Molecularly targeted therapies for asthma: current development, challenges and potential clinical translation by Sulaiman, Ibrahim, Lim, Jonathan Chee Woei, Soo, Hon Liong, Stanslas, Johnson

“…Clinical trials revealed the safety and effectiveness of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists such as OC0000459, BI-671800 and ARRY-502 in the restoration of Th1/Th2 balance. …”
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Di-l-methacrylato-j4O:O0-bis[aquabis(1,10-phenanthroline-j2N,N0)-copper(II)] dinitrate dihydrate by Tarafder, Md. Tofazzal Hossain, Reza, M. Y., Crouse, Karen Anne, Suchada, Chantrapromm, Fun, Hoong Kun

“…The title complex, [Cu2(C4H5O2)2(C12H8N2)2(H2O)2](NO3)2- 2H2O, contains a dimeric [Cu2(C4H5O2)2(C12H8N2)2- (H2O)2]2+ dication with two five-coordinated CuII ions linked by two methacrylate ions in a syn–syn bridging arrangement.The dication possesses pseudo-twofold rotational symmetry.The pentacoordination of each CuII ion has a distorted squarepyramidal geometry, with two N donors from a phenanthroline ligand and two carboxylate O atoms occupying basal sites and the apical position being occupied by a water molecule. In the crystal packing, molecules are linked to form a threedimensional framework by O—H O and C—H O hydrogen bonds and – interactions [centroid–centroid distances of 3.6039 (15), 3.5301 (15), 3.6015 (15),3.6496 (15) and 3.6858 (15) A ° ].…”
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Experimental review on the Substance P-enhanced endothelial permeability in human umbilical vein endothelial cells (HUVECS) by N. N. H., Khairudin, Z., Nurfarahdilla, Ng, Chin Theng, Fong, Lai Yen, Perimal, Noch Kumar, A., Zuraini, Abdullah, Muhammad Nazrul Hakim

“…FITC-Dextran were finally added to cell culture inserts for 5 minutes to let the fluorescence molecule pass through the gaps. Endothelial permeability is directly proportional with extravasation of FITC-Dextran, determined by fluorescence intensity reading. …”
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Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives by Aluwi, Mohd Fadhlizil Fasihi Mohd, Rullah, Kamal, Haque, Md. Areeful, Yamin, Bohari M., Ahmad, Waqas, Amjad, Muhammad Wahab, Leong, Sze Wei, Fahmizar, Nurul Amira, Jalil, Juriyati, Abas, Faridah, Ismail, Nor Hadiani, Jantan, Ibrahim, Kok, Wai Lam

“…Curcumin is an important molecule found in turmeric plants and has been reported to exhibit some profound anti-inflammatory activities by interacting with several important molecular targets found in the mitogen-activated protein kinase and NF-κβ pathways. …”
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TILLING, high-resolution melting (HRM), and next-generation sequencing (NGS) techniques in plant mutation breeding by Taheri, Sima, Abdullah, Thohirah Lee, Jain, Shri, Sahebi, Mahbod, Azizi, Parisa

“…Impressive progress in next-generation sequencing (NGS) technologies has paved the way for the detection and exploitation of genetic variation in a given DNA or RNA molecule. This review discusses the applications of TILLING in combination with HRM and NGS technologies for screening of induced mutations and discovering SNPs in mutation breeding programs.…”
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Label-free binding analysis of 4-(2-Pyridylazo)-resorcinol-based composite layer with cobalt ion using surface plasmon resonance optical sensor by Saleviter, Silvan, Yap, Wing Fen, Sheh Omar, Nur Alia, Mohd Daniyal, Wan Mohd Ebtisyam Mustaqim, Abdullah, Jaafar, Mahdi, Mohd Adzir

“…Label-free measurements of small-molecule binding interactions are of high interest to researchers across multiple scientific disciplines. …”
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Ni(II) complex containing a thiosemicarbazone ligand: synthesis, spectroscopy, single-crystal X-ray crystallographic and conductivity studies by M. Osman, Uwaisulqarni, Silvarajoo, Sharmili, Kamarudin, Khadijah H., Mohamed Tahir, Mohamed Ibrahim, Kwong, Huey Chong

“…In addition, the structure of LH ligand presented a thione form and the molecule has crystallized in triclinic crystal system with Pī space group. …”

Synthesis and Surfactant Properties of Alpha-Sulfonated Polyhydric Alcohol Ester (ASPA) by Ahmed Nur, Adam Ibrahim

“…The presences of CH20H and CHOH groups of ASPA molecule via SME were indicated by peak 8 at 3.6 and 3.7 ppm respectively in 1 H-NMR spectrum. …”
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A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mi... by Tham, Chau Ling, Sin, Yee Yeoh, Ong, Chun Hao, Harith, Hanis Hazeera, Israf Ali, Daud Ahmad

“…These findings demonstrate that BHMC, a synthetic nonsteroidal small molecule, ameliorates acute airway inflammation associated with allergic asthma, primarily by suppressing the release of inflammatory mediators and goblet cell hyperplasia to a lesser extent in acute airway inflammation of allergic asthma.…”

Facile green synthesis of fingernails derived carbon quantum dots for Cu2sensing and photodegradation of 2,4-dichlorophenol by Tai, Jun Yan, Leong, Kah Hon, Saravanan, Pichiah, Tan, Sin Tee, Chong, Woon Chan, Sim, Lan Ching

