Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation by Shuai Qiao, Chia-Wei Lee, Dawafuti Sherpa, Jakub Chrustowicz, Jingdong Cheng, Maximilian Duennebacke, Barbara Steigenberger, Ozge Karayel, Duc Tung Vu, Susanne von Gronau, Matthias Mann, Florian Wilfling, Brenda A. Schulman

Get full text

In situ cryo-electron tomography reveals gradient organization of ribosome biogenesis in intact nucleoli by Philipp S. Erdmann, Zhen Hou, Sven Klumpe, Sagar Khavnekar, Florian Beck, Florian Wilfling, Jürgen M. Plitzko, Wolfgang Baumeister

Get full text

The MinDE system is a generic spatial cue for membrane protein distribution in vitro by Beatrice Ramm, Philipp Glock, Jonas Mücksch, Philipp Blumhardt, Daniela A. García-Soriano, Michael Heymann, Petra Schwille

Get full text

Membrane association and remodeling by intraflagellar transport protein IFT172 by Qianmin Wang, Michael Taschner, Kristina A. Ganzinger, Charlotte Kelley, Alethia Villasenor, Michael Heymann, Petra Schwille, Esben Lorentzen, Naoko Mizuno

Get full text

AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics by Wen-Feng Zeng, Xie-Xuan Zhou, Sander Willems, Constantin Ammar, Maria Wahle, Isabell Bludau, Eugenia Voytik, Maximillian T. Strauss, Matthias Mann

Get full text

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system by Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman Körner, Hauke Holthusen, Victoria A. Trinkaus, Irina Dudanova, Rubén Fernández-Busnadiego, Wolfgang Baumeister, David W. Sanders, Saurabh Gautam, Marc I. Diamond, F. Ulrich Hartl, Mark S. Hipp

Get full text

In situ architecture of neuronal α-Synuclein inclusions by Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, Felix J. B. Bäuerlein, Qiang Guo, Thomas Arzberger, Wolfgang Baumeister, Irina Dudanova, Mark S. Hipp, F. Ulrich Hartl, Rubén Fernández-Busnadiego

Get full text

Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel by Marvin Thielert, Ericka CM Itang, Constantin Ammar, Florian A Rosenberger, Isabell Bludau, Lisa Schweizer, Thierry M Nordmann, Patricia Skowronek, Maria Wahle, Wen‐Feng Zeng, Xie‐Xuan Zhou, Andreas‐David Brunner, Sabrina Richter, Mitchell P Levesque, Fabian J Theis, Martin Steger, Matthias Mann

Get full text

The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model by Patricia Yuste-Checa, Victoria A. Trinkaus, Irene Riera-Tur, Rahmi Imamoglu, Theresa F. Schaller, Huping Wang, Irina Dudanova, Mark S. Hipp, Andreas Bracher, F. Ulrich Hartl

Get full text

Dissecting the molecular organization of the translocon-associated protein complex by Stefan Pfeffer, Johanna Dudek, Miroslava Schaffer, Bobby G. Ng, Sahradha Albert, Jürgen M. Plitzko, Wolfgang Baumeister, Richard Zimmermann, Hudson H. Freeze, Benjamin D. Engel, Friedrich Förster

Get full text

Reconstitution of contractile actomyosin rings in vesicles by Thomas Litschel, Charlotte F. Kelley, Danielle Holz, Maral Adeli Koudehi, Sven K. Vogel, Laura Burbaum, Naoko Mizuno, Dimitrios Vavylonis, Petra Schwille

Get full text

AlphaPept: a modern and open framework for MS-based proteomics by Maximilian T. Strauss, Isabell Bludau, Wen-Feng Zeng, Eugenia Voytik, Constantin Ammar, Julia P. Schessner, Rajesh Ilango, Michelle Gill, Florian Meier, Sander Willems, Matthias Mann

Get full text

Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions by Karl-Uwe Reusswig, Julia Bittmann, Martina Peritore, Mathilde Courtes, Benjamin Pardo, Michael Wierer, Matthias Mann, Boris Pfander

Get full text

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin by Marina Theodosiou, Moritz Widmaier, Ralph T Böttcher, Emanuel Rognoni, Maik Veelders, Mitasha Bharadwaj, Armin Lambacher, Katharina Austen, Daniel J Müller, Roy Zent, Reinhard Fässler

Get full text

Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation by Dawafuti Sherpa, Judith Mueller, Özge Karayel, Peng Xu, Yu Yao, Jakub Chrustowicz, Karthik V Gottemukkala, Christine Baumann, Annette Gross, Oliver Czarnecki, Wei Zhang, Jun Gu, Johan Nilvebrant, Sachdev S Sidhu, Peter J Murray, Matthias Mann, Mitchell J Weiss, Brenda A Schulman, Arno F Alpi

Get full text

Identification of covalent modifications regulating immune signaling complex composition and phenotype by Annika Frauenstein, Stefan Ebner, Fynn M Hansen, Ankit Sinha, Kshiti Phulphagar, Kirby Swatek, Daniel Hornburg, Matthias Mann, Felix Meissner

Get full text

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE by J. Josephine Botsch, Roswitha Junker, Michèle Sorgenfrei, Patricia P. Ogger, Luca Stier, Susanne von Gronau, Peter J. Murray, Markus A. Seeger, Brenda A. Schulman, Bastian Bräuning

Get full text

Distinct and evolutionary conserved structural features of the human nuclear exosome complex by Piotr Gerlach, Jan M Schuller, Fabien Bonneau, Jérôme Basquin, Peter Reichelt, Sebastian Falk, Elena Conti

Get full text

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling by Kirti Sharma, Rochelle C.J. D’Souza, Stefka Tyanova, Christoph Schaab, Jacek R. Wiśniewski, Jürgen Cox, Matthias Mann

Get full text

Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis by Kshiti Phulphagar, Lars I. Kühn, Stefan Ebner, Annika Frauenstein, Jonathan J. Swietlik, Jan Rieckmann, Felix Meissner

Get full text