Mechanisms for the Intracellular Manipulation of Organelles by Conventional Electroporation by Esser, Axel Thomas, Smith, Kyle C., Gowrishankar, Thiruvallur R., Vasilkoski, Zlatko, Weaver, James C.

“…Conventional electroporation (EP) changes both the conductance and molecular permeability of the plasma membrane (PM) of cells and is a standard method for delivering both biologically active and probe molecules of a wide range of sizes into cells. However, the underlying mechanisms at the molecular and cellular levels remain controversial. …”
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Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells by Das, Jayajit, Ho, Mary, Zikherman, Julie, Govern, Christopher C., Yang, Ming, Weiss, Arthur, Chakraborty, Arup K., Roose, Jeroen P.

“…Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, RasGRP and SOS, catalyze Ras activation in lymphocytes. …”
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BF[subscript 3]-Promoted Electrochemical Properties of Quinoxaline in Propylene Carbonate by Diesendruck, Charles E., Moore, Jeffrey S., Curtiss, Larry A., Assary, Rajeev S., Carino, Emily, Brushett, Fikile Richard

“…The use of Lewis acids to effectively “turn on” the electrochemical activity of organic molecules may lead to the development of new active material classes for energy storage applications.…”
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Genomic mining of prokaryotic repressors for orthogonal logic gates by Tamsir, Alvin, Clancy, Kevin, Peterson, Todd, Stanton, Brynne C., Nielsen, Alec Andrew, Voigt, Christopher A.

“…Genetic circuits perform computational operations based on interactions between freely diffusing molecules within a cell. When transcription factors are combined to build a circuit, unintended interactions can disrupt its function. …”
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Theranostic applications of nanoparticles in neurodegenerative disorders by Ramanathan, Sahana, Archunan, Govindaraju, Sivakumar, Muthusamy, Selvan, Subramanian Tamil, Fred, A. Lenin, Kumar, Sundramurthy, Gulyás, Balázs, Padmanabhan, Parasuraman

“…Moreover, the blood–brain barrier (BBB) effectively blocks the transfer of cells, particles and large molecules, ie, drugs, across the brain. The most important challenge in the treatment of neurodegenerative diseases is the development of targeted drug delivery system. …”
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Floquet mechanism for non-Abelian fractional quantum hall states by Lee, Ching Hua, Ho, Wen Wei, Yang, Bo, Gong, Jiangbin, Papić, Zlatko

“…Finally, we propose an implementation of the protocol in optically dressed ultracold polar molecules with modulated Rabi frequencies.…”
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Formation of hierarchical In2S3–CdIn2S4 heterostructured nanotubes for efficient and stable visible light CO2 reduction by Wang, Sibo, Guan, Bu Yuan, Lu, Yan, Lou, David Xiong Wen

“…Accordingly, the hierarchical heterostructured nanotubes facilitate separation and migration of photoinduced charge carriers, enhance the adsorption and concentration of CO2 molecules, and offer rich active sites for surface redox reactions. …”
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Pyrene-functionalized polymeric carbon nitride with promoted aqueous–organic biphasic photocatalytic CO2 reduction by Gong, Xuezhong, Yu, Sijia, Guan, Meili, Zhu, Xianglin, Xue, Can

“…The great biphasic activities are attributed to the increased lipophilicity from surface pyrene-functional groups, which allows the hydrophobic alkene molecules to readily approach the PCN surface and react with the hydroxyl radicals created from –OH oxidation by photogenerated holes. …”
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Rationally designed hierarchical N-doped carbon@NiCo2O4 double-shelled nanoboxes for enhanced visible light CO2 reduction by Wang, Sibo, Guan, Bu Yuan, Lou, David Xiong Wen

“…This smart design rationally combines the structural and functional advantages of catalytically active Co and Ni species with conductive nitrogen-doped carbon into a three-dimensional hollow nanoarchitecture, which can remarkably facilitate the migration and separation of photogenerated charge carriers, enhance the adsorption and concentration of CO2 molecules, and provide more active sites for photochemical reactions. …”
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Single cobalt atoms anchored on porous N-doped graphene with dual reaction sites for efficient Fenton-like catalysis by Li, Xuning, Huang, Xiang, Xi, Shibo, Miao, Shu, Ding, Jie, Cai, Weizheng, Liu, Song, Yang, Xiaoli, Yang, Hongbin, Gao, Jiajian, Wang, Junhu, Huang, Yanqiang, Zhang, Tao, Liu, Bin

“…Our experiments and density functional theory (DFT) calculations show that the CoN4 site with a single Co atom serves as the active site with optimal binding energy for PMS activation, while the adjacent pyrrolic N site adsorbs organic molecules. The dual reaction sites greatly reduce the migration distance of the active singlet oxygen produced from PMS activation and thus improve the Fenton-like catalytic performance.…”
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Nanomechanically visualizing drug-cell interaction at the early stage of chemotherapy by Wu, Yun-Long, Engl, Wilfried, Hu, Benhui, Cai, Pingqiang, Leow, Wan Ru, Tan, Nguan Soon, Lim, Chwee Teck, Chen, Xiaodong

