomas J. O’Neill, Simone Woods, Isabel Meininger, Ozge Karayel, Kerstin Kutzner, Michael Grau, Hisaaki Shinohara, Katja Lammens, Regina Feederle, Stefanie M. Hauck, Georg Lenz, Daniel Krappmann

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Multi-targeted therapy resistance via drug-induced secretome fucosylation by Mark Borris D Aldonza, Junghwa Cha, Insung Yong, Jayoung Ku, Pavel Sinitcyn, Dabin Lee, Ryeong-Eun Cho, Roben D Delos Reyes, Dongwook Kim, Soyeon Kim, Minjeong Kang, Yongsuk Ku, Geonho Park, Hye-Jin Sung, Han Suk Ryu, Sukki Cho, Tae Min Kim, Pilnam Kim, Je-Yoel Cho, Yoosik Kim

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A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases by Alexander M. Bernhardt, Steffen Tiedt, Daniel Teupser, Martin Dichgans, Bernhard Meyer, Jens Gempt, Peer-Hendrik Kuhn, Mikael Simons, Carla Palleis, Endy Weidinger, Georg Nübling, Lesca Holdt, Lisa Hönikl, Christiane Gasperi, Pieter Giesbertz, Stephan A. Müller, Stephan Breimann, Stefan F. Lichtenthaler, Bernhard Kuster, Matthias Mann, Axel Imhof, Teresa Barth, Stefanie M. Hauck, Henrik Zetterberg, Markus Otto, Wilko Weichert, Bernhard Hemmer, Johannes Levin

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