Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice by Benjamin A. Kugler, Jared Lourie, Nicolas Berger, Nana Lin, Paul Nguyen, Edzana DosSantos, Abir Ali, Amira Sesay, H. Grace Rosen, Baby Kalemba, Gregory M. Hendricks, Joseph A. Houmard, Hiromi Sesaki, Philimon Gona, Tongjian You, Zhen Yan, Kai Zou

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Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids by Dogan Grepper, Cassandra Tabasso, Axel K.F. Aguettaz, Adrien Martinotti, Ammar Ebrahimi, Sylviane Lagarrigue, Francesca Amati

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Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition by Serge Ducommun, Paulo R. Jannig, Igor Cervenka, Marta Murgia, Melanie J. Mittenbühler, Ekaterina Chernogubova, José M. Dias, Baptiste Jude, Jorge C. Correia, Jonathan G. Van Vranken, Gabriel Ocana-Santero, Margareta Porsmyr-Palmertz, Sarah McCann Haworth, Vicente Martínez-Redondo, Zhengye Liu, Mattias Carlström, Matthias Mann, Johanna T. Lanner, Ana I. Teixeira, Lars Maegdefessel, Bruce M. Spiegelman, Jorge L. Ruas

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Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion by Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, David Tarussio, Maxime Jan, Ana Rodriguez Sanchez-Archidona, Sophie Croizier, Bernard Thorens

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Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy by Joseph J. Bass, Asif Nakhuda, Colleen S. Deane, Matthew S. Brook, Daniel J. Wilkinson, Bethan E. Phillips, Andrew Philp, Janelle Tarum, Fawzi Kadi, Ditte Andersen, Amadeo Muñoz Garcia, Ken Smith, Iain J. Gallagher, Nathaniel J. Szewczyk, Mark E. Cleasby, Philip J. Atherton

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NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition by Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna–Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hövelmeyer, Jens C. Brüning, F. Thomas Wunderlich

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Intestinal GPR119 activation by microbiota-derived metabolites impacts feeding behavior and energy metabolism by Miki Igarashi, Tetsuhiko Hayakawa, Haruka Tanabe, Keita Watanabe, Akari Nishida, Ikuo Kimura

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Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA by Nour Zeaiter, Laura Belot, Valérie Cunin, Roland Abi Nahed, Malgorzata Tokarska-Schlattner, Audrey Le Gouellec, Carlo Petosa, Saadi Khochbin, Uwe Schlattner

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Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development by Lynda Elghazi, Manuel Blandino-Rosano, Emilyn Alejandro, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi

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Editorial Board, cover figure description and credits

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Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice by Julia Leipner, Tsai-Sang Dederichs, Alexander von Ehr, Simon Rauterberg, Carolin Ehlert, Julian Merz, Bianca Dufner, Natalie Hoppe, Katja Krebs, Timo Heidt, Constantin von zur Muehlen, Peter Stachon, Klaus Ley, Dennis Wolf, Andreas Zirlik, Christoph Bode, Ingo Hilgendorf, Carmen Härdtner

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Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears by Robbert J. Van der Pijl, Weikang Ma, Christopher T.A. Lewis, Line Haar, Amalie Buhl, Gerrie P. Farman, Marcus Rhodehamel, Vivek P. Jani, O Lynne Nelson, Chengxin Zhang, Henk Granzier, Julien Ochala

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Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase by Yuanqing Gao, Andrés Vidal-Itriago, Irina Milanova, Nikita L. Korpel, Martin J. Kalsbeek, Robby Zachariah Tom, Andries Kalsbeek, Susanna M. Hofmann, Chun-Xia Yi

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Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice by Mikala M. Zelows, Corissa Cady, Nikitha Dharanipragada, Anna E. Mead, Zachary A. Kipp, Evelyn A. Bates, Venkateshwari Varadharajan, Rakhee Banerjee, Se-Hyung Park, Nathan R. Shelman, Harrison A. Clarke, Tara R. Hawkinson, Terrymar Medina, Ramon C. Sun, Todd A. Lydic, Terry D. Hinds, Jr., J. Mark Brown, Samir Softic, Gregory A. Graf, Robert N. Helsley

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Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling by Dries Bauters, Mathias Cobbaut, Lotte Geys, Johan Van Lint, Bianca Hemmeryckx, H. Roger Lijnen

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Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice by Patrick M. Schaefer, Jessica Huang, Arrienne Butic, Caroline Perry, Tal Yardeni, Wendy Tan, Ryan Morrow, Joseph A. Baur, Douglas C. Wallace

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Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area by Kuldeep Shrivastava, Thaarini Swaminathan, Alessandro Barlotta, Vikshar Athreya, Hassan Choudhry, Mark A. Rossi

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Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion by Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H. Chang, Jaehyung Cho, Brian N. Finck, Nicholas O. Davidson, Randal J. Kaufman

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Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice by Nicholas Douris, Bhavna N. Desai, ffolliott M. Fisher, Theodore Cisu, Alan J. Fowler, Eleen Zarebidaki, Ngoc Ly T. Nguyen, Donald A. Morgan, Timothy J. Bartness, Kamal Rahmouni, Jeffrey S. Flier, Eleftheria Maratos-Flier

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KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats by K.V. Andreassen, A.T. Larsen, N. Sonne, K.E. Mohamed, M.A. Karsdal, K. Henriksen

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