“…Herein, we report that the nanomechanical traction force is sensitive enough to reflect the early cellular response upon the addition of chemotherapeutical molecules in a real-time and noninvasive manner, due to interactions between chemotherapeutic drug and its cytoskeleton targets. …”
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Poly(ferrocenylsilane) electrolytes as a gold nanoparticle foundry : "two-in-one" redox synthesis and electrosteric stabilization, and sensing applications by Song, J., Tan, Y. N., Jańczewski, D., Hempenius, M. A., Xu, J. W., Tan, H. R., Vancso, Gyula Julius

“…Feasibility studies reported here indicate that the particles described can be applied as a colorimetric probe for the detection of redox molecules, e.g. vitamin C, in a controlled and facile manner.…”
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One-step synthesis of cyclodextrin-capped gold nanoparticles for ultra-sensitive and highly-integrated plasmonic biosensors by Zhang, Nancy Meng Ying, Qi, Miao, Wang, Zhixun, Wang, Zhe, Chen, Mengxiao, Li, Kaiwei, Shum, Ping, Wei, Lei

“…Integrated with a microfiber, the β-CD-capped AuNPs deliver promising localized surface plasmon resonance properties and ultralow detection limit of cholesterol molecules of 5 aM. The selective recognition of our proposed biosensor to cholesterol is further verified by interference study and analysis of real human serum samples. …”
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Dual-targeting dual-action platinum(IV) platform for enhanced anticancer activity and reduced nephrotoxicity by Babak, Maria V., Zhi, Yang, Czarny, Bertrand, Toh, Tan Boon, Hooi, Lissa, Chow, Edward Kai-Hua, Ang, Wee Han, Gibson, Dan, Pastorin, Giorgia

“…Upon intracellular reduction, these PtIV prodrugs released two bioactive molecules, acting both on the mitochondrial and on the nuclear DNA. …”
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Synthesizing high-volume chemicals from CO2 without direct H2 input by Tao, Longgang, Choksi, Tej S., Liu, Wen, Pérez-Ramírez, Javier

“…This CO2 utilization approach can be potentially applied to synthesize 8 emission-intensive molecules, including olefins and epoxides. We discuss catalytic systems and reactor concepts that can overcome practical challenges, e.g. thermodynamic limitations, over-oxidation, coking and heat management. …”
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Temporal pressure enhanced topical drug delivery through micropore formation by Lio, Daniel Chin Shiuan, Chia, Ruining, Kwek, Milton Sheng Yi, Wiraja, Christian, Madden, Leigh Edward, Chang, Hao, S. Mohideen Abdul Khadir, Wang, Xiaomeng, Becker, David Lawrence, Xu, Chenjie

“…Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). …”
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Self-assembling β-glucan nanomedicine for the delivery of siRNA by Lee, Kyungwoo, Min, Daejin, Choi, Yonghyun, Yoon, Semi, Jang, Jaehee, Hwang, Jangsun, Jeon, Hojeong, Cho, Yong Woo, Choi, Jonghoon

“…In this study, β-glucan nanoparticles were designed and manufactured to deliver genetic material to the target cells. The β-glucan molecules were self-assembled with an siRNA into nanoparticles of 300–400 nm in diameter via a conformational transition process, in order to construct a gene delivery system. …”
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Regulating the reactivity of black phosphorus via protective chemistry by Liu, Xiao, Xiao, Liangping, Weng, Jian, Xu, Qingchi, Li, Wanli, Zhao, Chunhui, Xu, Jun, Zhao, Yanli

“…Rationally regulating the reactivity of molecules or functional groups is common in organic chemistry, both in laboratory and industry synthesis. …”
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Human cells can adaptively evolve to hypomorphic mutations in an essential gene of the nuclear pore complex by Targa, Altea

“…By dissecting both early and long- term mechanisms of adaptation in independent clones, I observed that early adaptation might correlate with transcriptional changes and upregulation of molecules known to interact with the NPC. In contrast, long-term adaptation occurred via focal amplification of NUP58 and restoration of mutant protein expression. …”
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Carbene-catalyzed alkylation of carboxylic esters via direct photoexcitation of acyl azolium intermediates by Ren, Shi-Cao, Lv, Wen-Xin, Yang, Xing, Yan, Jia-Lei, Xu, Jun, Wang, Fang-Xin, Hao, Lin, Chai, Huifang, Jin, Zhichao, Chi, Robin Yonggui

“…Sophisticated structures, including those present in medicines, can be incorporated into ketone molecules using our approach via very mild conditions that tolerate various functional groups.…”
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