Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer by Conaway, E A, Short, S P, Williams, C S, Horwitz, B H, Wang, Chuanwu, Gong, Guanyu, Sheh, Alexander, Muthupalani, Sureshkumar, Bryant, Erin, Puglisi, Dylan A, Holcombe, Hilda R, Parry, Nicola, Bakthavatchalu, Vasudevan, Wogan, Gerald N, Tannenbaum, Steven R, Fox, James G

“…This process depends on nitric oxide (NO), a molecule with known mutagenic potential. We have previously hypothesized that production of NO by macrophages could be essential for Hh-driven carcinogenesis, however, whether Hh infection induces DNA damage in this model and whether this depends on NO has not been determined. …”
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Closing gaps in global access to biologic medicines : building tools to evaluate innovations in biomanufacturing by Guttieres, Donovan G

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Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity by Wiemer, Erik A.C., Ip, Pak Kan, Nagakura, Ikue, Petravicz, Jeremy C., Li, Keji, Sur, Mriganka

“…Keywords: autism spectrum disorder; glutamate receptors; ocular dominance plasticity; signaling; molecules; synapse development; visual cortex…”
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Reaction mechanisms for catalytic partial oxidation systems : application to ethylene epoxidation by Anantharaman, Bharthwaj

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Aqueous systems from first-principles : structure, dynamics and electron-transfer reactions by Sit, Patrick Hoi Land

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Preparation and applications of catalytic magnetic nanoparticles by Zhang, Huan, Ph. D. Massachusetts Institute of Technology

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Mechanistic investigation of an anticancer agent that damages DNA and interacts with the androgen receptor by Proffitt, Kyle David

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The role of the CD[subscript 5]8 locus in multiple sclerosis by De Jager, Philip L., Baecher-Allan, Clare, Maier, Lisa M., Arthur, Ariel T., Ottoboni, Linda, Barcellos, Lisa F., McCauley, Jacob L., Sawcer, Stephen, Goris, An, Saarela, Janna, Yelensky, Roman, Price, Alkes, Leppa, Virpi, Patterson, Nick, de Bakker, Paul I. W., Tran, Dong, Aubin, Cristin, Pobywajlo, Susan, Rossin, Elizabeth, Hu, Xinli, Ashley, Charles W., Choy, Edwin, Rioux, John D., Pericak-Vance, Margaret A., Ivinson, Adrian, Booth, David R., Stewart, Graeme J., Palotie, Aarno, Peltonen, Leena, Dubois, Benedicte, Haines, Jonathan L., Weiner, Howard L., Compston, Alastair, Hauser, Stephen L., Daly, Mark J., Reich, David, Oksenberg, Jorge R., Hafler, David A.

“…A whole genome association scan suggested that allelic variants in the CD58 gene region, encoding the costimulatory molecule LFA-3, are associated with risk of developing MS. …”
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Kinesin's force generation mechanism : study and practical application by Hesse, William R. (William Reichard)

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[alpha]v and [beta]1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways by Grodzinsky, Alan J., Chai, Diana H., Griggs, D. W., Arner, E. C.

“…Methods Bovine articular chondrocytes were seeded in 2% agarose gels (15 × 106 cells/mL) and incubated for 18 h with and without the presence of specific integrin blockers (small-molecule peptidomimetics, function-blocking antibodies, and RGD-containing disintegrins). …”
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Rational design to control multipotent stromal cell migration for applications in bone tissue engineering and injury repair by Wu, Shan, Ph. D. Massachusetts Institute of Technology

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Improvement of D-glucaric acid production in Escherichia coli by Shiue, Eric Chun-Jen

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Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery by Nguyen, David N., Mahon, Kerry P., Chikh, Ghania, Kim, Phillip, Chung, Hattie, Vicari, Alain P., Love, Kevin T., Goldberg, Michael Solomon, Chen, Steve, Krieg, Arthur M., Chen, Jianzhu, Langer, Robert, Anderson, Daniel Griffith

“…TLR7 and TLR 8 may be activated by their native ligands, single-stranded RNA, or by small molecules of the imidazoquinoline family. However the use of TLR7/8 agonists for in vivo therapy is limited by instability, in the case of RNA, or systemic biodistribution and toxicity in the case of small molecule agonists. …”
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Full dimensional Franck-Condon factors for the acetylene [~ over A] [superscript 1]A[subscript u] — [~ over X] [superscript 1Σ[+ over g] transition. II. Vibrational overlap factors... by Baraban, Joshua H., Field, Robert W., Park, Barratt

“…To our knowledge, this is the first full-dimensional Franck-Condon calculation on a tetra-atomic molecule undergoing a linear-to-bent geometry change. …”
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Insights into the Human Glycan Receptor Conformation of 1918 Pandemic Hemagglutinin–Glycan Complexes Derived from Nuclear Magnetic Resonance and Molecular Dynamics Studies by Elli, Stefano, Macchi, Eleonora, Rudd, Timothy R., Raman, Rahul, Sassaki, Guillherme, Viswanathan, Karthik, Yates, Edwin A., Naggi, Annamaria, Torri, Giangiacomo, Sasisekharan, Ram, Guerrini, Marco, Shriver, Zachary H.

“…In particular, it is interesting to observe how different HAs when binding to human or avian glycosidic receptors impose significantly different conformational states, in terms of the states sampled by the glycosidic backbone and/or the entire molecule shape (linear or bent), when compared to the corresponding unbound glycans. …”
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Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity by Peng, Chunte, Fedeles, Bogdan I., Singh, Vipender, Li, Deyu, Amariuta, Tiffany, Essigmann, John M., Tokmakoff, Andrei

“…Antiviral drugs designed to accelerate viral mutation rates can drive a viral population to extinction in a process called lethal mutagenesis. One such molecule is 5,6-dihydro-5-aza-2′-deoxycytidine (KP1212), a selective mutagen that induces A-to-G and G-to-A mutations in the genome of replicating HIV. …”
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Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells by Stanton, Brynne C., Siciliano, Velia, Wroblewska, Liliana, Clancy, Kevin, Trefzer, Axel C., Chesnut, Jonathan D., Weiss, Ron, Voigt, Christopher A., Ghodasara, Amar Navin

“…By taking advantage of the DAPG small molecule sensing mediated by the PhlF repressor, we introduce a new inducible system with 50-fold induction and a threshold of 0.9 μM DAPG, which is comparable to the classic Dox-induced TetR system. …”
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Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry by Hernychova, Lenka, Man, Petr, Verma, Chandra, Nicholson, Jude, Sharma, Carrie-Anne, Ruckova, Eva, Teo, Jin Yuan, Ball, Kathryn, Vojtesek, Borek, Hupp, Ted R.

“…MDM2 is a multidomain protein that functions as an E3 ubiquitin ligase, transcription repressor, mRNA-binding protein, translation factor, and molecular chaperone. The small molecule Nutlin-3 has been engineered to bind to the N-terminal hydrophobic pocket domain of MDM2. …”
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Glycosylated cationic block co-beta-peptide as antimicrobial and anti-biofilm agents against Gram-positive bacteria by Zhang, Kaixi

“…This new class of non-toxic molecule, effective against all bacterial sub-populations, has promising clinical potential. …”
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Tunable and stable swollen surfactant lamellar phases for hair-care applications by Goncalves Cardoso, Rui Andre

“…Next, the effects of fifteen commonly used compounds, such as “ureas”, hydrotrope molecules and short and intermediate-chain fatty acids and alcohols on the lamellar stability and packing structure upon thermal changes were examined. …”
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