A model of hippocampal replay driven by experience and environmental structure facilitates spatial learning by Nicolas Diekmann, Sen Cheng

“…Replay of neuronal sequences in the hippocampus during resting states and sleep play an important role in learning and memory consolidation. Consistent with these functions, replay sequences have been shown to obey current spatial constraints. …”
Get full text

Involvement of l-lactate in hippocampal dysfunction of type I diabetes by Riho Kobayashi, Junya Maruoka, Hiroaki Norimoto, Yuji Ikegaya, Kazuhiko Kume, Masahiro Ohsawa

“…Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of l-lactate, a major neural energy source. …”
Get full text

Role of optimum diagnosis and treatment of insomnia in patients with hypertension and diabetes: A review by Himanshu Garg

“…Sleep plays a pivotal role in regulation and function of the central nervous system (CNS) and other physiological functions of the body such as regulation of body temperature, metabolism, catabolism, learning, and memory consolidation. Therefore, sleep is not a mere passive state, but it is a highly organized interaction of neural networks and neurotransmitters of the CNS which maintain active neurobehavioral state. …”
Get full text

Activity-dependent plasticity of mouse hippocampal assemblies in vitro by Martin eKeller, Martin eBoth, Andreas eDraguhn, Susanne eReichinnek, Susanne eReichinnek

“…One of these patterns, sharp wave-ripple complexes (SPW-R), repetitively activates previously established groups of memory-encoding neurons, thereby supporting memory consolidation. This function implies that repetition of specific SPW-R induces plastic changes which render the underlying neuronal assemblies more stable. …”
Get full text

A medullary hub for controlling REM sleep and pontine waves by Amanda L. Schott, Justin Baik, Shinjae Chung, Franz Weber

“…Phasic bursts of electrical activity, measurable as spike-like pontine (P)-waves, are a hallmark of REM sleep implicated in memory consolidation. However, the brainstem circuits regulating P-waves, and their interactions with circuits generating REM sleep, remain largely unknown. …”
Get full text

Drug Targets for Cardiovascular-Safe Anti-Inflammatory: In Silico Rational Drug Studies. by Sajad Shahbazi, Tammanna R Sahrawat, Monalisa Ray, Swagatika Dash, Dattatreya Kar, Shikha Singh

“…Cyclooxygenase-2 (COX-2) plays an important role in memory consolidation and synaptic activity, the most fundamental functions of the brain. …”
Get full text

Memory engram storage and retrieval by Tonegawa, Susumu, Pignatelli di Spinazzola, Michele, Roy, Dheeraj, Ryan, Tomas John

“…Recent research has employed this technology to probe fundamental questions of memory consolidation, differentiating between mechanisms of memory retrieval and the true neurobiology of memory storage.…”
Get full text
Get full text
Get full text
Get full text

Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders by Vyazovskiy, V, McKillop, L, Purple, R, Blanco-Duque, C, Peirson, S, Foster, R, Harrison, P, Sprengel, R, Davies, K, Oliver, P, Bannerman, D

“…Sleep EEG spindles have been implicated in attention, sensory processing, synaptic plasticity and memory consolidation. In humans, deficits in sleep spindles have been reported in a wide range of neurological and psychiatric disorders, including schizophrenia. …”

A developmental increase of inhibition promotes the emergence of hippocampal ripples by Irina Pochinok, Tristan M. Stöber, Jochen Triesch, Mattia Chini, Ileana L. Hanganu-Opatz

“…Abstract Sharp wave-ripples (SPW-Rs) are a hippocampal network phenomenon critical for memory consolidation and planning. SPW-Rs have been extensively studied in the adult brain, yet their developmental trajectory is poorly understood. …”
Get full text

A neuromorphic architecture for object recognition and motion anticipation using burst-STDP. by Andrew Nere, Umberto Olcese, David Balduzzi, Giulio Tononi

