Nitric oxide and its important role in plant defence by Mohd Nasir, Nurul Najihah, Saidi, Noor Baity

“…Nitric oxide (NO) is a signaling molecule involved in numerous physiological processes in both animals and plants. …”
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CEACAM1 regulates TIM-3-mediated tolerance and exhaustion by Huang, Yu-Hwa, Zhu, Chen, Kondo, Yasuyuki, Anderson, Ana C., Gandhi, Amit, Russell, Andrew, Dougan, Stephanie K., Petersen, Britt-Sabina, Melum, Espen, Pertel, Thomas, Clayton, Kiera L., Raab, Monika, Chen, Qiang, Beauchemin, Nicole, Yazaki, Paul J., Pyzik, Michal, Ostrowski, Mario A., Glickman, Jonathan N., Rudd, Christopher E., Franke, Andre, Petsko, Gregory A., Kuchroo, Vijay K., Blumberg, Richard S., Ploegh, Hidde

“…Here we show that TIM-3 is co-expressed and forms a heterodimer with carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), another well-known molecule expressed on activated T cells and involved in T-cell inhibition[superscript 6, 7, 8, 9, 10]. …”
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An intercomparison of HO2 measurements by fluorescence assay by gas expansion and cavity ring-down spectroscopy within HIRAC (Highly Instrumented Reactor for Atmospheric Chemistry) by Onel, L, Brennan, A, Gianella, M, Ronnie, G, Aguila, A, Hancock, G, Whalley, L, Seakins, P, Ritchie, G, Heard, D

“…At 1000 mbar total pressure the correlation plot of [HO 2 ]FAGE versus [HO 2 ]CRDS gave an average gradient of 0.84±0.08 for HO 2 concentrations in the range ∼4-100×10 9 molecule cm -3 , while at 150 mbar total pressure the corresponding gradient was 0.90±0.12 on average for HO 2 concentrations in the range ∼6-750×10 8 molecule cm -3 . …”

An intercomparison of HO2 measurements by fluorescence assay by gas expansion and cavity ring–down spectroscopy within HIRAC (Highly Instrumented Reactor for Atmospheric Chemistry)... by Onel, L, Brennan, A, Gianella, M, Ronnie, G, Lawry Aguila, A, Hancock, G, Whalley, L, Seakins, P, Ritchie, G, Heard, D

“…At 1000 mbar total pressure the correlation plot of [HO2]FAGE versus [HO2]CRDS gave a gradient of 0.836 ± 0.004 for HO2 concentrations in the range ~ 4–100 × 109 molecule  cm−3 while at 150 mbar total pressure the corresponding gradient was 0.903 ± 0.002 for HO2 concentrations in the range ~ 6–750 × 108 molecule cm−3. …”

Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

In situ selective cellular nitric oxide sensing using humanized graphene film by Khoo, Si Yun.

“…Nitric oxide is a messenger molecule and plays important roles in maintaining physiological function. …”
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Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures by Zhang, Juan, Wang, Lihua, Pan, Dun, Song, Shiping, Boey, Freddy Yin Chiang, Zhang, Hua, Fan, Chunhai

“…A novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. …”
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4-Hydroxy-3-methoxybenzaldehyde-nicotinamide (1/1) by How, Fiona Ni Foong, M.S, Amalina, Khaledi, Hamid, Mohd Ali, Hapipah

“…In the title compound, C6H6N2O.C8H8O3, an equimolar cocrystal of nicotinamide and vanillin, the aromatic ring and the amide fragment of the nicotinamide molecule make a dihedral angle of 32.6 (2)deg. The vanillin molecule is almost planar, with an r.m.s. deviation for all non-H atoms of 0.0094 angstrom . …”
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Quantitative guidelines for force calibration through spectral analysis of magnetic tweezers data. by te Velthuis, A, Kerssemakers, J, Lipfert, J, Dekker, N

“…Single-molecule techniques are powerful tools that can be used to study the kinetics and mechanics of a variety of enzymes and their complexes. …”

Human DNA Cross-Link Repair 1A (DCLRE1A, SNM1A); A Target Enabling Package by Newman, J

