Lagage et al, 2022: Adaptation delay causes a burst of mutations in bacteria responding to oxidative stress by Lagage, V, Uphoff, S, Chen, V

“…We have also included an Excel file named “fractionofboundmoleculesoxyrhalo-pol1halo-dfurpol1halo”, containing the value of the fraction of bound molecules for the relevant strains in untreated and hydrogen peroxide-treated conditions. …”

Investigation of the effects of IGF-1 receptor blockade on chemoresistance of advanced melanoma by Ramcharan, R, Roger Ramcharan

“…The aims of this study were to test whether melanoma cells could be sensitized to TMZ by small molecule IGF1R inhibitors, and to explore the mechanism of any chemosensitization. …”

Epigenetic modification of the frataxin gene for the treatment of Friedreich’s ataxia by Vilema Enriquez, MG

“…</p> <p>In summary, the work has defined SUV4-20 as a novel therapeutic target for FRDA and identified compound A-196 as a potential small molecule candidate for hit-to-lead development as a new drug for this fatal disease. …”

Structural and kinetic studies on beta-lactamase mechanism and inhibition by Cahill, S

“…The activity of these molecules against clinically derived resistant bacterial strains is also explored.…”

Cytokine and growth factor regulation of murine macrophage scavenger receptor expression and function by De Villiers, W, Willem Johan Simon de Villiers

“…This thesis examines the effects of some of these soluble factors on a murine macrophage membrane molecule, the macrophage scavenger receptor (MSR), considered pivotal in foam cell formation and atherogenesis. …”

Amino sugars and their glycosides by Hindle, N, Fleet, G, Hindle, Neil A.

“…This would have a second nitrogen functionality in the molecule allowing the possibility of the inclusion of the tetrazole into a peptide sequence. …”

Computationally interrogating enzyme electrochemistry for rational mutation of metalloproteins by Lloyd-Laney, H

“…<p>This thesis was inspired by an interest in the metalloenzymes: profoundly complex catalysts that perform the redox-mediated small molecule conversions that underpin the biosphere. The principal methodology is computational analysis of protein-film voltammetry (PFV), an experimental technique wherein an electro-active protein (such as a metalloenzyme) is chemically linked to an electrode, and subjected to a time-varying potential input, with a corresponding current response from two processes; double-layer capacitance and electron-hopping Faradaic reactions (catalytic processes also generate current, but are beyond the scope of the thesis). …”

Investigating the role of the anti-malarial drug Atovaquone in anti-cancer therapy by Watson, D, Coates, J

“…</p> <p>Using a high-throughput small molecule screen, our team previously identified that the FDA-approved, anti-malarial drug Atovaquone (ATQ) reduces oxygen consumption, upregulates glycolysis, and alleviates tumour hypoxia in vivo. …”

Synthesis of polymeric materials derived from abundant natural feedstocks using non-toxic heavy metals by Navickaite, G

“…</p> <br> <p>The reactivity of the bismuth amide was also explored towards small molecules. Facile addition of C-O, C-S, and C-N bonds across the Bi-N bond was observed for electrophilic, unhindered heteroallenes. …”

Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease by Danoy, P, Pryce, K, Hadler, J, Bradbury, L, Farrar, C, Pointon, J, Ward, M, Weisman, M, Reveille, J, Wordsworth, B, Stone, M, Maksymowych, W, Rahman, P, Gladman, D, Inman, R, Brown, M

“…STAT3 is a key signaling molecule within the Th17 lymphocyte differentiation pathway and further enhances the case for a major role of this T-lymphocyte subset in ankylosing spondylitis. …”

Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…Examination of a focused small-molecule library revealed differences in potency amongst TET isoforms and 2OG-dependent oxygenases. …”

From macrocycles to quantum rings: Does aromaticity have a size limit? by Jirásek, M, Anderson, HL, Peeks, MD

“…The ring currents of aromatic and antiaromatic molecules are remarkable emergent phenomena. A ring current is a quantum-mechanical feature of the whole system, and its existence cannot be inferred from the properties of the individual components of the ring. …”

