An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration by Tao Yang, Zhichao Hao, Zhenzhen Wu, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li, Wei Teng

“…The present study provides a bioinspired strategy for completely resembling complex hierarchy of compact mineralized tissue, and offers a critical research model for in-depth studying the structure-function relationship of bone.…”
Get full text

Apical Negative Pressure irrigation presents tissue compatibility in immature teeth by Carolina Maschietto Pucinelli, Léa Assed Bezerra da Silva, Nestor Cohenca, Priscilla Coutinho Romualdo, Raquel Assed Bezerra da Silva, Alberto Consolaro, Alexandra Mussolino de Queiroz, Paulo Nelson Filho

“…The ANP group showed a predominance of low magnitude inflammatory infiltrate, a smaller periodontal ligament, and lower mineralized tissue resorption. There were no differences in the periapical lesion extensions between the ANP and conventional groups (p>0.05). …”
Get full text

Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model by Omair A. Mohiuddin, Brett Campbell, J. Nick Poche, Michelle Ma, Michelle Ma, Emma Rogers, Dina Gaupp, Mark A. A. Harrison, Bruce A. Bunnell, Daniel J. Hayes, Jeffrey M. Gimble, Jeffrey M. Gimble

“…Histological analyses revealed that all treatments resulted in significantly higher tissue areas with the relative mineralized tissue area significantly increased at 12 weeks; however, cartilaginous content was lowest among treatment groups with OIASC. …”
Get full text

A clinico-radiographic and histomorphometric analysis of alveolar ridge preservation using calcium phosphosilicate, PRF, and collagen plug by Tarun Kumar AB, Chaitra N. T., Gayatri Divya PS, M. G. Triveni, Dhoom Singh Mehta

“…The histomorphometric evaluation depicted the vital bone volume of 54.5 ± 16.76%, non-mineralized tissue 43.50 ± 15.80%, and residual material 2.00 ± 3.37%. …”
Get full text

Osteoconductive Properties of a Volume-Stable Collagen Matrix in Rat Calvaria Defects: A Pilot Study by Karol Alí Apaza Alccayhuaman, Stefan Tangl, Stéphane Blouin, Markus A. Hartmann, Patrick Heimel, Ulrike Kuchler, Jung-Seok Lee, Reinhard Gruber

“…Microcomputed tomography showed the overall mineralized tissue in the defect to be 1.6 mm³ (min 0.0; max 13.3). …”
Get full text

3D Printed Polyurethane Scaffolds for the Repair of Bone Defects by Megan E. Cooke, Megan E. Cooke, Jose L. Ramirez-GarciaLuna, Jose L. Ramirez-GarciaLuna, Karla Rangel-Berridi, Karla Rangel-Berridi, Hyeree Park, Showan N. Nazhat, Michael H. Weber, Michael H. Weber, Janet E. Henderson, Janet E. Henderson, Derek H. Rosenzweig, Derek H. Rosenzweig

“…Implantation into a mandibular defect showed significantly increased mineralized tissue production when compared to a currently approved bone putty. …”
Get full text

Pulp regeneration with hemostatic matrices as a scaffold in an immature tooth minipig model by Ji-Hyun Jang, Joung-Ho Moon, Sahng Gyoon Kim, Sun-Young Kim

“…The PC and GM groups showed favorable root development without inflammation and newly mineralized tissue deposited in the root canal system, while FM group presented inflammatory changes with the continuation of root development. …”
Get full text

Bone mineral properties and 3D orientation of human lamellar bone around cement lines and the Haversian system by Tilman A. Grünewald, Andreas Johannes, Nina K. Wittig, Jonas Palle, Alexander Rack, Manfred Burghammer, Henrik Birkedal

“…Bone is the only mineralized tissue that can be remodeled and, at the start of the formation of new bone during this process, a structure called a cement line is formed on which regular bone grows. …”
Get full text

Bone morphogenetic proteins 2, 6, and 9 differentially regulate the osteogenic differentiation of immortalized preodontoblasts by Yuying Cao, Qin Tan, Jing Li, Jinhua Wang

“…Several BMPs retained endogenous expression in PDBs and regulated the mRNA expression of mineralized tissue-associated proteins. ALP activity and mineralized nodule formation were significantly increased in the Ad-BMP9-transfected group relative to the control group. …”
Get full text

Hyaluronan Synthases’ Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells by Sebastian Reiprich, Elif Akova, Attila Aszódi, Veronika Schönitzer

“…During biomineralization, the cells generating the biominerals must be able to sense the external physical stimuli exerted by the growing mineralized tissue and change their intracellular protein composition according to these stimuli. …”
Get full text