“…Furthermore, we provide a crystallization system that generates thousands of reproducible crystals that allow soaking of small-molecule ligands. We provide crystal structures of several small molecule fragments and inhibitors, opening the way to development of more potent and selective inhibitors.…”

SpoIIIE mechanism of directional translocation involves target search coupled to sequence-dependent motor stimulation. by Cattoni, D, Chara, O, Godefroy, C, Margeat, E, Trigueros, S, Milhiet, P, Nöllmann, M

“…Using a new combination of ensemble and single-molecule methods, we dissect the series of steps required for SRS localization and motor activation. …”

Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues. by Gil-Sanz, C, Franco, S, Martinez-Garay, I, Espinosa, A, Harkins-Perry, S, Müller, U

“…Here, we show that CR cells express the immunoglobulin-like adhesion molecule nectin1, whereas neocortical projection neurons express its preferred binding partner, nectin3. …”

TRIATOM-TRIATOM COLLISIONS - FIXED ANGLE CLOSE-COUPLING STUDY OF VIBRATIONAL-EXCITATION IN THE CO-12(2)+CO-13(2) SYSTEM by Clary, D

“…A close-coupling approach to the calculation of quantal vibrational transition probabilities for the fixed angle scattering of a linear triatomic molecule with another linear triatomic molecule is described. …”

The crystal structure of human CD1b with a bound bacterial glycolipid. by Batuwangala, T, Shepherd, D, Gadola, S, Gibson, K, Zaccai, N, Fersht, A, Besra, G, Cerundolo, V, Jones, E

“…The human MHC class I-like molecule CD1b is distinctive among CD1 alleles in that it is capable of presenting a set of glycolipid species that show a very broad range of variation in the lengths of their acyl chains. …”

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain by Aprile, F, Dhulesia, A, Stengel, F, Roodveldt, C, Benesch, J, Tortora, P, Robinson, C, Salvatella, X, Dobson, C, Cremades, N

“…Our results show that Hsp70 oligomerization takes place through a specific interaction between the interdomain linker of one molecule and the substrate-binding domain of a different molecule, generating dimers and higher-order oligomers. …”

Organic solar cells based on a novel infrared absorbing aza-bodipy dye by Mueller, T, Gresser, R, Leo, K, Riede, M

“…However, in particular for small molecule based cells, efficient infrared absorbers are still rare. …”

Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. by Fish, P, Filippakopoulos, P, Bish, G, Brennan, P, Bunnage, M, Cook, A, Federov, O, Gerstenberger, B, Jones, H, Knapp, S, Marsden, B, Nocka, K, Owen, DR, Philpott, M, Picaud, S, Primiano, M, Ralph, M, Sciammetta, N, Trzupek, J

“…Herein, we describe the discovery and structure-activity relationship (SAR) of a novel, small-molecule chemical probe for BET family inhibition that was identified through the application of structure-based fragment assessment and optimization techniques. …”

Probing the location of the unpaired electron in spin-orbit excited collisions of NO with Ar by Heid, C, Bentham, IP, Walpole, V, Gheorghe, R, Jambrina, PG, Aoiz, FJ, Brouard, M

“…In addition, a prominent forward scattered feature is observed for intermediate, even rotational transitions when the atom approaches the molecule from the O-end. The appearance of this peak originates from an attractive well on the A' potential energy surface, which efficiently directs high impact parameter trajectories towards the region of high unpaired electron density near the N-end of the molecule. …”

Field-effect control of graphene-fullerene thermoelectric nanodevices by Gehring, P, Harzheim, A, Spiece, J, Sheng, Y, Rogers, G, Evangeli, C, Mishra, A, Robinson, B, Porfyrakis, K, Warner, J, Kolosov, O, Briggs, G, Mol, J

“…Although it was demonstrated that discrete molecular levels determine the sign and magnitude of the thermoelectric effect in single-molecule junctions, full electrostatic control of these levels has not been achieved to date. …”

The retinoid agonist Tazarotene promotes angiogenesis and wound healing by Al Haj Zen, A, Nawrot, DA, Howarth, AL, Caporali, A, Ebner, D, Vernet, A, Schneider, JE, Bhattacharya, S

“…Therapeutic angiogenesis is a major goal of regenerative medicine, but no clinically approved small molecule exists that enhances new blood vessel formation. …”