Dynamic Remodeling of Microbial Biofilms by Functionally Distinct Exopolysaccharides by Chew, Su Chuen, Kundukad, Binu, Seviour, Thomas, van der Maarel, Johan R. C., Yang, Liang, Rice, Scott A., Doyle, Patrick S., Sjelleberg, Staffan

“…The structure and rheological properties of the matrix at the microscale influence the retention and transport of molecules and cells in the biofilm, thereby dictating population and community behavior. …”
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Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells by Torres, Alexis J., Contento, Rita Lucia, Gordo, Susana, Wucherpfennig, Kai W., Love, John C

“…Immobilized bilayers presenting tethered ligands on planar substrates have yielded both spatio-temporal and structural insights into how T cell receptors (TCRs) reorganize during the initial formation of synapses upon recognition of peptide antigens bound to major histocompatibility complex (MHC) molecules. The prototypical configuration of these assays, however, limits the extent to which the kinetics and structure of the supramolecular activation clusters of the synapse (that occur in seconds or minutes) can be related to subsequent complex cellular responses, such as cytokine secretion and proliferation, occurring over hours to days. …”
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Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro by Chu, Li-Fang, Surani, M. Azim, Jaenisch, Rudolf, Zwaka, Thomas P.

“…Finally, using genetic ablation or distinct small molecules [7 and 8], we show that epiblast cells can become ESCs without first acquiring Blimp1 positivity. …”
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Low-Temperature Synthesis of Anatase TiO[subscript 2] Nanoparticles with Tunable Surface Charges for Enhancing Photocatalytic Activity by Li, Ye, Qin, Zhenping, Guo, Hongxia, Yang, Hanxiao, Zhang, Guojun, Ji, Shulan, Zeng, Tingying

“…In comparison with TiO[subscript 2], PSS-TiO[subscript 2] exhibited dramatic adsorption and degradation of dye molecules, while the PEI modified TiO[subscript 2] nanoparticles showed lower photocatalytic activity. …”
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Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy number by Pang, Yan Ling Joy, Abo, Ryan, Levine, Stuart S., Dedon, Peter C

“…To this end, we developed a next-generation sequencing method that exploits the paucity of ribonucleoside modifications at the 3′-end of tRNAs to quantify changes in all cellular tRNA molecules. Application of this tRNA-seq method to Saccharomyces cerevisiae identified all 76 expressed unique tRNA species out of 295 coded in the yeast genome, including all isoacceptor variants, with highly precise relative (fold-change) quantification of tRNAs. …”
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First-principles investigation of organic photovoltaic materials C[subscript 60], C[subscript 70], [C[subscript 60]]PCBM, and bis-[C[subscript 60]]PCBM using a many-body G[subscrip... by Qian, Xiaofeng, Umari, Paolo, Marzari, Nicola

“…The density of states of all three molecules is also compared to photoemission and inverse photoemission spectra measured on thin films, and they exhibit a close agreement—a rigid energy-gap renormalization owing to intermolecular interactions in the thin films. …”
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Lipid-like Self-Assembling Peptide Nanovesicles for Drug Delivery by Fatouros, Dimitrios G., Lamprou, Dimitrios A., Urquhart, Andrew J., Yannopoulos, Spyros N., Vizirianakis, Ioannis S., Zhang, Shuguang, Koutsopoulos, Sotirios

“…Encapsulation of probe molecules and release studies through the peptide bilayer suggest that peptide nanovesicles may be good candidates for sustained release of pharmaceutically active hydrophilic and hydrophobic compounds. …”
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Molecular packing and electronic processes in amorphous-like polymer bulk heterojunction solar cells with fullerene intercalation by Hu, Xiao, Xiao, Ting, Xu, Haihua, Grancini, Giulia, Mai, Jiangquan, Petrozza, Annamaria, Jeng, U-Ser, Wang, Yan, Xin, Xin, Lu, Yong, Choon, Ng Siu, Ong, Beng S., Lu, Xinhui, Zhao, Ni

“…Grazing incidence X-ray scattering measurements reveal the lower-ordered nature of the BHJ system as well as an intermixing morphology with intercalation of fullerene molecules between the PFBT-T20TT lamella. Steady-state and transient photo-induced absorption spectroscopy reveal ultrafast charge transfer (CT) at the PFBT-T20TT/fullerene interface, indicating that the CT process is no longer limited by exciton diffusion. …”
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Graphene-MoS2 hybrid nanostructures enhanced surface plasmon resonance biosensors by Zeng, Shuwen, Hu, Siyi, Xia, Jing, Anderson, Tommy, Dinh, Xuan-Quyen, Meng, Xiang-Min, Coquet, Philippe, Yong, Ken-Tye

“…In this work, we propose a new configuration of surface plasmon resonance (SPR) sensor that is based on graphene–MoS2 hybrid structures for ultrasensitive detection of molecules. The proposed system displays a phase-sensitivity enhancement factor of more than 500-fold when compared to the SPR sensing scheme without the graphene–MoS2 coating or with only graphene coating. …”
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High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5 by Liu, Chuan-Fa, Zheng, Jie, Yong, Hui Yee, Panutdaporn, Nantika, Tang, Kai, Luo, Dahai

“…We also present a high-resolution protein surface mapping technique that refines the cooperative oligomerization model of neighboring MDA5 molecules on long duplex RNA. Taken together, our data provide a high-resolution view of RLR activation in solution and offer new evidence for the molecular mechanism of RLR activation.…”
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Using the Langmuir–Schaefer technique to fabricate large-area dense SERS-active Au nanoprism monolayer films by Lee, Yih Hong, Lee, Choon Keong, Tan, Baorui, Tan, Joel Ming Rui, Phang, In Yee, Ling, Xing Yi

