Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore by Mina, Theresia, Xie, Wubin, Low, Dorrain Yanwen, Wang, Xiaoyan, Lam, Benjamin Chih Chiang, Sadhu, Nilanjana, Ng, Hong Kiat, Nur-Azizah Aziz, Tong, Terry Yoke Yin, Kerk, Swat Kim, Choo, Wee Lin, Low, Guo Liang, Halimah Ibrahim, Lim, Liming, Tai, E Shyong, Wansaicheong, Gervais, Dalan, Rinkoo, Yew, Yik Weng, Elliott, Paul, Riboli, Elio, Loh, Marie, Ngeow, Joanne, Lee, Eng Sing, Lee, Jimmy, Best, James, Chambers, John

“…However, the variation in insulin resistance and type 2 diabetes risk between Asian subgroups is not consistently explained by adiposity, indicating an important role for additional mechanisms underlying the susceptibility to cardiometabolic disease in Asian populations.…”
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Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…However, its antitumor efficacy is limited when used alone due to compensatory energy mechanisms. Hence, we introduced glycolysis inhibitor 2-deoxy-d-glucose (2-DG) to inhibit an alternative tumor energy pathway. …”
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Studies on high-frequency noise characteristics in deep submicron NMOSFETs by Zeng, Rong

“…The results show a strong dependence of degradation of noise parameters on the gate leakage. The degradation mechanisms are analyzed by extraction of the channel and gate noise using a noise equivalent circuit model. …”
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An investigation on correlation between linguistic features and personality traits : a case of Singapore Twitter users. by Yew, Chee Soon.

“…Third, the lack of a reviewing mechanism decreased the reliability of the results as well.. …”
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Performance monitoring for quantum key distribution systems by Yu, Timothy Shengrong

“…Unlike conventional cryptography, quantum key distribution’s security is governed by the laws of quantum mechanics. The basic principle of quantum key distribution is to encode classical binary bit information onto the properties of quantum states such as the polarisation of a photon. …”
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g-C3N4/ZnO hybrid material as photocatalyst for photocatalytic CO2 reduction by Hu, Zhaoning

“…Further study could concentrate on exploring the detailed mechanism in g-C3N4 synthesizing process, finding the optimal amount of g-C3N4 in the hybrid material and trying alternative g-C3N4 synthesizing method to grow g-C3N4 on other ZnO morphologies to get better photocatalytic CO2 reduction performance.…”
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Three essays on corporate finance by Sun, Rui

“…To find out what is the driving force of private firms’ cash flow allocation, we attempt to draw parallel evidence from public firms, but find that the analysis within public firms cannot be applied mechanically to private firms. Special features of private firms – more concentrated equity ownership, more powerful shareholders with a strong desire for liquidity and diversification, and higher agency costs associated with debt finance are very likely to play a vital role in shaping their cash flow allocation. …”
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The road to federalism : finding the middle ground in Nepal, Myanmar and Sri Lanka by Breen, Michael Gerard

“…I show how the initial nation-building mechanism, as a tool of power reproduction by the dominant ethnic group, kick started a simultaneous reactive sequence leading to centralization, concession and ultimately, a federal compromise. …”
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Controlled self-assembly of Ni foam supported poly(ethyleneimine)/reduced graphene oxide three-dimensional composite electrodes with remarkable synergistic effects for efficient ox... by Zhao, Ming, Yuan, Weiyong, Li, Chang Ming

“…It also provides scientific insight into the mechanism for the superior and tunable OER catalytic activity, which is critical for further improving the OER catalytic performance.…”
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The future of nuclear power in India: a question of liability law by Sengupta, A

“…</p> <p>The Act, which sets up a specialized compensation mechanism for victims of nuclear incidents, contains provisions arguably inconsistent with India’s international obligations. …”

Viral and immune dynamics of genital human papillomavirus infections in young women with high temporal resolution by Tessandier, N, Elie, B, Boué, V, Selinger, C, Rahmoun, M, Bernat, C, Grasset, S, Groc, S, Bedin, A, Beneteau, T, Bonneau, M, Graf, C, Jacobs, N, Kamiya, T, Kerioui, M, Lajoie, J, Melki, I, Prétet, J, Reyné, B, Schlecht-Louf, G, Sofonea, MT, Supplisson, O, Wymant, C, Foulongne, V

