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    Conserved features of intermediates in amyloid assembly determine their benign or toxic states by Krishnan, Rajaraman, Goodman, Jessica L., Mukhopadhyay, Samrat, Pacheco, Chris D., Lemke, Edward A., Deniz, Ashok A., Lindquist, Susan

    Published 2013
    “…We found we could arrest NM in either of these two distinct oligomeric states with small molecules or crosslinking. The A11-reactive oligomers were more hydrophobic (as measured by Nile Red binding) and were highly toxic to neuronal cells, while OC-reactive oligomers were less hydrophobic and were not toxic. …”
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    Molecular analysis of antimalarial therapies : from drug development to mode of action by Dziekan, Jerzy Michal

    Published 2019
    “…We isolated and identified skullcapflavone-II and wogonin, two previously uncharacterised molecules with antimalarial properties from Scutellaria baicalensis plant extract and used CETSA to determine the candidate molecular targets for skullcapflavone-II, the more potent of the two substances. …”
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