Experimental sleep deprivation as a tool to test memory deficits in rodents by VALERIA eCOLAVITO, Paolo Francesco Fabene, Gigliola eGrassi Zucconi, Fabien ePifferi, Yves eLamberty, Marina eBentivoglio, Giuseppe eBertini

“…Total SD, partial or state-selective SD (rapid eye movement SD) procedures are first reviewed, followed by procedures to investigate SD-induced impairment of learning and memory consolidation. Thus, a platform of knowledge is here provided for laboratory protocols that could be used to assess the efficacy of drugs designed to improve memory performance in rodents, including rodent models of neurodegenerative diseases that cause cognitive deficits, and Alzheimer’s disease in particular. …”
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Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice by Toyoda Hiroki, Zhao Ming-Gao, Mercaldo Valentina, Chen Tao, Descalzi Giannina, Kida Satoshi, Zhuo Min

“…<p>Abstract</p> <p>Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP-responsive element binding protein (CREB), which plays key roles in synaptic plasticity and memory consolidation. Our previous study showed that long-term potentiation (LTP) in the anterior cingulate cortex (ACC) was significantly enhanced in transgenic mice overexpressing CaMKIV. …”
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Theta-modulation drives the emergence of connectivity patterns underlying replay in a network model of place cells by Panagiota Theodoni, Bernat Rovira, Yingxue Wang, Alex Roxin

“…When the animal is quiescent or sleeping, one can observe similar sequences of activation known as replay, which underlie the process of memory consolidation. However, it remains unclear how replay is generated. …”
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Thalamocortical and intracortical laminar connectivity determines sleep spindle properties. by Giri P Krishnan, Burke Q Rosen, Jen-Yung Chen, Lyle Muller, Terrence J Sejnowski, Sydney S Cash, Eric Halgren, Maxim Bazhenov

“…Spindle density and synchronization properties are different in MEG versus EEG recordings in humans and also vary with learning performance, suggesting spindle involvement in memory consolidation. Here, using computational models, we identified network mechanisms that may explain differences in spindle properties across cortical structures. …”
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CPEB3 Deficiency Elevates TRPV1 Expression in Dorsal Root Ganglia Neurons to Potentiate Thermosensation. by Sitt Wai Fong, Hsiu-Chen Lin, Meng-Fang Wu, Chih-Cheng Chen, Yi-Shuian Huang

“…Activity-induced synthesis of PRPs maintains long-lasting synaptic changes that are critical for memory consolidation and chronic pain manifestation. CPEB3-knockout (KO) mice show aberrant hippocampus-related plasticity and memory, so we investigated whether CPEB3 might have a role in nociception-associated plasticity. …”
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Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling. by David E Kram, Stephanie M Krasnow, Peter R Levasseur, Xinxia Zhu, Linda C Stork, Daniel L Marks

“…Sleep disturbance can negatively impact overall quality of life, neurodevelopment, memory consolidation, and wound healing. Hypothalamic orexin neurons are influential wake-promoting neurons, and disturbances in orexin signaling leads to abnormal sleep behavior. …”
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The effect of cathodal transcranial direct current stimulation during rapid eye-movement sleep on neutral and emotional memory by Jennifer M. Johnson, Simon J. Durrant

“…Sleep-dependent memory consolidation has been extensively studied. Neutral declarative memories and serial reaction time task (SRTT) performance can benefit from slow-wave activity, characterized by less than 1 Hz frequency cortical slow oscillations (SO). …”
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Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1 by Marc A. Wolman, Eric D. de Groh, Sean M. McBride, Thomas A. Jongens, Michael Granato, Jonathan A. Epstein

“…We show that nf1-deficient zebrafish exhibit learning and memory deficits and that acute pharmacological inhibition of downstream targets of Ras (MAPK and PI3K) restores memory consolidation and recall but not learning. Conversely, acute pharmacological enhancement of cAMP signaling restores learning but not memory. …”
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Control of cortical oscillatory frequency by a closed-loop system by Mattia D’Andola, Massimiliano Giulioni, Vittorio Dante, Paolo Del Giudice, Maria V. Sanchez-Vives

“…Conclusions Our tool opens new possibilities for the investigation of dynamics of cortical slow oscillations—an activity pattern that is associated with cognitive processes such as memory consolidation, and that is altered in several neurological conditions—and also for potential applications of this technology.…”
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KALP BİR POMPADAN ÖTE BİR ŞEY OLAMAZ MI? by Ahmet Nacar

“…Bunun da ötesinde SA düğümüne yapılacak çeşitli müdahelelerin, altında istenmeyen anıların ve yaşam deneyimlerinin yattığı düşünülen bazı psikiyatrik hastalıklarda tedavi amaçlı olarak kullanılabileceği önerisi de tartışıldı.ABSTRACTBased on the 1) personality changes observed following heart transplantations; 2) the two-way, dynamic, ongoing dialog between the brain and the heart and its reflection as alterations in heart rate variability; 3) the prominent role of amygdala in cardiovascular regulation during rapid eye movement sleep and 4) the importance of rapid eye movement sleep in the developing brain to establish proper neuronal circuits and its memory consolidation effect; 5) the role of cardiac neural crest cells in heart development and 6) the effects of Atrial and Brain Natriuretic Peptides; I hypothesize that the heart, particularly the SA node, could function in emotional memory processing and storage in collaboration with related brain regions. …”
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Sex Differences in Sleep Architecture After Traumatic Brain Injury: Potential Implications on Short-Term Episodic Memory and Recovery by Stefanie N. Howell, Grace S. Griesbach

