S-Alkylated/aralkylated 2-(1H-indol-3-yl-methyl)-1,3,4- oxadiazole-5-thiol derivatives. 1. Synthesis and Characterization 由 Rubab, Kaniz, Abbasi, Muhammad A., Rehman, Aziz-ur, Siddiqui, Sabahat Zahra, Akhtar, Muhammad Nadeem

“...Structural elucidation was done by IR, 1H-NMR and EI-MS techniques Results: 2-(1H-indol-3-ylmethyl)-1,3,4-oxadiazole-5-thiol (4) was synthesized as the parent molecule and was characterized by IR and the spectrum showed peaks resonating at (cm-1) 2925 (Ar-H), 2250 (S-H ), 1593 (C=N ) and 1527 (Ar C=C ); 1H-NMR spectrum showed signals at δ 11.00 (s, 1H, NH-1ʹ), 7.49 ( br.d, J = 7.6 Hz, 1H, H-4'), 7.37 (br.d, J = 8.0 Hz, 1H, H-7'), 7.34 (br.s, 1H, H-2'), 7.09 (t, J = 7.6Hz, 1H, H-5'), 7.00 (t, J = 7.6 Hz, 1H, H-6') and 4.20 (s, 2H, CH2-10ʹ). ...”
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Influence of metallic and basic sites of Ni-promoted SBA-15 on the mechanistic path of CO2-methanation 由 Setiabudi, Herma Dina, Triwahyono, Sugeng, Vo, Dai Viet N., Nurul Aini, Mohamed Razali

“...Firstly, the CO2 and H2 molecule were dissociated to CO, O, and H atoms on the surface of Ni metal active sites and spillover onto the support to form unidentate carbonates, bidentate carbonates and linear carbonyl as the main adsorption species. ...”
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Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer 由 Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.

“...The present work shows that 5ClC is intrinsically mutagenic, both in vitro and, at a level of a single molecule per cell, in vivo. Using biochemical and genetic approaches, we have quantified the mutagenic and toxic properties of 5ClC, showing that this lesion caused C→T transitions at frequencies ranging from 3–9% depending on the polymerase traversing the lesion. ...”
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On the origin of photons : understanding excitons and multiexcitons in colloidal semiconductor nanocrystals 由 Bischof, Thomas Stanley

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Deregulation of S-adenosylmethionine biosynthesis and regeneration improves methylation in the E. coli de novo vanillin biosynthesis pathway 由 Hyun, Jason C., Kunjapur, Aditya Mohan, Prather, Kristala L. Jones

“...Background Vanillin is an industrially valuable molecule that can be produced from simple carbon sources in engineered microorganisms such as Saccharomyces cerevisiae and Escherichia coli. ...”
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Relaxation-compensated difference spin diffusion NMR for detecting 13C–13C long-range correlations in proteins and polysaccharides 由 Wang, Tuo, Williams, Jonathan Kyle, Schmidt-Rohr, Klaus, Hong, Mei

“...In 2D and 3D correlation spectra of uniformly 13C-labeled biomolecules, inter-residue, inter-segmental, and intermolecular 13C–13C cross peaks that provide important long-range distance constraints for three-dimensional structures often overlap with short-range cross peaks that only reflect the covalent structure of the molecule. It is therefore desirable to develop new approaches to obtain spectra containing only long-range cross peaks. ...”
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Isopropanol production with engineered Cupriavidus necator as bioproduction platform 由 Grousseau, Estelle, Lu, Jingnan, Gorret, Nathalie, Guillouet, Stéphane E., Sinskey, Anthony J

“...Alleviating our society’s dependence on petroleum-based chemicals has been highly emphasized due to fossil fuel shortages and increasing greenhouse gas emissions. Isopropanol is a molecule of high potential to replace some petroleum-based chemicals, which can be produced through biological platforms from renewable waste carbon streams such as carbohydrates, fatty acids, or CO2. ...”
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Characterization and modification of enzymes in the 2-ketoisovalerate biosynthesis pathway of Ralstonia eutropha H16 由 Lu, Jingnan, Brigham, Christopher J., Plassmeier, Jens K., Sinskey, Anthony J

“...2-Ketoisovalerate is an important cellular intermediate for the synthesis of branched-chain amino acids as well as other important molecules, such as pantothenate, coenzyme A, and glucosinolate. ...”
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Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12 由 Cunden, Lisa Stephanie, Gaillard de Saint Germain, Alethe, Nolan, Elizabeth Marie

“...To evaluate the Zn(II)-binding sites of S100A12 in solution, we present studies using Co(II) as a spectroscopic probe and chromophoric small-molecule chelators in Zn(II) competition titrations. ...”
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Interactions governing the self-assembly of globular protein-polymer block copolymers 由 Lam, Christopher N. (Christopher Nguyen)

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Quantitative Tissue Spectroscopy of Near Infrared Fluorescent Nanosensor Implants 由 Iverson, Nicole M., Bisker Raviv, Gili Hana, Farias, Edgardo, Ivanov, Vsevolod M, Ahn, Jiyoung, Wogan, Gerald N, Strano, Michael S.

