Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging by Zhao, Yanli, Zhang, Huacheng, Ma, Xing, Nguyen, Kim Truc, Zeng, Yongfei, Tai, Shuhui

“…When a fluorescent guest molecule, bipyridinium derivative 3, was added into the suspensions of the hybrids, the suspensions of 1-GO and 2-GO were as stable as the original. …”
Get full text
Get full text

The toxicity of amyloid ß oligomers by Zhao, Li Na, Long, Hon Wai, Mu, Yuguang, Chew, Lock Yue

“…We further illustrate that the molecule curcumin is a potential Aβ toxicity inhibitor as a β-sheet breaker by having a high propensity to interact with certain Aβ residues without binding to them. …”
Get full text
Get full text

First principles molecular dynamics study of filled ice hydrogen hydrate by Zhang, Jingyun, Kuo, Jer-Lai, Iitaka, Toshiaki

“…In the case of rare gas hydrate, there would be no guest molecules’ rotation-nonrotation transition since the guest molecules keep their spherical symmetry at any temperature. …”
Get full text
Get full text

Variations of subunit ε of the mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207 by Rao, Srinivasa P. S., Biuković, Goran, Basak, Sandip, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Roessle, Manfred, Dick, Thomas, Hunke, Cornelia, Grüber, Gerhard

“…T19 and R37 of ε provide the necessary polar interactions with the drug molecule. This new model of the mechanism of TMC207 provides the basis for the design of new drugs targeting the F1FO ATP synthase in M. tuberculosis.…”
Get full text
Get full text

How Is a metabolic intermediate formed in the mechanism-based inactivation of cytochrome P450 by using 1,1-dimethylhydrazine : hydrogen abstraction or nitrogen oxidation? by Hirao, Hajime, Chuanprasit, Pratanphorn, Cheong, Ying Yi, Wang, Xiaoqing

“…Hydrazines are among the molecules that act as mechanism-based inactivators to terminate the function of P450s, which are essential heme enzymes responsible for drug metabolism in the human body. …”
Get full text
Get full text

Visible light induced hole transport from sensitizer to Co3O4 water oxidation catalyst across nanoscale silica barrier with embedded molecular wires by Agiral, Anil, Soo, Han Sen, Frei, Heinz

“…Spherical Co3O4(4 nm)–SiO2(2 nm) core–shell nanoparticles with p-oligo(phenylenevinylene) wire molecules (three aryl units, PV3) cast into the silica were developed to establish proof of concept for charge transport across the embedded wire molecules. …”
Get full text
Get full text

The relationship between vitamin B6, diabetes and cancer by Merigliano, Chiara, Mascolo, Elisa, Burla, Romina, Saggio, Isabella, Vernì, Fiammetta

“…Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule. PLP deficiency has been associated to many human pathologies including cancer and diabetes and the mechanism behind this connection is now becoming clearer. …”
Get full text
Get full text

Evaluating the binding efficiency of pheromone binding protein with its natural ligand using molecular docking and fluorescence analysis by Ilayaraja, Renganathan, Rajkumar, Ramalingam, Rajesh, Durairaj, Muralidharan, Arumugam Ramachandran, Padmanabhan, Parasuraman, Archunan, Govindaraju

“…In the present study, an attempt has been made through computational method to evaluating the binding efficiency of α2u with the natural ligand (farnesol) and standard fluorescent molecule (2-naphthol). The docking analysis revealed that the binding energy of farnesol and 2-naphthol was almost equal and likely to share some binding pocket of protein. …”
Get full text
Get full text

Accumulation and enhanced cycling of polyphosphate by Sargasso Sea plankton in response to low phosphorus by Martin, Patrick, Dyhrman, Sonya T., Lomas, Michael W., Poulton, Nicole J., Van Mooy, Benjamin A. S.

“…In a survey of phytoplankton phosphorus stress in the western North Atlantic, we found that phytoplankton in the phosphorus-depleted subtropical Sargasso Sea were enriched in the biochemical polyphosphate (polyP) compared with nutrient-rich temperate waters, contradicting the canonical oceanographic view of polyP as a luxury phosphorus storage molecule. The enrichment in polyP coincided with enhanced alkaline phosphatase activity and substitution of sulfolipids for phospholipids, which are both indicators of phosphorus stress. …”
Get full text
Get full text

Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells by Kim, Seong-Hoon, Ryu, Hye Guk, Lee, Juhyun, Shin, Joon, Harikishore, Amaravadhi, Jung, Hoe-Youn, Kim, Ye Seul, Lyu, Ha-Na, Oh, Eunji, Baek, Nam-In, Choi, Kwan-Yong, Yoon, Ho Sup, Kim, Kyong-Tai

“…Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival. …”
Get full text
Get full text

Insight into proton transfer in phosphotungstic acid functionalized mesoporous silica-based proton exchange membrane fuel cells by Zhou, Yuhua, Yang, Jing, Su, Haibin, Zeng, Jie, Jiang, San Ping, Goddard, William A