“…Most anogenital HPV infections are cleared in less than two years, but the underlying mechanisms that favour persistence in around 10% of women remain largely unknown. …”

Optimising the surveillance and control of communicable diseases: the effects of population heterogeneity on early outbreak transmission dynamics by Lovell-Read, F

“…In this thesis, we focus on modelling transmission dynamics in the very early stages of an infectious disease outbreak, using mathematical and computational techniques to design control mechanisms that facilitate early case detection and local containment.…”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…LGI1 autoantibodies are known to interfere with presynaptic function and neuronal excitability; however, their epitope-specific mechanisms are incompletely understood.</p> <br> <p><strong>Methods:</strong> We used patient-derived monoclonal autoantibodies (mAbs), which target either LRR or EPTP domains of LGI1 to investigate long-term antibody-induced alteration of neuronal function. …”

Influence of the exchange symmetry beyond the exclusion principle by Tennie, F

“…So far, nothing is known about its origin and mechanisms. We will close this gap by analytically examining the dependence of quasipinning on the particle number, the dimensionality and the spin polarisation in a representative physical model system. …”

Pilot study of a ketogenic diet in bipolar disorder: a process evaluation by P. Rigby, B, Needham, N, Grossi, H, Kamenska, I, H. Campbell, I, Meadowcroft, B, Creasy, F, Fisher, C, Bahuguna, P, Norrie, J, Thompson, G, C. Gibbs, M, Mitchell-Grigorjeva, M, McLellan, A, Moses, T, Burgess, K, Brown, R, J. Thrippleton, M, Campbell, H, J. Smith, D, A. Simpson, S

“…Results: Five themes were identified in the qualitative data: (1) ‘Encouraging entry and supporting exit’ (e.g. recognising and managing participants’ varied motives and expectations, including around weight loss and symptom alleviation); (2) ‘Challenging but potentially transformational,’ which reflects that while it can be difficult to initiate and maintain a ketogenic diet day-to-day, many participants perceived physical and psychological benefits (e.g. significant weight loss, mood stability and enhanced ability to focus); (3) ‘Intervention facilitators,’ including a range of behavioural (e.g. goal setting), social (e.g. family and dietitians) and technological (e.g. apps for monitoring) support mechanisms; (4) ‘Intervention barriers’ (e.g. dietary preferences, concerns about the diet and its impact, the testing burden and capacity of the delivery team); and (5) ‘The wider context’ (e.g. the cost of living and sociocultural expectations) was a crucial factor explaining differential experiences. …”

The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…In many mammals, a large proportion of the calcium responsible for activation of the contractile apparatus is released from the sarcoplasmic reticulum (SR), and this release is regulated via many mechanisms.</p> <p>One regulatory factor that has earned much attention in recent years is Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and its probable receptor, Two-Pore Channel-2 (TPC2), which is found on the surface of lysosomes. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…Hence, hepatic insulin action provides an important layer of regulation in the maintenance of whole-body metabolic homeostasis, and its dysregulation is closely associated with metabolic disease progression. Importantly, the mechanisms underlying hepatic insulin signalling are still not completely understood.…”

Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Amboko, B, Nzinga, J, Tsofa, B, Mugo, P, Musiega, A, Maritim, B, Wong, E, Mazzilli, C, Ng’ang’a, W, Hagedorn, B, Turner, G, Musuva, A, Murira, F, Ravishankar, N, Hussein, S, Barasa, E

“…The process evaluation will assess the emergence of PCN reforms, the implementation experience, the mechanism of impact and how the context affects implementation and outcomes. …”

Investigating the functional and metabolic role of carnitine in the diabetic heart using hyperpolarized MRI by Savic, D

“…This work has shown the potential for using hyperpolarized and CINE MRI in better understanding the mechanism of L-carnitine’s effect on the diabetic heart, and it may provide new insights into novel therapeutics.…”

Synthetic post-translational protein modification as a switch for activity by Faulkner, SC

“…A model was suggested in which the H3K36 side chain is normally sequestered in intact nucleosomes in a hydrogen bonding interaction with the phosphate of the DNA backbone, and the interaction entirely abrogated only when the third methyl group is added to form H3K36me3, providing a ‘methyl- switch’ mechanism for context-dependent reader selectivity. …”