Medicinal Chemistry Targeting Mitochondria: From New Vehicles and Pharmacophore Groups to Old Drugs with Mitochondrial Activity by Mabel Catalán, Ivonne Olmedo, Jennifer Faúndez, José A. Jara

“…In this context, medicinal chemistry research over the last decade has synthesized and characterized “vehicles” capable of transporting novel or existing pharmacophores to mitochondrial tumor cells, based on mechanisms that exploit the physicochemical properties of the vehicles and the inherent properties of the mitochondria. …”
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Microbiological Screening of 5-Functionalized Pyrazoles for the Future Development of Optimized Pyrazole-Based Delivery Systems by Chiara Brullo, Debora Caviglia, Andrea Spallarossa, Silvana Alfei, Scott G. Franzblau, Bruno Tasso, Anna Maria Schito

“…The pyrazole ring represents a widely applied chemical scaffold in medicinal chemistry research and we have observed that the physicochemical and biological features of highly substituted pyrazoles can be successfully improved by their encapsulation in dendrimer nanoparticles (NPs). …”
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Platinum Metal Complexes of Carbaboranylphophines: Potential Anti Cancer Agents by Ilham Maulana Ilham Maulana, Peter Loennecke Peter Loennecke, Evamarie Hey-Hawkins Evamarie Hawkins

“…The initial attraction to dicarba-closo-dodecaboranes(12) In the medicinal chemistry research, was a result of their high boron content and stability to catabolism, which are important criteria for cancer therapy, such as BNCT (boron neutron capture therapy) agents. …”
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Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review by Mustapha Suleiman, Faisal A. Almalki, Taibi Ben Hadda, Sarkar M. A. Kawsar, Subhash Chander, Sankaranarayanan Murugesan, Ajmal R. Bhat, Andrey Bogoyavlenskiy, Joazaizulfazli Jamalis

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Structural features of synthetic glycoconjugates and efficiency of their interaction with glycoprotein receptors on the surface of hepatocytes by A. S. Nosova, Yu. A. Budanova, Yu. L. Sebyakin

“…Over the last few years, medicinal chemistry research has been focusing on the creation of molecules that can target particular body systems, organs and tissues, thus abating systemic toxicity and side effects, and, most of all, boosting therapeutic potential. …”
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Molecular docking and molecular dynamics simulations discover curcumin analogs as potential wound healing agents by Govindaraj Sabarees, Vadivel Velmurugan, Viswas Raja Solomon

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Combination Drug Therapy for the Management of Alzheimer’s Disease by Md. Tanvir Kabir, Md. Sahab Uddin, Abdullah Al Mamun, Philippe Jeandet, Lotfi Aleya, Rasha A. Mansouri, Ghulam Md Ashraf, Bijo Mathew, May N. Bin-Jumah, Mohamed M. Abdel-Daim

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Design, synthesis, in silico, and pharmacological evaluation of novel quinoline derivatives containing substituted piperazine moieties as potential anti-breast cancer agents by Muthiah Gnana Ruba Priya, Viswas Raja Solomon, Nagarajan Hemavathy, Jeyaraman Jeyakanthan, Dileep Kumar, Jahnavi Mahesh

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Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes by Rebecca Riise, Lina Odqvist, Johan Mattsson, Susan Monkley, Suado M. Abdillahi, Christian Tyrchan, Daniel Muthas, Linda Fahlén Yrlid

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Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates by Carlos García-Estrada, Yolanda Pérez-Pertejo, Bárbara Domínguez-Asenjo, Vanderlan Nogueira Holanda, Sankaranarayanan Murugesan, María Martínez-Valladares, Rafael Balaña-Fouce, Rosa M. Reguera

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Development of surface-engineered PLGA nanoparticulate-delivery system of Tet-1-conjugated nattokinase enzyme for inhibition of Aβ40 plaques in Alzheimer’s disease by Bhatt PC, Verma A, Al-Abassi FA, Anwar F, Kumar V, Panda BP

“…Prakash Chandra Bhatt,1 Amita Verma,2 Fahad A Al-Abbasi,3 Firoz Anwar,3 Vikas Kumar,4 Bibhu Prasad Panda1 1Microbial and Pharmaceutical Biotechnology Laboratory, Centre for Advanced Research in Pharmaceutical Science, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India; 2Bioorganic & Medicinal Chemistry Research Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India; 3Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia; 4Natural Product Drug Discovery Laboratory, Department of Pharmaceutical Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad, Uttar Pradesh, India Abstract: According to the World Health Organization, globally there are around 18 million patients suffering from Alzheimer’s disease (AD), and this number is expected to double by 2025. …”
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Synthesis, Docking Studies and Acetylcholinesterase Inhibition of Open-Chain Carbohydrate Amides by Maria Isabel Ismael, Rita Gonçalves-Pereira, Susana D. Lucas, José Albertino Figueiredo, Maria Isabel García-Moreno, Carmen Mellet, Amélia Pilar Rauter

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Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations by Rani Sasidharan, Bo Hyun Eom, Jeong Hyun Heo, Jong Eun Park, Mohamed A. Abdelgawad, Arafa Musa, Nicola Gambacorta, Orazio Nicolotti, Sreedharannair Leelabaiamma Manju, Bijo Mathew, Hoon Kim

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Structural Implications of STAT3 and STAT5 SH2 Domain Mutations by Elvin D. de Araujo, Anna Orlova, Heidi A. Neubauer, Dávid Bajusz, Hyuk-Soo Seo, Sirano Dhe-Paganon, György M. Keserű, Richard Moriggl, Patrick T. Gunning

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A Validated HPLC-PDA-HRMS Method to Investigate the Biological Stability and Metabolism of Antiparasitic Triterpenic Esters by Laura Schioppa, Fanta Fall, Sergio Ortiz, Jacques H. Poupaert, Joelle Quetin-Leclercq

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Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective by Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Veena Vijayan, Deepak Kumar, Jashwanth Naik, Suresh Thareja, Jagat Pal Yadav, Prateek Pathak, Maria Grishina, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid Emwas, Pradeep Kumar

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Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria by Fernando Durães, Diana I. S. P. Resende, Andreia Palmeira, Nikoletta Szemerédi, Madalena M. M. Pinto, Gabriella Spengler, Emília Sousa

“…The search for new compounds with the potential to help in the reversion of bacterial resistance plays an important role in current medicinal chemistry research. Under this scope, bacterial efflux pumps are responsible for the efflux of antimicrobials, and their inhibition could reverse resistance. …”
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Lichen Xanthones as Models for New Antifungal Agents by Diana I. S. P. Resende, Patrícia Pereira-Terra, Ângela S. Inácio, Paulo Martins da Costa, Eugénia Pinto, Emília Sousa, Madalena M. M. Pinto

“…Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for new antimicrobial compounds plays an important role in current medicinal chemistry research. Inspired by lichen antimicrobial xanthones, a series of novel chlorinated xanthones was prepared using five chlorination methods (Methods A–E) to obtain different patterns of substitution in the xanthone scaffold. …”
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Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification by Zhipeng Lin, Uttam Dhawa, Xiaoyan Hou, Max Surke, Binbin Yuan, Shu-Wen Li, Yan-Cheng Liou, Magnus J. Johansson, Li-Cheng Xu, Chen-Hang Chao, Xin Hong, Lutz Ackermann

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ABCG2 polymorphisms and susceptibility to ARV‐associated hepatotoxicity by HariOm Singh, Kishore Dhotre, Shyamveer, Ranjana Choudhari, Amita Verma, Supriya D. Mahajan, Nemat Ali

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