“…It also served as electron reservoir for the reduction of oxygen molecule to produce superoxide anion radical (radical dotO2−). …”

Three closely related (2E,200E)-3,300-(1,4-phenylene)- bis[1-(methoxyphenyl)prop-2-en-1-ones]: supramolecular assemblies in one dimension mediated by hydrogen bonding and C—Hp int... by Aijia, Sim, Chidan Kumar, C. S., Huey, Chong Kwong, Li, Yee Then, Win, Yip Foo, Ching, Kheng Quah, Naveen, S., Chandraju, S., Lokanath, N. K., Warad, Ismail

“…In the crystal of (I), molecules are linked by pairs of C—H interactions into chains running parallel to [101]. …”
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A Marine Actinomycete Rescues Caenorhabditis elegans from Pseudomonas aeruginosa Infection through Restitution of Lysozyme 7 by Fatin, Siti N., Tan, Boon Khai, Chong, Alexander Shu Chien, Khairuddean, Melati, Abdullah, Amirul AI-Ashraf

“…In lys-7::GFP worms, this partition was shown to induce the expression of lysozyme 7, an important innate immunity defense molecule that was repressed during PA14 infection. …”
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Crystal structure of tetraaquabis(3,5-diamino- 4H-1,2,4-triazol-1-ium)cobalt(II) bis[bis(pyridine-2,6-dicarboxylato)- cobaltate(II)] dihydrate by Johnson, Atim, Mbonu, Justina, Hussain, Zahid, Loh, Wan Sin, Fun, Hoong Kun

“…The asymmetric unit of the title compound, [Co(C2H6N5)2- (H2O)4][Co(C7H3NO4)2]2�2H2O, features 1.5 CoII ions (one anionic complex and one half cationic complex) and one water molecule. In the cationic complex, the CoII atom is located on an inversion centre and is coordinated by two triazolium cations and four water molecules, adopting an octahedral geometry where the N atoms of the two triazolium cations occupy the axial positions and the O atoms of the four water molecules the equatorial positions. …”
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Effect Of Fiber Composition On Mechanical And Physical Properties Of High Loading Wood Fiber Composites by Ashari, Aminullah

“…SD-PP composite (without MAPP) experience drop in tensile modulus about 46 % and the drop of mechanical properties is due to the photo-oxidation and chain scission of the polymer molecule. The degradation of specimens after 1000 hours exposure Xenon-arc light was also proven by colour change analysis where it is found that all samples lost most of it original colour…”
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Adhesion Performance Of Solvent-Based Adhesive In Medical Tube by Ghazali, Muhammad Faris Afdhal

“…The ratios between polymer and solvent also are important as the inter-diffusion of adherend and adhesive depends on the interaction between substrate molecule and adhesive layer. This study highlighted the influence of formulations and processing parameter onto its adhesion performance.…”
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Targeting Regulatory Pathways Of Stim1 In Nasopharyngeal Cancer by Imakwu, Okekpa Simon

“…Stromal interaction molecule 1 (STIM1) is involved in various carcinogenic processes. …”
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Immune regulation of autoimmune diabetes: the role of regulatory t(t-reg) cells & ppar gamma by Nor, Norazmi Mohd

“…Another anti-inflammatory molecule, peroxisome proliferatoractivated receptory (PPARyfflhas also been previously shown to have immunoregulatory properties. …”
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Fabrication of water filter using silica powder from rice husk waste product under compaction method by Muslem, Muhammad Firdaus, Ahmad, Sufizar, Isamudin, Ikhwan, Abd Rahman, Hamimah, Mahzan, Shahruddin, Azmi, Mohd Azham, Ismail, Azzura, Sufi, Syahmie

“…Ceramic water filtration is the method of filtering water using a porous ceramic medium to remove contaminants or germs and also the pore size of the ceramic water filter is small enough to catch anything larger than a water molecule, including bacteria. By producing silica water filter from rice husk for the use in water filter can help to purify the water and remove unwanted substance from the water. …”
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Characterization and treatment of titanium dioxide, TiO2 via ultrasonic process with melastoma malabathricum as sustainable sensitizer for photovoltaic slar cell by Abdullah, Nur Munirah

“…Dye-sensitized solar cells (DSSCs) have been fabricated with doped Titanium Dioxide, TiO2 which are based on natural dyes from Malaysia tropical fruits, wherein contain interlocking groups; the carbonyl and hydroxyl groups of the anthocyanin molecule which enhance the photosensitization effect due to the high interaction on the surface of the film. …”
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Effect of reaction temperature on steam methane reforming’s yield over coated nickel aluminide (Ni3Al) catalyst in micro reactor by Madon, Rais Hanizam, Mas Fawzi, Mas Fawzi, Sarwani, Muhamad Khairul Ilman, Osman, S.A., Razali, Mohd Azahari, Mohammad, Abdul Wahab

“…The coating impregnation process, consist of a few stages which are substrates and solgel preparation, dip coating, calcination and reduction of oxide molecule. The coated Ni3Al were characterized by X-Ray Diffraction (XRD) and Temperature Programming Reduction (TPR) then activated using H2. …”
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