BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner by Zhang, Tinghu, Kendall, Krystle R., Gray, Nathanael S., Haigis, Kevin M., Lau, Ken S., Lauffenburger, Douglas A

“…Methods: We searched for small molecule kinase inhibitors that preferentially affect the growth of colorectal cancer cells expressing mutant K-RAS. …”
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Solid-state NMR evidence for inequivalent GvpA subunits in gas vesicles by Sivertsen, Astrid C., Bayro, Marvin J., Belenky, Marina, Griffin, Robert Guy, Herzfeld, Judith

“…In particular, the asymmetric dimer can explain how the hydrogen bonds in the β-sheet portion of the molecule can be oriented optimally for strength while promoting stabilizing aromatic and electrostatic side-chain interactions among highly conserved residues and creating a large hydrophobic surface suitable for preventing water condensation inside the vesicle.…”
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Crystallographic and Biochemical Analysis of the Ran-Binding Zinc Finger Domain by Partridge, James R., Schwartz, Thomas

“…Each of the four zinc finger modules of Nup153 binds one Ran molecule in apparently non-allosteric fashion. The affinity is measurably higher for RanGDP than for RanGTP and varies modestly between the individual zinc fingers. …”
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Statistical characterization of multiple-reaction monitoring mass spectrometry (MRM-MS) assays for quantitative proteomics by Mani, D. R., Abbatiello, Susan E, Carr, Steven A

“…While the use of MRM-MS assays is well established in the small molecule realm, their introduction and use in proteomics is relatively recent. …”
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Sol-gel deposition of oxide-ion conducting thin films ; and, Liquid precursors to hafnium and tantalum carbides by Pell, Jennifer Woodbridge

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Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models by Saez-Rodriguez, Julio, Alexopoulos, Leonidas G., Zhang, MingSheng, Morris, Melody Kay, Lauffenburger, Douglas A., Sorger, Peter K.

“…Specifically, we created Boolean logic models of immediate-early signaling in liver cells by training a literature-based prior knowledge network against biochemical data obtained from primary human hepatocytes and 4 hepatocellular carcinoma cell lines exposed to combinations of cytokines and small-molecule kinase inhibitors. Distinct families of models were recovered for each cell type, and these families clustered topologically into normal and diseased sets.…”
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Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity by Larson, Alyssa Maxine, Wang, Hongmei, Cao, Yang, Jiang, Taijiao, Chen, Jianzhu, Klibanov, Alexander M.

“…Using the plaque reduction assay, relatively simple bicyclic quinone molecules, as well as multiple copies thereof covalently attached to a long polyglutamate-based polymeric chain, were examined as new inhibitors of various naturally occurring strains of influenza A virus. …”
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Sortase-mediated ubiquitylation of Histone H2B and its biological consequences by Díaz-Torres, José J. (José Javier)

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Reactive Oxygen Species Driven Angiogenesis by Inorganic Nanorods by Patra, Chitta Ranjan, Kim, Jong-Ho, Pramanik, Kallal, d’Uscio, Livius V., Patra, Sujata, Pal, Krishnendu, Ramchandran, Ramani, Strano, Michael S., Mukhopadhyay, Debabrata

“…Here we used single-walled carbon nanotube sensor array to measure the single-molecule efflux of H2O2 and a HPLC method for the determination of O2·– from endothelial cells in response to proangiogenic factors. …”
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function by Jolibois-Quinot, Remi

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Rapid, modular and reliable construction of complex mammalian gene circuits by Guye, Patrick, Li, Yinqing, Wroblewska, Liliana, Duportet, Xavier, Weiss, Ron

“…We show robust gene expression control of multiple transcription units by small molecule inducers in human cells with transient transfection and stable chromosomal integration of these circuits. …”
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On the Synergism Between H[subscript 2]O and a Tetrahydropyran Template in the Regioselective Cyclization of an Epoxy Alcohol by Byers, Jeffery A., Jamison, Timothy F.

“…Similar experiments for 1a suggest a competition between an unselective and a selective pathway requiring one and two water molecules in excess of those required to solvate 1a, respectively. …”
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Microbial Efflux Systems and Inhibitors: Approaches to Drug Discovery and the Challenge of Clinical Implementation by Kourtesi, Christina, Ball, Anthony R., Huang, Ying-Ying, Jachak, Sanjay M., Vera, D. Mariano A., Khondkar, Proma, Gibbons, Simon, Hamblin, Michael R., Tegos, George P.

“…The discovery of small molecule efflux system blockers has been an active and rapidly expanding research discipline. …”
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A role for PVRL4-driven cell-cell interactions in tumorigenesis by Pallasch, Christian, Braun, Christian Joerg, Hemann, Michael, Pavlova, Natalya N., Elia, Andrew E. H., Westbrook, Thomas F., Elledge, Stephen J.

“…A gain of function screen for genes that enable proliferation independently of matrix anchorage identified a cell adhesion molecule PVRL4 (poliovirus-receptor-like 4), also known as Nectin-4. …”
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Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling by Gupta, Piyush, Fillmore, Christine M., Rudnick, Jenny A., Caballero, Silvia, Keller, Patricia J., Kuperwasser, Charlotte, Lander, Eric Steven

“…Estrogen or FGF9 pretreatment induced CSC properties of breast cancer cell lines and freshly isolated breast cancer cells, whereas cotreatment of cells with tamoxifen or a small molecule inhibitor of FGFR signaling was sufficient to prevent the estrogen-induced expansion of CSCs. …”
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Harnessing glycomics technologies: Integrating structure with function for glycan characterization by Artpradit, Charlermchai, Raman, Rahul, Shriver, Zachary H., Ruchirawat, Mathuros, Sasisekharan, Ram, Robinson, Luke Nathaniel

“…Glycans, or complex carbohydrates, are a ubiquitous class of biological molecule which impinge on a variety of physiological processes ranging from signal transduction to tissue development and microbial pathogenesis. …”
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In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks by Menolascina, Filippo, Fiore, Gianfranco, Orabona, Emanuele, De Stefano, Luca, Ferry, Mike, Hasty, Jeff, di Bernardo, Mario, di Bernardo, Diego

“…We designed a simple control algorithm to automatically regulate the administration of inducer molecules to the cells by comparing the actual protein expression level in the cell population with the desired expression level. …”
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A pathway to diphosphorus from the dissociation of photoexcited tetraphosphorus by Wang, Lee-Ping, Tofan, Daniel, Chen, Jiahao, Van Voorhis, Troy, Cummins, Christopher C.

“…We report a computational study of an energetically favorable pathway for the excited-state dissociation of a tetrahedral P[subscript 4] molecule into two P[subscript 2] molecules via the simultaneous breaking of four chemical bonds along a highly symmetric (D[subscript 2d]) reaction pathway. …”
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One-Step Multipurpose Surface Functionalization by Adhesive Catecholamine by Kang, Sung Min, Hwang, Nathaniel S., Yeom, Jihyeon, Park, Sung Young, Messersmith, Phillip B., Choi, Insung S., Lee, Haeshin, Anderson, Daniel Griffith, Langer, Robert S

“…To achieve this goal, the incorporation of structurally diverse molecules onto any material surface is an essential capability for ideal surface modification. …”
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Spectrins in axonal cytoskeletons: Dynamics revealed by extensions and fluctuations by Lai, Lipeng, Cao, Jianshu

“…Instead of focusing on single molecules, we apply analytical results from the WLC model to both single molecule and network levels and focus on the relations between extensions and fluctuations. …”
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