Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides by Beata Żołnowska, Jarosław Sławiński, Mariusz Belka, Tomasz Bączek, Anna Kawiak, Jarosław Chojnacki, Aneta Pogorzelska, Krzysztof Szafrański

Subjects: Get full text

Evaluation of the metabolism of PEP06, an endostatin-RGDRGD 30-amino-acid polypeptide and a promising novel drug for targeting tumor cells by Liyun Niu, Huiyu Zhou, Yueru Lian, Ya Gao, Yulu Liu, Ruolan Gu, Zhuona Wu, Xiaoxia Zhu, Hui Gan, Zhiyun Meng, Guifang Dou

Subjects: Get full text

Ecofriendly, Simple, Fast and Sensitive UPLC-MS/MS Method for Determination of Erdafitinib, a Novel Tyrosine Kinase Inhibitor, in Plasma and Its Application to Metabolic Stability by Essam A. Ali, Muzaffar Iqbal, Gamal A. Mostafa, Mohamed R. Alhazani, Yousif A. Asiri

Subjects: Get full text

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability by Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen

Subjects: Get full text

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability by Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Huri Piao, Fener Chen

Subjects: Get full text

In vitro and in vivo pharmacokinetic characterization of LMT-28 as a novel small molecular interleukin-6 inhibitor by Sung-Hoon Ahn, Tae-Hwe Heo, Hyun-Sik Jun, Yongseok Choi

Subjects: Get full text

Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study by Muzaffar Iqbal, Essam A. Ali, Mohd Abul Kalam, Sheikh F. Ahmad, Rashad Al-Salahi

Subjects: Get full text

Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals by Brendan J. Evans, Andrew T. King, Andrew Katsifis, Lidia Matesic, Joanne F. Jamie

Subjects: Get full text

Discovery of Dipyridamole Analogues with Enhanced Metabolic Stability for the Treatment of Idiopathic Pulmonary Fibrosis by Meng-Xing Huang, Yan-Quan Chen, Run-Duo Liu, Yue Huang, Chen Zhang

Subjects: Get full text

Morpho-Anatomical and Physiological Assessments of Cryo-Derived Pineapple Plants (<i>Ananas comosus</i> var. <i>comosus</i>) after Acclimatization by Ariel Villalobos-Olivera, José Carlos Lorenzo-Feijoo, Nicolás Quintana-Bernabé, Michel Leiva-Mora, Jean Carlos Bettoni, Marcos Edel Martínez-Montero

Subjects: Get full text

Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient by Hyeon Kim, Min Sun Choi, Young Seok Ji, In Sook Kim, Gi Beom Kim, In Yong Bae, Myung Chan Gye, Hye Hyun Yoo

Subjects: Get full text

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma by Ines Greco, Bernard D. Hummel, Jaspreet Vasir, Jeffrey L. Watts, Jason Koch, Johannes E. Hansen, Hanne Mørck Nielsen, Peter Damborg, Paul R. Hansen

Subjects: Get full text

The Metabolic Stability of the Nicotinic Acetylcholine Receptor at the Neuromuscular Junction by Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboune

Subjects: Get full text

Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity by Małgorzata Anna Marć, Enrique Domínguez-Álvarez, Gniewomir Latacz, Agata Doroz-Płonka, Carmen Sanmartín, Gabriella Spengler, Jadwiga Handzlik

Subjects: Get full text

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules by Sanjeev Kumar V. Vernekar, Rajkumar Lalji Sahani, Mary C. Casey, Jayakanth Kankanala, Lei Wang, Karen A. Kirby, Haijuan Du, Huanchun Zhang, Philip R. Tedbury, Jiashu Xie, Stefan G. Sarafianos, Zhengqiang Wang

Subjects: Get full text

Antrodin C, an NADPH Dependent Metabolism, Encourages Crosstalk between Autophagy and Apoptosis in Lung Carcinoma Cells by Use of an AMPK Inhibition-Independent Blockade of the Akt... by Hairui Yang, Xu Bai, Henan Zhang, Jingsong Zhang, Yingying Wu, Chuanhong Tang, Yanfang Liu, Yan Yang, Zhendong Liu, Wei Jia, Wenhan Wang

Subjects: Get full text

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry by Attwa MW, Kadi AA, Darwish HW

Subjects: Get full text

Metabolite Identification of a Novel Anti-Leishmanial Agent OJT007 in Rat Liver Microsomes Using LC-MS/MS by Maria Eugenia Rincon Nigro, Ting Du, Song Gao, Manvir Kaur, Huan Xie, Omonike Arike Olaleye, Dong Liang

Subjects: Get full text

Interpretation of multi-task clearance models from molecular images supported by experimental design by Andrés Martínez Mora, Mickael Mogemark, Vigneshwari Subramanian, Filip Miljković

Subjects: “…Metabolic stability…”
Get full text

Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism by Yang Liu, Jiaqi Zhang, Di Wu, Liran Cui

Subjects: “…metabolic stability…”
Get full text