Four-membered heterocyclic molecules featuring boron and heavy group 14 elements that exhibit both σ-aromatic and π-aromatic properties: a new synthetic target by Zhang, Zheng-Feng, So, Cheuk-Wai, Su, Ming-Der

“…In this study, we present a series of theoretically designed B2G14G14' molecules, featuring four-membered-ring heterocycles containing boron and heavy group 14 elements (G14 and G14' = Si, Ge, Sn, and Pb). …”
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Part 1: Synthesis of vinyl sulfones via palladium-catalyzed sulfonylation of olefins. Part 2: Trienes : Synthesis via C-H Functionalization and as precursors to complex molecules. by Wang, Wee Jian.

“…Next in Part 2, we would like to present results from explorative studies on the synthesis of triene via C‒H functionalization and the transformation of trienes to complex molecules.…”
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Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses. by Fridkis-Hareli, M, Stern, J, Fugger, L, Strominger, J

“…In the present study various peptides, synthesized according to the binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to disease-associated HLA-DR2 (DRB1*1501) molecules. In particular, two peptides with residue K at position P-1, as referred to MBP 85-99, inhibited effectively the binding of both biotinylated MBP 85-99 and Cop 1 to HLA-DR2 molecules as well as IL-2 production by two MBP-specific HLA-DR2-restricted T-cell clones. …”

Use of complete eluted peptide sequence data from HLA-DR and -DQ molecules to predict T cell epitopes, and the influence of the nonbinding terminal regions of ligands in epitope selection. by Godkin, A, Davenport, M, Willis, A, Jewell, D, Hill, A

“…This suggests a possible role for these regions in determining ligands for HLA class II molecules. Thus, the use of complete eluted peptide sequence data offers a powerful approach to the prediction of HLA-DQ and -DR peptide ligands and T cell epitopes.…”

Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study. by Brili, S, Tousoulis, D, Antoniades, C, Vasiliadou, C, Karali, M, Papageorgiou, N, Ioakeimidis, N, Marinou, K, Stefanadi, E, Stefanadis, C

“…Endothelial function was evaluated in the right forearm by gauge-strain plethysmography, and serum levels of interleukin (IL)-1b, IL-6, soluble CD40 ligand (sCD40L), and soluble vascular cell adhesion molecule (sVCAM)-1 were determined by enzyme-linked immunosorbent assay. …”

Evaluation of Brønsted and Lewis acid sites in H-ZSM-5 and H-USY with or without metal modification using probe molecule-synchrotron X-ray powder diffraction by Lo, BTW, Lin, W-C, Li, MMJ, Day, S, Tang, C, Tsang, SCE

“…The adsorbate interactions of furans as probe molecules in H-ZSM-5 and H-USY with and without metal ion modification have been revealed by synchrotron X-ray powder diffraction (SXRD). …”

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes. by Hermansson, M, Sawaji, Y, Bolton, M, Alexander, S, Wallace, A, Begum, S, Wait, R, Saklatvala, J

“…Potential regulatory molecules novel to cartilage were identified; pro-inhibin betaA and processed inhibin betaA (which dimerizes to activin A) were produced by all the osteoarthritic samples and half of the normals. …”

Intrinsic folding properties of the HLA-B27 heavy chain revealed by single chain trimer versions of peptide-loaded class I major histocompatibility complex molecules by Lenart, I, Truong, L-H, Nguyen, DD, Rasiukienė, O, Tsao, E, Armstrong, J, Kumar, P, McHugh, K, Pereira, BI, Maan, BS, Garstka, MA, Bowness, P, Blake, N, Powis, SJ, Gould, K, Nesbeth, D, Antoniou, AN

“…We constructed a series of single chain trimeric molecules to determine the behaviour of the HLA-B27 HC in a scenario that usually allows for efficient MHC class I molecule folding. …”

A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo. by Palmowski, M, Parker, M, Choudhuri, K, Chiu, C, Callan, M, Van Der Merwe, P, Cerundolo, V, Gould, K

“…We have generated a construct encoding a single-chain H-2D(b) mouse MHC class I molecule in which an influenza virus nucleoprotein (NP) epitope, amino acid sequence ASNENMDAM, is fused to mouse beta(2)-microglobulin and the D(b) H chain via flexible linker sequences. …”

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. by Russell, A, Westwood, I, Crawford, M, Robinson, J, Kawamura, A, Redfield, C, Laurieri, N, Lowe, E, Davies, S, Sim, E

Frustrated Lewis pairs incorporating the bifunctional Lewis acid 1,1′-fc{B(C6F5)2}2: reactivity towards small molecules by Tirfoin, R, Gilbert, J, Kelly, MJ, Aldridge, S

Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. by Jackson, D, Bell, J

“…Transfected COS cells expressed a surface protein of Mr 46,000 that was similar to the native CD38 molecule expressed on the B cell line Daudi and the T cell leukemia HPB-ALL and which was recognized by each of the CD38 specific mAb HIT-2, T16, T168, HB7, 5D2, ICO-18, and ICO-20. …”

Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression (J. Immunol. (2010) 184 (6266-6274)) by Shi, C, Velázquez, P, Hohl, T, Leiner, I, Dustin, M, Pamer, E

Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. by Xue, L, Gyles, S, Wettey, F, Gazi, L, Townsend, E, Hunter, MG, Pettipher, R

“…It can stimulate vascular and other inflammatory responses by interaction with D prostanoid receptor (DP) and chemoattractant receptor-like molecule expressed on Th2 cells (CRTH2) receptors. …”

A distinct profile of six soluble adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin, L-selectin and P-selectin) in rheumatoid arthritis. by Littler, A, Buckley, C, Wordsworth, B, Collins, I, Martinson, J, Simmons, D

“…Thus, there is a distinct profile of soluble adhesion molecules in RA of which only sP-selectin correlates with disease activity.…”

Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. by Dustin, M, Rothlein, R, Bhan, A, Dinarello, C, Springer, T

Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecules. by Antrobus, R, Khan, N, Hislop, A, Montamat-Sicotte, D, Garner, L, Rickinson, AB, Moss, P, Willcox, B

“…Leukocyte immunoglobulin-like receptor-1 (LIR-1) is an inhibitory receptor that negatively regulates T cell effector functions after interaction with host class I major histocompatibility complex molecules and, additionally, binds to UL18, a human cytomegalovirus (HCMV)-encoded class I homologue. …”

Physical Electronics and Surface Physics by Gadzuk, J. W., Engelmaier, W., Stickney, Robert E., Fehrs, D. L., Lou, Y. S., Yamamoto, S.

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Symmetry principles in solid state and molecular physics/ by 272171 Lax, Melvin J.

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Molecular Beams by King, J. G.

Subjects: “…Search for a Small Charge Carried by Molecules…”
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