Emerging Trends in Curcumin Embedded Electrospun Nanofibers for Impaired Diabetic Wound Healing by Ganesan Padmini Tamilarasi, Manikandan Krishnan, Govindaraj Sabarees, Siddan Gouthaman, Veerachamy Alagarsamy, Viswas Raja Solomon

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Recent Advances in Silver Nanoparticles Containing Nanofibers for Chronic Wound Management by Govindaraj Sabarees, Vadivel Velmurugan, Ganesan Padmini Tamilarasi, Veerachamy Alagarsamy, Viswas Raja Solomon

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Machine learning for small molecule drug discovery in academia and industry by Andrea Volkamer, Sereina Riniker, Eva Nittinger, Jessica Lanini, Francesca Grisoni, Emma Evertsson, Raquel Rodríguez-Pérez, Nadine Schneider

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In silico Study of Trianthema portulacastrum Embedded Iron Oxide Nanoparticles on Glycogen Synthase Kinase-3β: A Possible Contributor to its Enhanced in vivo Wound Healing Potentia... by Ekta Yadav, Pankajkumar Yadav, Amita Verma

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease by Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C. David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D. Downes, Louise Dunnett, Michael Fairhead, James D. Firth, S. Paul Jones, Aaron Keeley, György M. Keserü, Hanna F. Klein, Mathew P. Martin, Martin E. M. Noble, Peter O’Brien, Ailsa Powell, Rambabu N. Reddi, Rachael Skyner, Matthew Snee, Michael J. Waring, Conor Wild, Nir London, Frank von Delft, Martin A. Walsh

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Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands by Krzysztof Rataj, Ádám Andor Kelemen, José Brea, María Isabel Loza, Andrzej J. Bojarski, György Miklós Keserű

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Design, synthesis, in vitro, and in silico biological evaluations of coumarin-indole hybrids as new anti-α-glucosidase agents by Davood Rezapour Niri, Mohammad Hosein Sayahi, Somayeh Behrouz, Ali Moazzam, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Bagher Larijani, Hossein Rastegar, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi

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Ulcerative colitis: functional analysis of the in-depth proteome by Armin Schniers, Rasmus Goll, Yvonne Pasing, Sveinung Wergeland Sørbye, Jon Florholmen, Terkel Hansen

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Non-Invasive Delivery of Nano-Emulsified Sesame Oil-Extract of Turmeric Attenuates Lung Inflammation by Sahibzada Tasleem Rasool, Rajasekhar Reddy Alavala, Umasankar Kulandaivelu, Nagaraja Sreeharsha

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α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal by Dominik Ausbacher, Lindsey A. Miller, Darla M. Goeres, Philip S. Stewart, Morten B. Strøm, Adyary Fallarero

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Effect of An 84-bp Deletion of the Receptor-Binding Domain on the ACE2 Binding Affinity of the SARS-CoV-2 Spike Protein: An In Silico Analysis by Gábor Kemenesi, Gábor Endre Tóth, Dávid Bajusz, György M. Keserű, Gabriella Terhes, Katalin Burián, Safia Zeghbib, Balázs A. Somogyi, Ferenc Jakab

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Targeting STAT3 and STAT5 in Cancer by Elvin D. de Araujo, György M. Keserű, Patrick T. Gunning, Richard Moriggl

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Artemisinin anti-malarial drugs in China by Zongru Guo

“…This article focusing on medicinal chemistry research, briefly introduced the discovery and invention course of the scientists according to the published papers, and highlighted their academic contribution and achievements.…”
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Looking back and moving forward in medicinal chemistry

“…Nature Communications interviewed three scientists, Daniele Castagnolo (Associate Professor at University College London), Paramita Sarkar (postdoctoral researcher at University of Würzburg) and Dani Schulz (Director, Discovery Process Chemistry at Merck), about their careers and the past and future in medicinal chemistry research. We asked the researchers what medicinal chemistry means to them, and their opinions on the current relevance of the Rule of Five and new chemical modalities beyond the Rule of Five. …”
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Synthesis of heterocycle-substituted bicyclo[3.1.1]heptanes and aza-bicyclo[3.1.1]heptanes via photocatalytic minisci reaction by Revie, RI, Whitaker, BJ, Paul, B, Smith, RC, Anderson, EA

“…This chemistry enables access to heterocycle-functionalized BCHep-containing structures that are highly relevant in medicinal chemistry research as potential bioisosteres of <i>meta</i>-substituted arenes and pyridines.…”

Copper-catalyzed intramolecular C–H alkoxylation of diaryltriazoles: synthesis of tricyclic triazole benzoxazines by Ma, X, Li, H, Xin, H, Du, W, Anderson, EA, Dong, X, Jiang, Y

“…The triazole products were found to exhibit strong antifungal activity against ginseng root-rot disease, demonstrating their potential as a scaffold in medicinal chemistry research. …”

A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys by Hiroyuki Ushio, Seigo Ishibuchi, Koichi Oshita, Noriyasu Seki, Hirotoshi Kataoka, Kunio Sugahara, Kunitomo Adachi, Kenji Chiba

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<span style="font-variant: small-caps;">l</span>-Ornithine-N5-monooxygenase (PvdA) Substrate Analogue Inhibitors for <em>Pseudomonas aeruginosa</em> Infections Treatment: Drug Repu... by Joseph Christina Rosy, Ewa Babkiewicz, Piotr Maszczyk, Piotr Mrówka, Banoth Karan Kumar, Sankaranarayanan Murugesan, Selvaraj Kunjiappan, Krishnan Sundar

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Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics by Zhenzhen Xue, Bin Yang

“…The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.…”
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α-amylase and α-glucosidase antidiabetic potential of ten essential oils from Calophyllum inophyllum Linn by Emmanuel Onah Ojah, Dorcas Olufunke Moronkola, Adeniyi-Akee Mukaram Akintunde

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