The composition of Titan's stratosphere from Cassini/CIRS mid-infrared spectra by Coustenis, A, Achterberg, R, Conrath, B, Jennings, D, Marten, A, Gautier, D, Nixon, C, Flasar, F, Teanby, N, Bezard, B, Samuelson, R, Carlson, R, Lellouch, E, Bjoraker, G, Romani, P, Taylor, F, Irwin, P, Fouchet, T, Hubert, A, Orton, G, Kunde, V, Vinatier, S, Mondellini, J, Abbas, M, Courtin, R

“…For the more important increases in the northern latitudes, the transition occurs roughly between 30 and 50 degrees north latitude, depending on the molecule. Note however that the very high-northern latitude results from tours TB-T10 bear large uncertainties due to few available data and problems with latitude smearing effects. …”

Adsorption and micellisation of partially- and fully-fluorinated surfactants by Downer, A, Eastoe, J, Pitt, A, Penfold, J, Heenan, R

“…At the critical micelle concentration (cmc) the fully fluorinated surfactant adsorbs most strongly, in that NR gave areas per molecule for the Na PFN and H Na PFN of 41 and 44 A2, respectively, whereas drop volume tensiometry gave 43 and 51 A2. …”

Cryocrystallographic and mechanistic studies on glycogen phosphorylase by Mitchell, E

“…Refinement has produced a new higher precision native model (<em>R</em> factor currently 22.8%) containing additional N terminal residues (14-18) and 330 new water molecules. A molecule of glycerol, the cryoprotectant, was located at the active site. …”

Structural studies of icosahedral viruses by Zhang, H

“…An atomic level mechanism of pH dependant conformation changes was revealed, including a re-arrangement of 3 bent helices into one long straight helix protruding out of the molecule, and a transformation from a β-sheet to an α-helix. …”

Ischaemia / reperfusion injury in renal transplantation by Koo, D, Dicken D. H. Koo

“…Lec-SOD bound with high affinity to macro- and microvascular endothelial cells under cold hypoxic conditions following incorporation into Marshall's preservation solution, significantly inhibiting cold hypoxia induced cell death, adhesion molecule induction and neutrophil adhesion. Furthermore, preservation of kidneys with lec- SOD for 18 hr in an experimental model of chronic renal allograft rejection, significantly attenuated neutrophil infiltration and MHC Class I induction day 1 post-transplant, with improved long term renal function.…”

Peripherin is a biomarker of axonal damage in peripheral nervous system disease by Keddie, S, Smyth, D, Keh, RYS, Chou, MKL, Grant, D, Surana, S, Heslegrave, A, Zetterberg, H, Wieske, L, Michael, M, Eftimov, F, Bellanti, R, Rinaldi, S, Hart, MS, Petzold, A, Lunn, MP

“…We developed an immunoassay using single molecule array technology for the detection of serum peripherin as a biomarker for PNS axonal damage. …”

mu SR investigation of magnetism in kappa-(ET)(2)X: antiferromagnetism by Huddart, BM, Lancaster, T, Blundell, SJ, Guguchia, Z, Taniguchi, H, Clark, SJ, Pratt, FL

“…ET stands for the electron donor molecule bis(ethylendithio)tetrathiafulvalene and X is an anion. …”

Structural chemistry of transition metal dicyanometallates by Hill, J

“…These new compounds are placed within the context of all known dicyanometallate frameworks of general formula A_mB(L)X_n·G where A is an extra- framework cation; B is a metal cation; X is [Au(CN)₂]⁻, [Ag(CN)₂]⁻, or [Cu(CN)₂]⁻; L is a neutral ligand bound to the node metal centre (i.e., not to the linker metal); and G is a non-coordinating guest molecule. They are organised according to their stoichiometry, A_mBX_n, showing the dual importance of size/shape of extra- framework cations and the coordinational preferences of the framework cation. …”