Simultaneous, Large Multi-Gene Delivery for Implementation of Fluorescent Reporter Spatial Multiplexing to Image Signaling Pathways by Johnson, Shannon L.

“…However, the problem with spectral multiplexing is the large degree of spectral overlap from the broad shape of the reporter’s spectrum that leads to a blended signal masking which data belongs to which molecule. This dissertation describes the concept of spatial multiplexing to circumvent the limitations of spectral multiplexing, the challenges of designing a system to deliver multiple reporters simultaneously in culture, and the attempt to teach resilience in developing tools for understanding the nervous system in a 14-week course. …”
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Investigations of Iron–Nitrogen Bonding at Synthetic Iron–Sulfur Clusters by Sridharan, Arun

“…A combined spectroscopic and theoretical analysis of this redox series using variable-temperature 1H nuclear magnetic resonance spectroscopy reveals that oxidation events are primarily centered at the imido fragment, which takes on an iminyl ([NAr]•−) or triplet nitrene ([NAr]2•) configuration depending on the charge state of the molecule. Two-electron oxidation of [Fe4S4]+ anilido complexes results in formal aminyl radical reductive elimination, generating aniline, hydrazine, and/or azoarene as byproducts along with the corresponding [Fe4S4]2+ solvento adduct. …”
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Similarity Metrics for Biological Data: Algorithmic developments for high-dimensional datasets by Narayan, Ashwin

“…Every cell in the sample can be individually profiled — the amount of each type of protein or metabolite or other molecule of interest can be counted. Understanding the molecular basis that determines the differentiation of cell fates is thus the holy grail promised by these data. …”
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High throughput measurement and perturbation of tissues and tissue-derived cellular models by Kummerlowe, Conner Samuel

“…First, tools for comprehensively measuring tissues– such as single-cell RNA-sequencing (scRNA-seq)- can identify the disruptions to the molecules, pathways, and cells in a tissue that are correlated with disease. …”
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Exciton Dynamics in DNA-Chromophore Assemblies by Hart, Stephanie M.

“…Through a sequence- dependent mechanical force induced by the surrounding DNA, we demonstrate that distortions can be used to construct a toolkit of fluorophores visible at the single-molecule level, suggesting potential use as an imaging probe. …”
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Engineering plant-microbe communication for synthetic symbioses by Toth, Tyler Daniel

“…To the best of our knowledge, this is the first demonstration of engineered microbe-to-plant communication using a small molecule. We were also able to place the biosynthesis of pC-HSL under the control of various sensors and use an engineered consortium to perform logical operations on multiple environmental inputs. …”
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Recording and Reprogramming Neuroimmunity in Cancer by Tabet, Anthony

“…These therapies, which include the small molecule chemotherapies carmustine and temozolimide, photodynamic therapy, tumor-treating fields and others, attempt to treat brain tumors by disrupting processes important for proliferation of cancer cells. …”
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DNA as grabbers and steerers of quantum emitters by Cho, YongDeok, Park, Sung Hun, Huh, Ji-Hyeok, Gopinath, Ashwin, Lee, Seungwoo

“…A collective set of exotic characteristics of DNA molecules, including Watson-Crick complementarity and helical morphology, enables reliable grabbing of quantum emitters at the on-demand position and steering of their directors at the single molecular level. …”
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Rapid prediction of conformationally-dependent DFT-level descriptors using graph neural networks for carboxylic acids and alkyl amines by Haas, Brittany C, Hardy, Melissa A, Sowndarya S. V., Shree, Adams, Keir, Coley, Connor W, Paton, Robert S, Sigman, Matthew S

“…Employing 2D and 3D graph neural network architectures trained on these libraries culminated in the development of predictive models for molecule-level descriptors, as well as the bond- and atom-level descriptors for the conserved reactive site (carboxylic acid or amine). …”
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Case studies in the modeling and control of continuous pharmaceutical manufacturing processes by Maloney, Andrew John

“…The pharmaceutical industry employs a myriad of modalities; ranging from small molecules to biologics such as peptides, monoclonal antibodies, bi-specific antibodies, and viral vectors. …”
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Spectroscopy and external control of optical dynamics in single semiconductor nanocrystals by Shimizu, Kentaro, 1975-

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Vibrational Kerr spectroscopy by Janni, James A. (James Alan), 1970-

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Systematic Conformational Search with Constraint Satisfaction by Tucker-Kellogg, Lisa

“…Throughout biological, chemical, and pharmaceutical research,conformational searches are used to explore the possiblethree-dimensional configurations of molecules. This thesis describesa new systematic method for conformational search, including anapplication of the method to determining the structure of a peptidevia solid-state NMR spectroscopy. …”
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Enantioselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes. Synthesis of amphidinolides T1 and T4 via catalytic, stereoselective macrocyclizations by Colby Davie, Elizabeth A. (Elizabeth Anne)

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Development of enclosed life support system for underground rescue employing a photocatalytic metal oxide thin film to generate oxygen from water and reduce carbon dioxide by Trivedi, Meghna S

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Pulsed field separation of biomolecules in a nanofluidic filter array by Reyes González, Noel I. (Noel Iván)

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Efficient numerical algorithms for surface formulations of mathematical models for biomolecule analysis and design by Bardhan, Jaydeep Porter, 1978-

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Regression analysis of oncology drug licensing deal values by Hawkins, Paul Allen

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The Hob system for verifying software design properties by Lam, Patrick, Ph. D. Massachusetts Institute of Technology

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Tackling the bigger picture in computational drug design : theory, methods, and application to HIV-1 protease and erythropoietin systems by Radhakrishnan, Mala Lakshmi

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