Cancer therapeutic study utilizing fluorescent bioimaging probe targeting tumor initiating cells by Tan, Corrina Zi Ting, n

“…Therefore, in this study, we are looking at a previously discovered small molecule probe specific for lung cancer TICs, TiNIR (Tumor Initiating cell probe with Near InfraRed), TiNIR binds to HMOX2 intracellularly, allowing us to identify TICs via its fluorescence signal. …”
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Research advance of natural products in tumor immunotherapy by Huo, Jin-Ling, Fu, Wen-Jia, Liu, Zheng-Han, Lu, Nan, Jia, Xiang-Qian, Liu, Zhang-Suo

“…In this review, we describe current advances in employing natural products and natural small-molecule drugs targeting immune cells to avoid tumor immune escape, which may bring some insight for guiding tumor treatment.…”
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Effective surface modification of 2D MXene toward thermal energy conversion and management by Bark, Hyunwoo, Thangavel, Gurunathan, Liu, Rui Jun, Chua, Daniel H. C., Lee, Pooi See

“…First, this work discusses the current progress in the surface modification of 2D MXenes, including termination with functional groups, small-molecule organic compound functionalization, and polymer modification and composites. …”
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Unveiling charge-transfer dynamics at singlet fission layer/hybrid perovskite interface by Xiao, Xingchi, Cheng, Liang, Bao, Di, Tan, Qi Ying, Salim, Teddy, Soci, Cesare, Chia, Elbert E. M., Lam, Yeng Ming

“…In this work, we attempt to elucidate the charge dynamics of an SF/perovskite system by incorporating a well-known SF molecule, TIPS-pentacene, and a triple-cation perovskite Cs0.05(FA0.85MA0.15)0.95PbI2.55Br0.45, owing to their well-matched energy structures. …”
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Exploring Raman spectroscopy for developing prototypes in nanopore DNA sequencing by See, Josephine Si Yu

“…This technology's ability to directly read DNA molecules reduces the potential for errors associated with sample preparation. …”
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Optical nonlinearity in graphene coated hollow-core fibers by Goh, Zhi Ping

“…However, those gas molecules constrain thermal dynamics, ionization, pressure maintaining as well as lacking of optical nonlinear susceptibility χ(2). …”
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Where data science meets surface-enhanced Raman Scattering: Harnessing fingerprint variations to drive practical sensing applications by Leong, Yong Xiang

“…This thesis explores its application in surface-enhanced Raman scattering (SERS), a powerful spectroscopic technique that offers molecule-specific readout with high sensitivity. Despite having immense potential, practical SERS sensing applications remains hindered by poor surface affinities of the target analytes and complexity of the media they are present within. …”
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pH-assisted multichannel heat shock monitoring in the endoplasmic reticulum with a pyridinium fluorophore by Chakraborty, Sandip, Bindra, Anivind Kaur, Thomas, Anagha, Zhao, Yanli, Ajayaghosh, Ayyappanpillai

“…In this report, we have demonstrated the use of a pyridinium-based fluorescent molecule, PM-ER-OH, as a ‘multichannel’ imaging probe to monitor the pH change associated with a heat shock in the endoplasmic reticulum. …”
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Isolable spirocyclic silylone: π-delocalized spiro[3.3]heptasila-2,6-diylidone by Wee, Meldon Yi-Shuo, Quek, Shina, Wu, Chi-Shiun, Su, Ming-Der, So, Cheuk-Wai

“…Connecting two cyclic tetrylone rings through a single shared quaternary group 14 element atom to form a spirocyclic molecule has been unexplored both theoretically and experimentally. …”
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Concentration-driven evolution of adaptive artificial ion channels or nanopores with specific anticancer activities by Chen, Zhiqing, Xie, Xiaopan, Jia, Chunyan, Zhong, Qishuo, Zhang, Qiuping, Luo, Daoxin, Cao, Yin, Mu, Yuguang, Ren, Changliang

