Antioxidant and phytochemical properties and in vitro cancer chemopreventive effects of averrhoa bilimbi l. extract on human breast and cervical adenocarcinoma by Yan, See Wan

“…Released of cytochrome c coupled with upregulation of caspase-3/7 and caspase-9 expression indicated that molecular mechanism in the induction of apoptosis by bilimbi on HeLa and MDA-MB-231 was through mitochondria-mediated intrinsic pathway, which also involve upregulation of pro-apoptotic Bax protein and downregulation of anti-apoptotic Bcl-2 protein. …”
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Inhibition of cell migration and invasion by miR-29a-3p in a colorectal cancer cell line through suppression of CDC42BPA mRNA expression by He, Pei Yuan, Yip, Wai Kien, Chai, Boon Lee, Chai, Boon Yean, Jabar, Mohd Faisal, Dusa, Noraini, Mohtarrudin, Norhafizah, Seow, Heng Fong

“…The objective of this study was to determine the effect of miR 29a 3p inhibitor on the migration and invasion of colorectal cancer cell lines (CRC) and the underlying molecular mechanisms. miR 29a 3p was detected using reverse transcription-quantitative polymerase chain reaction (RT qPCR) in the CRC cell lines HCT11, CaCo2, HT29, SW480 and SW620. …”
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Antiviral activity and mechanism of action of edible bird’s nest against influenza A virus strain A/Puerto Rico/8/1934 (H1N1) by Haghani, Amin

“…These natural extracts also have shown antiviral properties against influenza viruses; however, the molecular mechanism of action of these compounds still is not well characterized. …”
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Antioxidant activities, polyphenolic profile and chemopreventive properties of Cyphomandra betacea L. ethanolic extract on human breast and liver adenocarcinoma cells by Abdul Mutalib, Maisarah

“…Together with the released of cytochrome c, established that both extracts possibly induced apoptosis in HepG2 and MDA-MB-231 through the intrinsic pathway. The molecular mechanism in the induction of apoptosis by both extracts in HepG2 and MDA-MB-231 found that Bax protein was elevated with a concomitant down-regulation of Bcl-2 expression. …”
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Caspase-dependent apoptotic mechanism of gallic acid and its derivatives isolated from quercus infectoria ethyl acetate extract against cervical cancer cells lines (hela) by Ismail, Illyana

“…However, the antiproliferative activity and the underlying molecular mechanisms against human cancer cells have been poorly elucidated. …”
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Enterovirus-A71 exploits RAB11 to recruit chaperones for virus morphogenesis by Ng, Qing Yong, Mahendran, Vikneswari, Lim, Ze Qin, Tan, Jasmine Hwee Yee, Wong, Joel Jie Feng, Chu, Justin Jang Hann, Chow, Vincent T. K., Sze, Newman Siu Kwan, Alonso, Sylvie

“…Background: Enterovirus 71 (EV-A71) causes Hand, Foot and Mouth Disease (HFMD) in children and has been associated with neurological complications. The molecular mechanisms involved in EV-A71 pathogenesis have remained elusive. …”
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Interrogating structure-function relationships in the pathogenesis and treatment of human disease : insights into the development of therapeutics for emergent tropical viruses by Quinlan, Devin Scott

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Nanomechanics of cartilage at the matrix and molecular levels by Tavakoli Nia, Hadi

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Collective epithelial cell migration in response to two-dimensional geometrical extracellular matrix patterns by Xu, Hongmei

“…Healing of wavy stripes, however, involves gap bridging either via cell protrusion or by lamellipodium extension as critical cellular and molecular mechanisms in addition to purse-string contraction. …”
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Distinct roles of Tfap2A & Tfap2B in the diversification of GABAergic neuronal subtypes in the cerebellum by Norliyana Zainolabidin

“…To explore the molecular mechanisms underlying the development of cerebellar inhibitory neurons, we examined the involvement of Tfap2A and Tfap2B in the specification of cerebellar progenitors into distinct inhibitory neuronal subtypes in mice. …”
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Genome-wide search for quantitative trait loci (QTL) and genes for increased growth and improved fatty acid content in salt tolerant tilapia (oreochromis spp.) by Lin, Grace Xiulin

“…Nonetheless, this study lays the groundwork for further investigation of the molecular mechanisms and underlying cause of the phenotypic variation of these two traits. …”
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Suppression Effects of Pandanus Amarylfolius and Strobilanthes Cripus Extracts on the Growth of Breast Cancer Cells by Inducing p53-Mediated Apoptotic Pathway by Chong, Hueh Zan

“…Apoptosis induction was found to involve activation of caspase cascades and release of Cytochrome C. The molecular mechanisms in the induction of apoptosis by PA in MDA-MB-231 cells were found to involve upregulation of tumour suppressor protein p53 and pro-apoptotic bax protein while a reduction in the expression of inhibitor of apoptosis XIAP protein. …”
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Human fetal B-lymphopoiesis and acute lymphoblastic leukaemia: the impact of trisomy 21 by O'Byrne, S

“…</p> <p><strong>Aim:</strong> The aim of this project was to investigate the cellular and molecular mechanisms responsible for perturbed fetal B-lymphoid development in T21 and how this may contribute to ALL by addressing the following questions: 1. …”

Characterization of novel oil palm defense-related transcription factors during biotrophic and necrotrophic infection phases of Ganoderma boninense by Mohd Sakeh, Nurshafika

“…The fragmentary information on molecular interactions between plant and hemibiotroph should be explicated to identify the key molecular mechanisms of pathogenesis and plant immunity. …”
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Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance by Ledaki, I

“…Importantly, functional suppression of CAIX <em>in vitro</em> and <em>in vivo</em>, in two breast cancer cell lines resulted in the downregulation of breast cancer stem cell signatures, suggesting that CAIX is not just a marker of stemness but also a regulator of stemness.</p> <p>The molecular mechanism underlying the differential expression of CAIX in the two populations is not HIF-1α-dependent, but instead driven by hypoxia-induced reorganization of chromatin structure. …”

Identification of molecular pathways associated with Newcastle disease virus (AF2240) persistent infection in urothelial cell carcinoma by Ahmad, Umar

“…Moreover, the exact molecular mechanism by which UCC cells acquire NDV persistent infection has not been elucidated. …”
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The mouse visually evoked potential : neural correlates and functional applications by Muhammad, Rahmat

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Transcriptomic and carrageenan analysis under different light wavelenghts with carbon dioxide enrichment by Thien, Vun Yee

“…The findings of this project will contribute to our understanding of molecular mechanisms underlying light-induced responses in lower plants as well as facilitate our understanding in inorganic carbon fixation in red algae. …”
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