“…When the adjacent HPWs are close (less than 17.0 Å apart), the calculated activation energy for intramolecular proton transfer within a HPW molecule is higher (29.1–18.8 kJ/mol) than the barrier for intermolecular proton transfer along the hydrogen bond. …”
Get full text
Get full text

Antimicrobial effects of helix D-derived peptides of human antithrombin III by Papareddy, Praveen, Kalle, Martina, Bhongir, Ravi KV, Mӧrgelin, Matthias, Malmsten, Martin, Schmidtchen, Artur

“…In contrast to intact ATIII, the results showed that extensive degradation of the molecule yielded fragments with antimicrobial activity. …”
Get full text
Get full text

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction by Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Hyvönen, Marko, Spring, David R., Verma, Chandra Shekhar

“…The discovery of new Protein–Protein Interaction (PPI) modulators is currently limited by the difficulties associated with the design and synthesis of selective small molecule inhibitors. Peptides are a potential solution for disrupting PPIs; however, they typically suffer from poor stability in vivo and limited tissue penetration hampering their wide spread use as new chemical biology tools and potential therapeutics. …”
Get full text
Get full text

Identification of a new chemical class of antimalarials by Bozdech, Zbynek, Brunner, Ralf, Aissaoui, Hamed, Brun, Reto, Corminboeuf, Olivier, Delahaye, Stephane, Fischli, Christoph, Boss, Christoph, Heidmann, Bibia, Kaiser, Marcel, Kamber, Jolanda, Meyer, Solange, Papastogiannidis, Petros, Siegrist, Romain, Voss, Till, Welford, Richard, Wittlin, Sergio, Binkert, Christoph

“…Here, we describe a compound representative of a new class of antimalarials. This molecule, ACT-213615, potently inhibits in vitro erythrocytic growth of all tested Plasmodium falciparum strains, irrespective of their drug resistance properties, with half-maximal inhibitory concentration (IC50) values in the low single-digit nanomolar range. …”
Get full text
Get full text

Multiple diguanylate cyclase-coordinated regulation of pyoverdine synthesis in P seudomonas aeruginosa by Yam, Joey Kuok Hoong, Liu, Yang, Chua, Song Lin, Givskov, Michael, Nielsen, Thomas E., Tolker-Nielsen, Tim, Cao, Bin, Yang, Liang, Chen, Yicai, Yuan, Mingjun, Mohanty, Anee

“…The nucleotide signalling molecule bis-(3'-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) plays an essential role in regulating microbial virulence and biofilm formation. …”
Get full text
Get full text
Get full text

Bismuth vacancy mediated single unit cell Bi2WO6 nanosheets for boosting photocatalytic oxygen evolution by Di, Jun, Chen, Chao, Zhu, Chao, Ji, Mengxia, Xia, Jiexiang, Yan, Cheng, Hao, Wei, Li, Shuzhou, Li, Huaming, Liu, Zheng

“…Moreover, the bismuth vacancy structure benefit for the surface adsorption and activation of water molecule, which favors the water oxidation reactions. …”
Get full text

Synthetic biohybrid peptidoglycan oligomers enable pan-bacteria-specific labeling and imaging : in vitro and in vivo by He Jing-Xi, Hoang, Kim Le Mai, Kho, Shu Hui, Guo, Zhong, Zhong, Wenbin, Thappeta, Kishore Reddy Venkata, Zamudio-Vázquez, Rubi, Hoo, Sin Ni, Xiong, Qirong, Duan, Hongwei, Yang, Liang, Chan-Park, Mary Bee Eng, Liu, Xue-Wei

“…Over the past two decades, small-molecule-based labeling agents, such as antibiotics, D-amino acids or monosaccharides have been developed for probing biological processes in bacteria. …”
Get full text

Lysosome-assisted mitochondrial targeting nanoprobe based on dye-modified upconversion nanophosphors for ratiometric imaging of mitochondrial hydrogen sulfide by Li, Xiang, Zhao, Hui, Ji, Yu, Yin, Chao, Li, Jie, Yang, Zhen, Tang, Yufu, Zhang, Qichun, Fan, Quli, Huang, Wei

“…However, these cationic small molecule probes are inapplicable for in vivo imaging because of the shallow tissue penetration and poor biostability. …”
Get full text

Study of carbon nanotubes for molecular electronic applications by Zhang, Qing

“…In contrast, molecular electronic devices can, in principle, overcome these problems, because it is possible to have single-molecule devices that are organized cheaply in parallel self-assembly. …”
Get full text

Diketopyrrolopyrrole based organic semiconductors with different numbers of thiophene units : symmetry tuning effect on electronic devices by Liu, Qian, Surendran, Abhijith, Feron, Krishna, Manzhos, Sergei, Jiao, Xuechen, McNeill, Christopher R., Bottle, Steven E., Bell, John, Leong, Wei Lin, Sonar, Prashant

“…These small molecules exhibit promising charge carrier mobility and behave as p-type semiconductors. …”
Get full text