Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells by Pluta, AJ

“…The elucidation of the molecular mechanisms behind CDK1 regulation of these transcription factors will surely remain an intriguing avenue of research.…”

Mitogenic activity of mesenchymal stem cells on hematopoietic stem cells via cellular analysis and gene expression by Mohadeseh, Hashem Boroojerdi

“…Conclusion: The present study support the notion that the human umbilical cord derived MSC as potential feeder cells that could preserve and amplify the number of human cord blood derived-HSC. The cellular mechanisms that govern this expansion of HSC could be resulted from the protective activity exerted by MSC via reducing apoptosis whilst activating cell cycle. …”
Get full text

Ergogenic and metabolites analyses of piyarom date (Phoenix dactylifera L.) using NMR-based metabolomics and its effect on Sprague dawley rats by Shanan, Hana Kadum

“…Based on the metabolite identify a clear understanding regarding the underlying mechanism of ergogenic effect of Piyarom date fruit can be elucidation. …”
Get full text

Developing a Household Flood Vulnerability Index for Managing the Risk of Flood Disasters (S/O 13584) by Hassan, Sallahuddin, Abu Bakar, Arpah, Othman, Zalila, Khalid, Mohamad Sukeri, Abu Talib, Mansor

“…Also, evacuation routes, coping mechanisms, awareness/preparedness and warning systems constitute as key resilience indicators to reduce the flood risk formation of the households in Kelantan, Terengganu and Pahang, accordingly. …”
Get full text

Electrical and optoelectronic studies of semiconductor nanostructures by Wong, Jen It.

“…It was shown that the pure Si3N4 thin film and the Si3N4 thin films embedded with nc-Si are dominated by different conduction mechanisms both at low and high electric fields. Moreover, the lateral charge transfer in an nc-Si layer embedded in SiO2 thin film has been demonstrated. …”
Get full text

Surface plasmon resonance (SPR) enhanced biosensors by Zhang, Jinling

“…The sensitivity and specificity are mainly related to the sensing mechanism and binding characteristics. The sensing principle in most of my works are SPR and SPR enhanced fluorescence. …”
Get full text

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection by Alabaf, S

“…By molecular cloning and residue swapping, a region involved in the allosteric binding and its mechanism of action was narrowed down to the M2-M3 loop of the epsilon subunit.…”

The influence of pregnancy complications on fetal and neonatal cardiovascular development by Aye, C

“…As up to 8% of pregnancies are affected by hypertensive disorders of pregnancy and approximately 10% of all births are preterm, understanding the mechanisms behind these findings and their relevance to long term cardiovascular disease in this population is of great public health interest. …”

Interaction of TiO2 and ZnO NPs with human skin cells by Gautam, Archana

“…In summary, this study revealed that lower doses of TiO2 and ZnO NPs induced autophagy in keratinocyte acts as a pro-survival mechanism and protects the cell against oxidative stress and inflammation. …”
Get full text
Get full text

Kinetic modelling of 70S ribosome and F1-ATPase by Le, Quang Luan

“…For F1-ATPase , it is important to understand how F1-ATPase hydrolyzes ATP molecules based on which the mechanism of ATP synthesis is deduced due to the assumption that synthesis is just the reverse of hydrolysis. …”
Get full text

A cross-layer payload-dropping scheme for improving CSMA/CA throughput in interference-limited co-channel cells by Jayabal, Raymond J.

“…This special variant of the CSMA/CA protocol incorporates a MAC/PHY cross-layer mechanism which aborts the reception of the payload portions of frames from co-channel cells in interference-limited multi-cell deployments, based on a cell identifier embedded in the frame’s header. …”
Get full text

Structural and mechanistic studies of herpes virus proteins by Patel, Vidhi Kanaiyalal

“…Structural knowledge of ICP27 and its homologues may aid in a better understanding of the mechanism by which they function. It can give a better insight to how the virus survives and replicates in host cells. …”
Get full text

Dynamics of current-driven magnetic domain walls and skyrmions by Indra Purnama

“…At present, the investigation of domain wall dynamics is mainly focused on finding additional driving mechanisms to improve its mobility. In the case of skyrmion dynamics, the research is still in the very early stage, although it has been shown that it is possible to inject individual skyrmions individually which brings skyrmion-based devices closer to realization. …”
Get full text

Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

“…Genetics, post-mortem study and disease modelling have implicated autophagic/lysosomal dysfunction as a key pathogenic mechanism contributing to PD. Mutations in PD-related genes such as <em>GBA</em>, <em>LRRK2</em> and <em>SNCA</em> have all been implicated to present deficits in lysosomal catabolic pathways.…”

Structure and functions of a metallo-beta-lactamase- like hypothetical protein bleg1_2437 from alkali-tolerant soil bacterium Bacillus lehensis G1 by Tan, Soo Huei

“…However, the emergence of antibiotic resistance mechanism among pathogenic bacteria has downsized the efficacy of antibiotics via the production metallo-β-lactamase (MBL) which enables pathogens to destroy the β- lactam ring of β-lactam antibiotics. …”
Get full text

Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. Autoantibody-mediated processes may explain DRE in a proportion of cases. …”

Brain Informatics : 14th International Conference, BI 2021, Virtual Event, September 17-19, 2021, Proceedings / by International Conference on Brain Informatics (14th : 2021 : Online), organiser 643024, Mahmud, Mufti, editor 643025, Kaiser, M. Shamim, editor 643026, Vassanelli, Stefano, editor 643027, Dai, Qionghai, 1964-, editor 643028, Zhong, Ning, 1956-, editor 643029

Exciton Dynamics and Anisotropy in 2D Metal Organochalcogenolate Semiconductors by Lee, Woo Seok

“…Second, we explore the underlying mechanism of light emission in AgSePh and AgTePh. Despite having the same crystal structure, these compounds exhibit strikingly different excitonic properties: AgSePh shows narrow photoluminescence (PL) with a minimal Stokes shift, while AgTePh exhibits broad PL with a large Stokes shift. …”
Get full text

Optimization and scheduling for a large-scale urban transportation system involving human factors by Zhang, Yi

“…With computational complexity being a concern for our model, an evolutionary algorithm with repairing mechanism (EARM), is proposed to solve our problem. …”
Get full text

Securing untrusted memories in embedded systems by Vig, Saru

“…Next, we proposed a memory authentication framework that combines architecturespeci c optimizations of the integrity tree with mechanisms that enable it to restructure at runtime based on memory access patterns. …”
Get full text