“...Implantable, near infrared (nIR) fluorescent nanosensors are advantageous for in vivo monitoring of biological analytes since they can be rendered selective for particular target molecule while utilizing their unique optical properties and the nIR tissue transparency window for information transfer without an internal power source or telemetry. ...”
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The Evolution of Pd 由 Sather, Aaron C., Buchwald, Stephen Leffler

“...In this Account, we describe the discovery and development of a Pd-catalyzed C-F cross-coupling process and the systematic developments that made this once hypothetical reaction possible.Key to these developments was the discovery of an unusual in situ ligand modification process in which a molecule of substrate is incorporated into the ligand scaffold and the identity of the modifying group is crucial to the outcome of the reaction. ...”
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Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer 由 Conaway, E A, Short, S P, Williams, C S, Horwitz, B H, Wang, Chuanwu, Gong, Guanyu, Sheh, Alexander, Muthupalani, Sureshkumar, Bryant, Erin, Puglisi, Dylan A, Holcombe, Hilda R, Parry, Nicola, Bakthavatchalu, Vasudevan, Wogan, Gerald N, Tannenbaum, Steven R, Fox, James G

“...This process depends on nitric oxide (NO), a molecule with known mutagenic potential. We have previously hypothesized that production of NO by macrophages could be essential for Hh-driven carcinogenesis, however, whether Hh infection induces DNA damage in this model and whether this depends on NO has not been determined. ...”
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Closing gaps in global access to biologic medicines : building tools to evaluate innovations in biomanufacturing 由 Guttieres, Donovan G

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Major Vault Protein, a Candidate Gene in 16p11.2 Microdeletion Syndrome, Is Required for the Homeostatic Regulation of Visual Cortical Plasticity 由 Wiemer, Erik A.C., Ip, Pak Kan, Nagakura, Ikue, Petravicz, Jeremy C., Li, Keji, Sur, Mriganka

“...Keywords: autism spectrum disorder; glutamate receptors; ocular dominance plasticity; signaling; molecules; synapse development; visual cortex...”
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The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC 由 Kraemer, James A., Sanderlin, Allen G, Laub, Michael T

“...In bacteria, starvation triggers production of a signaling molecule called ppGpp (guanosine tetraphosphate) that helps reprogram cellular physiology, including inhibiting new rounds of DNA replication. ...”
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Reaction Mechanism Generator: Automatic construction of chemical kinetic mechanisms 由 Gao, Connie W, Allen, Joshua W, Green, William H, West, Richard H

“...Running time: From 30 s for the simplest molecules, to up to several weeks, depending on the size of the molecule and the conditions of the reaction system chosen....”
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Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome 由 McCamphill, Patrick K., Stoppel, Laura J., Senter, Rebecca K., Lewis, Michael C., Heynen, Arnold J., Stoppel, David C., Sridhar, Vinay, Collins, Katie A., Shi, Xi, Pan, Jen Q., Madison, Jon, Cottrell, Jeffrey R., Huber, Kimberly M., Scolnick, Edward M., Holson, Edward B., Wagner, Florence F., Bear, Mark F.

“...Targets of lithium include paralogs of glycogen synthase kinase 3 (GSK3), and nonselective small-molecule inhibitors of these enzymes improved disease phenotypes in a fragile X syndrome mouse model. ...”
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Organometallic Palladium Reagents for Polypeptide Bioconjugation and Macrocyclization 由 Mallek, Aaron J.

“...These procedures enable the chemoselective conjugation of functionally diverse small molecule pharmaceuticals to p-aminophenylalanine containing derivatives of cell-penetrating peptides....”
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MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection 由 Khuzwayo, Sharon, Mthembu, Maphe, Meermeier, Erin W, Prakadan, Sanjay M, Kazer, Samuel W, Bassett, Thierry, Nyamande, Kennedy, Khan, Dilshaad Fakey, Maharaj, Priya, Mitha, Mohammed, Suleman, Moosa, Mhlane, Zoey, Ramjit, Dirhona, Karim, Farina, Shalek, Alex K, Lewinsohn, David M, Ndung’u, Thumbi, Wong, Emily B

“...<jats:p>Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosal surfaces are often phenotypically and functionally distinct from those in the peripheral circulation, knowledge about the characteristics of MAIT cells at the lung mucosal surface, the site of exposure to respiratory pathogens, is limited. ...”
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