Effective type label-based synergistic representation learning for biomedical event trigger detection by Hao, Anran, Yuan, Haohan, Hui, Siu Cheung, Su, Jian

“…However, they lack effective mechanisms to obtain semantic clues from label specification and sentence context. …”
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Nodal reliability and nodal price in deregulated power markets by Yi, Ding

“…Economic segregation and service unbundling have changed the mechanism of conventional system planning and operations. …”
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Molecular study of Rasd1 transcriptional regulation and Rasd1-NonO interaction. by Ong, Angeline Shufen.

“…These findings reveal a novel mechanism by which the coregulator activity of NonO can be modulated.…”
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Synthesis of crystalline chalcogenide arsenates in surfactants via a low temperature route by Eashwer Umesh Athresh

“…The discovery of new materials is important not just from the standpoint of new applications, but is also important for the study of the fundamental forces that guide the reaction mechanism. Ever since Flanigen et. al. first reported the synthesis of zeolite like open framework in 1982, this field has grown exponentially. …”
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Impact resistance of reinforced concrete members by Low, Kun Sheng

“…However, lightweight concrete was observed to have better energy dissipation mechanisms which reduce their flexural deformation. …”
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Conformational ensemble modeling of multi-domain proteins with experimental data by Zhu, Guanhua

“…Their structure determination is crucial for understanding the mechanism of their interactions and functions, but it remains a challenge to derive the structure ensemble of flexible biomolecules solely from experimental data. …”
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Extended thermophilic digestion enhances hydrolysis and methane production in subsequent second stage mesophilic digestion by Chua, Xin Yi

“…Instead, these results suggested that a shorter thermophilic anaerobic digester is more preferred as a pre-treatment mechanism.…”
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The role of membrane curvature in nanoscale topography-induced intracellular signaling by Lou, Hsin-Ya, Zhao, Wenting, Zeng, Yongpeng, Cui, Bianxiao

“…In this Account, we focus on some recent studies that support a new mechanism that local membrane curvature induced by nanoscale topography directly acts as a biochemical signal to induce intracellular signaling, which we refer to as the curvature hypothesis. …”
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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…While many patients regain olfactory function within weeks, a significant portion experience persistent anosmia lasting over a year post-infection. The underlying mechanisms responsible for this sensory deficit remain largely uncharacterized. …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…Combining a JAK2 inhibitor with an interferon may be synergistic, as haematopoietic cells are activated from quiescence (a typical kinase resistance mechanism) rendering them more sensitive to inhibition. …”

The influence of polarisation on the behaviour of anions within ion channels and nanopores by Phan, LX

“…Whilst cation channels have been studied in great depth, general mechanisms underlying anion selectivity and permeation within such pores remain unclear. …”

The critical role of IL-23 receptor positive T cells in the pathogenesis of anterior uveitis associated with spondyloarthropathy by Hedley, R

“…I achieve this in vivo in mice through a novel mechanism enabling the sustained localized overexpression of IL-23 in the inner eye by adeno-associated virus gene transfer. …”

Methodology development and synthesis of a biologically relevant natural product and targeted scaffold discovery for serine hydrolase inhibition by Kornahrens, A

“…</p> <p>The natural product streptonigrin, a potent antitumor antibiotic, showed promise in clinical trials ultimately terminated in the 1970s. The underexplored mechanism of action prompted a reexamination of this potential therapeutic. …”

The role of dendritic cells in determining the breadth and epitope specificity of the initial CD8+ T cell response during acute HIV-1 infection by Partridge, T

“…In this thesis, the hypotheses that prevalent presentation of Nef-derived epitopes by dendritic cells (DCs) favours priming of Nef-biased CD8⁺ T cell responses in AHI, and that impairments in DC function after the first responses are primed delay expansion of responses of additional specificities, were explored. Mechanisms of impairment of DC function in AHI were not definitely identified, although preexposure of monocyte-derived DCs to IFN&amp;alpa;, which is rapidly induced during AHI, was shown to reduce TLR3-induced co-stimulatory molecule expression and affect the quality of the CD8+ T cell response primed <em>in vitro</em>. …”

Perceiving agency in a multi-agent context: more interactions with the environment yet reduced agency in depression by Jain, R

“…</p> <p>These findings provide valuable insights into agency perception mechanisms, with potential implications for informing interventions. …”

Direct measurement of magnetic monopole charge and transport dynamics by Hsu, C

“…This thesis endeavors to elucidate the dynamics of the monopole fluid by developing advanced SQUID-based spectrometer and provides several unique pieces of evidence towards the dynamical mechanism.</p> <p>In Chapter 1 of the thesis. I first briefly introduce spin ice materials and the emergence of the magnetic monopoles from a historical basis. …”

Key transcriptional regulators of neutrophil function in inflammation by Ai, Z

“…However, the molecular mechanisms underlining neutrophil function during inflammation have yet to be fully elucidated. …”

Association between a selective 5-HT4 receptor agonist and incidence of major depressive disorder: emulated target trial by de Cates, AN, Harmer, CJ, Harrison, PJ, Cowen, PJ, Emmanuel, A, Travis, S, Murphy, SE, Taquet, M

“…<p><b>Method</b></p> Using anonymised routinely collected data from a large-scale USA electronic health records network, we conducted an emulated target trial comparing depression incidence over 1 year in individuals without prior diagnoses of major mental illness, who initiated treatment with prucalopride versus two alternative anti-constipation agents that act by different mechanisms (linaclotide and lubiprostone). Cohorts were matched for 121 covariates capturing sociodemographic factors, and historical and/or concurrent comorbidities and medications. …”

Paradoxical choice and the value of information in animals by Ajuwon, V

“…</p> <br> <p>In Chapter 1, I use three variations of the paradoxical choice protocol in rats to investigate the psychological mechanisms underlying information-seeking behaviour. …”

DEWP: deep expansion learning for wind power forecasting by Fan, W, Fu, Y, Zheng, S, Bian, J, Zhou, Y, Xiong, H

“…DEWP starts with a stack-by-stack architecture, where each stack is composed of (i) a&nbsp;<em>variable expansion block</em>&nbsp;that makes use of convolutional layers to capture dependencies among multiple variables; (ii) a&nbsp;<em>time expansion block</em>&nbsp;that applies Fourier series and backcast/forecast mechanism to learn temporal dependencies in sequential patterns. …”