“…Herein, we report on a novel class of adaptive artificial channels, Pn-TPPs, based on PEGylated cholic acids bearing triphenylphosphonium (TPP) groups as anion binding motifs. Interestingly, the molecules self-assemble into chloride ion channels at low concentrations while transforming into small molecule-permeable nanopores at high concentrations. …”
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In-situ activation of biomimetic single-site bioorthogonal nanozyme for tumor-specific combination therapy by Ma, Mengmeng, Yuan, Wei, Zhong, Wenbin, Cheng, Yu, Yao, Haochen, Zhao, Yanli

“…Cu/Ce-MOF@M favors a 32.1-fold higher catalytic activity than the widely used MOF-supported copper nanoparticles at single-particle level, as first evidenced by single-molecule fluorescence microscopy. Furthermore, with cancer cell-membrane camouflage, Cu/Ce-MOF@M demonstrates preferential tropism for its parent cells. …”
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Robust catalytic SEAr H/D exchange of arenes with D2O: metal-free deuteration of natural complexes and drugs by Zhang, Zhenguo, Lv, Yongheng, Ong, Renee Wan Qing, Zhao, Xuefei, Jia, Zhenhua, Loh, Teck-Peng

“…This metal-free protocol employs a triaryl carbenium as the mediator and showcases a wide applicability in the late-stage deuteration of various natural products and small-molecule drugs. Gram-scale deuteration was successfully demonstrated with β-Estradiol, highlighting the method's practicability. …”
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Investigating the roles of cytoplasmic proteins talin and kindlin3 in integrin LFA-1 activation by Li, Yan Feng

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Maintenance and expansion of hematopoietic stem cells in vitro using genetic methods by Wu, Zhihao

“…Inhibition of this pathway using small molecule AhR inhibitor in combination with cytokine cocktail allowed 30-100 fold expansion of HSC in vitro. …”
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Characterization of kindlin3 in Integrin functions by Feng, Chen

“…Integrins are heterodimeric cell adhesion molecules that are involved in many biological processes. …”
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Development of quorum-sensing-based genetic circuits that enable programmable functionalities in escherichia coli by Tan, Mui Hua

“…Bacteria communicate by releasing and detecting the intercellular signalling molecules called autoinducers. As the population density increases, the concentration of autoinducers increases correspondingly. …”
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Unravelling the roles of non-Watson-Crick and triplex structures in regulating RNA folding dynamics and function by Zhong, Zhensheng

“…The ensemble thermal denaturation of the hairpins shows a 3-state pathway with an on-pathway intermediate with the disruption of the non-canonical base paired region as well as two apical Watson-Crick base pairs. In single molecule force spectroscopic studies, a misfolded hairpin at forces below 13 pN is observed. …”
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Morphology dependent photophysics in bulk heterojunction organic solar cells by Solanki, Ankur

“…Similar to conjugated polymer systems, the suppression of charge carrier losses is also important in solution processed small molecule blend system. Solvent vapour annealing of DRCN5T:PCBM active blend layer helps to reduce the predominant monomolecular recombination in the finely mixed system. …”
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Investigating the role of kindlin-3 in protein translation and tumorigenesis via interaction with RACK1 by Qu, Jing

“…Kindlins modulate cell-cell and cell-Extracellular Matrix (ECM) interaction by regulating the ligand-binding affinity and avidity of the cell surface adhesion molecules-integrins. Kindlin-3 stabilizes β1, β2 and β3 integrins-mediated cell adhesion. …”
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Characterisation of DODAC lamellar gel phase in the presence of additives by Steven

“…This is due to its lamellar phases that has excellent conditioning benefits, with the liquid crystalline phase (Lα) existing above gel melting temperature (Tm) of around 45 oC, which has good swelling potential for molecule delivery. However, the typical usage at room temperature proves this Tm to limit its applicability, and it causes the need to use additives that maintain the structure and tune its Tm for optimum usage, which in the past were mostly studied on zwitterionic and nonionic surfactants. …”
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