Molecular Spectroscopic Imaging Offers a Systematic Assessment of Pathological Aortic Valve and Prosthesis Tissue in Biomineralization by Claudia Dittfeld, Alice Mieting, Cindy Welzel, Anett Jannasch, Klaus Matschke, Sems-Malte Tugtekin, Gerald Steiner

“…Results of histological von Kossa staining to monitor hydroxyapatite biomineralization correlated to the definition of mineralized tissue using FT-IR spectroscopic imaging. Spectra exhibit signals of carbonate and phosphate groups of hydroxyapatite. …”
Get full text

Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo by Tomaz Alves, Letícia M. Gasparoni, Danilo Balzarini, Emmanuel Albuquerque-Souza, Victhor de Oliveira, Emanuel S. Rovai, Jose da Silva, Aldrin Huamán-Mendoza, Luiz H. Catalani, Carla R. Sipert, Marinella Holzhausen

“…Immunohistochemistry for bone sialoprotein (BSP), integrin β1 and collagen type 1 and histological stains (H&E, Van Giesson, Masson’s Trichrome and Von Kossa) were performed on the ex-vivo mineralized tissue after 60 days of implantation in vivo. …”
Get full text

Characteristics of materials used as cervical barrier in pulp revascularization: an integrative review by Jussara Santos Valença, Maira Prado

“…As an inconvenience to its use, coronal discoloration is reported in vitro due to MTA, Biodentine and Endosequence, and in vivo only due to MTA. In addition, mineralized tissue may form inside the root canal, possibly due to the bioactivity of these materials.…”
Get full text

A Proposed Mechanism for Congenitally Missing Teeth: Basic and Clinical Evidence by Gajanan Kulkarni, Reiko Nomura, Ka-On Laurel Lee, Seema Shah

“…Introduction: Although the de-velopment of normal dentition has been explored extensively, the mechanisms underlying congenitally missing teeth are far less understood.The hypothesis: Congenital absence of teeth occurs due to arrested development of a tooth primordium followed by involution, only at a stages preceding mineralized tissue formation.Evaluation of the hypothesis: We compared H & E stained serial sagittal sections of wild-type and EL mice that are congenitally missing 3rd molars (3M). 3M development was followed longitudinally in both types of mice. …”
Get full text

Effect of different low-level intensity laser therapy (LLLT) irradiation protocols on the osseointegration of implants placed in grafted areas by Guilherme José Pimentel Lopes de OLIVEIRA, Felipe Eduardo PINOTTI, Maurício Andres Tinajero ARONI, Elcio MARCANTONIO JR, Rosemary Adriana Chiérici MARCANTONIO

“…Results The LLLT groups presented higher removal torque, mineralized tissue volume, and a greater degree of osseointegration, especially when LLLT was performed only after implant placement, and these findings were associated with higher expression of BMP2 and alkaline phosphatase. …”
Get full text

Regenerative approach to bilateral rostral mandibular reconstruction in a case series of dogs by Boaz eArzi, Derek D Cissell, Rachel E Pollard, Frank J.M. Verstraete

“…Two dogs had the complication of focal plate exposure and dehiscence, which was corrected with mucosal flaps and suturing; these dogs have since healed with intact gingival covering over the mandibular defect. Mineralized tissue formation was palpated clinically within 2 weeks and solid bone formation within 3 months. …”
Get full text

Helium ion microscopy of enamel crystallites and extracellular tooth enamel matrix by Felicitas B Bidlack, Chuong eHuynh, Jeffrey eMarshman, Bernhard eGoetze

“…Second, our results illustrate that the combination of these techniques is a powerful approach to elucidate the 3D structural organization of organic matrix molecules in mineralizing tissue in nanometer resolution.…”
Get full text

A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone by Laure Thibaudeau, Anna V. Taubenberger, Boris M. Holzapfel, Verena M. Quent, Tobias Fuehrmann, Parisa Hesami, Toby D. Brown, Paul D. Dalton, Carl A. Power, Brett G. Hollier, Dietmar W. Hutmacher

“…The tissue-engineered constructs led to the formation of a morphologically intact ‘organ’ bone incorporating a high amount of mineralized tissue, live osteocytes and bone marrow spaces. …”
Get full text

Composition, structure and model of the formation of conodont lamellar tissue by A. V. Zhuravlev

“…This research was focused on the most common mineralized tissue that composes conodont elements. The aim was to investigate the characteristics of the composition and structure of this tissue and to reconstruct its formation process. …”
Get full text

Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro by Runze Jin, Guangtai Song, Jihua Chai, Xiaohui Gou, Guohua Yuan, Zhi Chen

“…Interestingly, in comparison to the controls, the low doses (<50%) of concentrated growth factor increased cell migration, alkaline phosphatase activity, and mineralized tissue deposition, while the cells treated in high doses (50% or 80%) showed no significant difference. …”
Get full text