“…SERS enhancement factors reaching 104 for non-resonant probe molecules are achieved.…”
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Coupled mutations-enabled glycerol transportation in an aquaporin Z mutant by Ping, Zhi, Zhou, Feng, Lin, Xin, Su, Haibin

“…Escherichia coli Aqp Z transports water molecules only, whereas Glp F is permeable to glycerol. …”
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Immunomic identification of malaria antigens associated with protection in mice by Siau, Anthony, Huang, Ximei, Loh, Han Ping, Zhang, Neng, Meng, Wei, Sze, Siu Kwan, Renia, Laurent, Preiser, Peter

“…The nature of parasite molecules associated with protection remains elusive. …”
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Diverse bonding activations in the reactivity of a pentaphenylborole toward sodium phosphaethynolate : heterocycle synthesis and mechanistic studies by Li, Yan, Siwatch, Rahul Kumar, Mondal, Totan, Li, Yongxin, Ganguly, Rakesh, Koley, Debasis, So, Cheuk-Wai

“…Density functional theory calculations indicate that the [OCP]- anion prefers the form of phosphaethynolate -O-C≡P over phosphaketenide O═C═P- to interact with two molecules of 1, along with various B-C, C-P, and C-C bond activations to form 2. …”
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Light, the universe and everything-12 Herculean tasks for quantum cowboys and black diamond skiers by Agarwal, Girish, Allen, Roland E., Bezdekova, Iva, Boyd, Robert W., Chen, Goong, Hanson, Ronald, Hawthorne, Dean L., Hemmer, Philip, Kim, Moochan B., Kocharovskaya, Olga, Lee, David M., Lidstrom, Sebastian K., Lidstrom, Suzy, Losert, Harald, Maier, Helmut, Neuberger, John W., Padgett, Miles J., Raizen, Mark, Rajendran, Surjeet, Rasel, Ernst, Schleich, Wolfgang P., Scully, Marlan O., Shchedrin, Gavriil, Shvets, Gennady, Sokolov, Alexei V., Svidzinsky, Anatoly, Walsworth, Ronald L., Weiss, Rainer, Wilczek, Frank, Willner, Alan E., Yablonovich, Eli, Zheludev, Nikolay

“…(10) What new understanding of materials and biological molecules will result from their dynamical characterization with free electron lasers? …”
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Cysteine-rich peptide fingerprinting as a general method for herbal analysis to differentiate Radix Astragali and Radix Hedysarum by Huang, Jiayi, Wong, Ka Ho, Tay, Stephanie Victoria, How, Adrian, Tam, James P.

“…Current authentication methods, focusing on the chemical composition differences of herbal medicines based on small molecules, have limitations when these chemical markers are found in many species. …”
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Rhenium diselenide (ReSe2) near-infrared photodetector : performance enhancement by selective p-doping technique by Kim, Jinok, Heo, Keun, Kang, Dong-Ho, Shin, Changhwan, Lee, Sungjoo, Yu, Hyun-Yong, Park, Jin-Hong

“…Because the p-doping of ReSe2 originates from the charge transfer from un-ionized Cl molecules in the HCl to the ReSe2 surface, by adjusting the concentration of the HCl solution from 0.1 to 10 m, the doping concentration of the ReSe2 is controlled between 3.64 × 1010 and 3.61 × 1011 cm-2. …”
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Direct metal writing and precise positioning of gold nanoparticles within microfluidic channels for SERS sensing of gaseous analytes by Lee, Mian Rong, Lee, Hiang Kwee, Yang, Yijie, Koh, Charlynn Sher Lin, Lay, Chee Leng, Lee, Yih Hong, Phang, In Yee, Ling, Xing Yi

“…We find that the microstructures exhibit an SERS enhancement factor of >105 and demonstrate remote writing of well-defined Au microstructures within a microfluidic channel for the SERS detection of gaseous molecules. We showcase in situ SERS monitoring of gaseous 4-methylbenzenethiol and real-time detection of multiple small gaseous species with no specific affinity to Au. …”
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Microenvironmental hypoxia induces dynamic changes in lung cancer synthesis and secretion of extracellular vesicles by Tse, Shun Wilford, Tan, Chee Fan, Park, Jung Eun, Gnanasekaran, JebaMercy, Gupta, Nikhil, Low, Jee Keem, Yeoh, Kheng Wei, Chng, Wee Joo, Tay, Chor Yong, McCarthy, Neil E., Lim, Sai Kiang, Sze, Siu Kwan

“…Moreover, lung cancer-derived EVs were also enriched in signalling molecules capable of inducing epithelial-mesenchymal transition in recipient cancer cells to promote their migration and invasion. …”
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3D covalent organic framework for morphologically induced high-performance membranes with strong resistance toward physical aging by Yang, Yanqin, Goh, Kunli, Weerachanchai, Piyarat, Bae, Tae-Hyun

“…Herein, a three-dimensional covalent organic framework (3D-COF) with a secondary amine-containing backbone was designed to offer large surface area, high porosity and good affinity toward CO2 molecules. Membranes prepared from this 3D-COF filler and a 6FDA-DAM polyimide matrix demonstrated a more significant enhancement in the CO2/CH4 separation performance, which was unattainable by its 2D-COF analogue. …”
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