“…Furthermore, this learning algorithm takes advantage of homeostatic renormalization, which has been hypothesized to promote memory consolidation during NREM sleep. Using this learning rule, we design a spiking neural network architecture capable of object recognition, motion detection, attention towards important objects, and motor control outputs. …”
Get full text

Class I histone deacetylases inhibition reverses memory impairment induced by acute stress in mice. by Heidy Martínez-Pacheco, Rossana Citlali Zepeda, Ofir Picazo, Gina L Quirarte, Gabriel Roldán-Roldán

“…While chronic stress induces learning and memory impairments, acute stress may facilitate or prevent memory consolidation depending on whether it occurs during the learning event or before it, respectively. …”
Get full text

Metaphor and hyperassociativity: the imagination mechanisms behind emotion assimilation in sleep and dreaming by Josie Elizabeth Malinowski, Caroline eHorton

“…While many theories previously have posited a role for emotion processing and/or emotional memory consolidation during sleep and dreaming, sleep theories often do not take enough account of important dream science data, yet dream research, when conducted systematically and under ideal conditions, can greatly enhance theorising around the functions of sleep. …”
Get full text

Filopodia: A Rapid Structural Plasticity Substrate for Fast Learning by Ahmet S. Ozcan

“…These propositions aim to introduce a unifying framework for a diversity of phenomena in the brain such as synaptogenesis, pruning and memory consolidation.…”
Get full text

Persistence of hippocampal and striatal multivoxel patterns during awake rest after motor sequence learning by Bradley R. King, Mareike A. Gann, Dante Mantini, Julien Doyon, Geneviève Albouy

“…Summary: Memory consolidation, the process by which newly encoded and fragile memories become more robust, is thought to be supported by the reactivation of brain regions - including the hippocampus - during post-learning rest. …”
Get full text

Comparing targeted memory reactivation during slow wave sleep and sleep stage 2 by Julia Carbone, Carlos Bibian, Jan Born, Cecilia Forcato, Susanne Diekelmann

“…Abstract Sleep facilitates declarative memory consolidation, which is assumed to rely on the reactivation of newly encoded memories orchestrated by the temporal interplay of slow oscillations (SO), fast spindles and ripples. …”
Get full text

Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory by Mariana R. Matos, Esther Visser, Ioannis Kramvis, Rolinka J. van der Loo, Titia Gebuis, Robbert Zalm, Priyanka Rao-Ruiz, Huibert D. Mansvelder, August B. Smit, Michel C. van den Oever

“…Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.…”
Get full text

Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples by Hong-Viet Ngo, Juergen Fell, Bernhard Staresina

“…Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. …”
Get full text

Analysis of sleep spindles in children with Asperger’s syndrome by Rodolfo Cebreros-Paniagua, Fructuoso Ayala-Guerrero, Erik Leonardo Mateos-Salgado, Christopher Isaac Villamar-Flores, Carlos Alberto Gutiérrez-Chávez, Ulises Jiménez-Correa

“…Sleep spindles are associated to sleep stability functions as well as memory consolidation and optimization of different cognitive processes. …”
Get full text

Sleep Research in the Era of AI by Pinar Göktepe-Kavis, Florence M. Aellen, Sigurd L. Alnes, Athina Tzovara

“…It spans from the diagnosis of sleep-related disorders to investigations of how sleep supports memory consolidation. The study of sleep includes a variety of approaches, starting with the sole focus on the visual interpretation of polysomnography characteristics and extending to the emergent use of advanced signal processing tools. …”
Get full text

Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder. by Alexander Prehn-Kristensen, Manuel Munz, Ina Molzow, Ines Wilhelm, Christian D Wiesner, Lioba Baving

“…The emotional memory bias was baseline-corrected, and groups were compared in terms of sleep-dependent memory consolidation (sleep vs. wake). We observed an increased sleep-dependent emotional memory bias in healthy children compared to children with ADHD and healthy adults. …”
Get full text