“…Such disturbances in sleep can lead to deficits in executive functioning, attention, and memory consolidation, which may ultimately impact the recovery process. …”
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Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits by Arash Yazdanbakhsh, Helen Barbas, Basilis Zikopoulos

“… AbstractSleep spindles are associated with the beginning of deep sleep and memory consolidation and are disrupted in schizophrenia and autism. …”
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Deterioration and Recovery in Verbal Recall: Repetition Helps against Pro-Active Interference by Lange-Kuettner, Christiane, Markowska, Monika, Ridhi, Kochhar

“…The current study tests whether memory deterioration due to pro-active interference (PI) in verbal recall could be halted via block repetition potentially leading to an increased memory consolidation. We also tested whether bilinguals would be better shielded against memory deterioration than monolinguals because they constantly need to enrich their vocabulary to compensate for their smaller lexica in either language. …”
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Sleeping with hippocampal damage by Spanò, G, Weber, FD, Pizzamiglio, G, McCormick, C, Miller, TD, Rosenthal, CR, Edgin, JO, Maguire, EA

“…The shift of patients’ spindles into the later phase of the up-state within the SO cycle may indicate a mismatch in timing across the SO-spindle-ripple events that are associated with memory consolidation [6, 7]. The substantial effect of selective bilateral hippocampal damage on large-scale oscillatory activity in the cortex suggests that, as with awake cognition, the hippocampus plays a significant role in sleep physiology, which may, in turn, be necessary for efficacious episodic memory. …”

LSD1 is an environmental stress-sensitive negative modulator of the glutamatergic synapse by A. Longaretti, C. Forastieri, E. Toffolo, L. Caffino, A. Locarno, I. Misevičiūtė, E. Marchesi, M. Battistin, L. Ponzoni, L. Madaschi, C. Cambria, M.P. Bonasoni, M. Sala, D. Perrone, F. Fumagalli, S. Bassani, F. Antonucci, R. Tonini, M. Francolini, E. Battaglioli, F. Rusconi

“…Along with neuronal mechanisms devoted to memory consolidation –including long term potentiation of synaptic strength as prominent electrophysiological correlate, and inherent dendritic spines stabilization as structural counterpart– negative control of memory formation and synaptic plasticity has been described at the molecular and behavioral level. …”
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Theta Phase-Coordinated Memory Reactivation Reoccurs in a Slow-Oscillatory Rhythm during NREM Sleep by Thomas Schreiner, Christian F. Doeller, Ole Jensen, Björn Rasch, Tobias Staudigl

“…Summary: It has been proposed that sleep’s contribution to memory consolidation is to reactivate prior encoded information. …”
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Balancing Prediction and Surprise: A Role for Active Sleep at the Dawn of Consciousness? by Matthew N. Van De Poll, Bruno van Swinderen

“…Emotional responses are understood to be important for memory consolidation, suggesting that positive or negative ‘valence’ cues more generally constitute an ancient mechanism designed to potently refine and generalize internal models of the world and thereby minimize prediction errors. …”
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Improving old tricks as new: Young adults learn from repeating everyday activities. by Gil Meir Leizerowitz, Ran Gabai, Meir Plotnik, Ofer Keren, Avi Karni

“…Significant intra-session and inter-session changes occurred in step kinematics as well; some aspects underwent inter-sessions recalibrations, but other aspects showed delayed inter-session changes, suggesting post-practice memory consolidation processes. Even common everyday tasks can be improved upon by practice; a small number of consecutive task repetitions can trigger lasting gains in young healthy individuals performing highly practiced routine tasks. …”
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Development and Study of Ezzence: A Modular Scent Wearable to Improve Wellbeing in Home Sleep Environments by Judith Amores, Judith Amores, Mae Dotan, Pattie Maes

“…The device is integrated with a wearable EEG and real-time sleep staging algorithm to release scent during specific sleep stages (N1, N2, N3, and REM), which is important for certain use cases (e.g., to study the effect of scent on REM dreams, or to improve memory consolidation with a re-exposure of scent during N2 and N3). …”
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APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone. by Melanie Laßek, Jens Weingarten, Martin Wegner, Benjamin F Mueller, Marion Rohmer, Dominic Baeumlisberger, Tabiwang N Arrey, Meike Hick, Jörg Ackermann, Amparo Acker-Palmer, Ina Koch, Ulrike Müller, Michael Karas, Walter Volknandt

“…The pathogenesis involves a successive loss of hippocampal neurons accompanied by a decline in learning and memory consolidation mainly attributed to an accumulation of senile plaques. …”
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