Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney by Daneshmand, Ali, Mazumder, Aprotim, Allocca, Mariacarmela, Calvo, Jennifer A., Abolhassani, Nona, Jhun, Iny, Muthupalani, Sureshkumar, Ayata, Cenk, Ebrahimkhani, Mohammad Reza, Samson, Leona D

“…Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg) excises several DNA base lesions induced by the inflammation-associated RONS release that accompanies ischemia reperfusion (I/R). …”
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Microfluidic Platform for Combinatorial Synthesis and Optimization of Targeted Nanoparticles for Cancer Therapy by Valencia, Pedro M., Pridgen, Eric M., Rhee, Minsoung, Langer, Robert, Farokhzad, Omid C., Karnik, Rohit

“…Taking a nanoparticle (NP) from discovery to clinical translation has been slow compared to small molecules, in part by the lack of systems that enable their precise engineering and rapid optimization. …”
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Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues by Li, Cheri Yingjie, Stevens, Kelly R., Schwartz, Robert E., Alejandro, Brian S., Huang, Joanne H., Bhatia, Sangeeta N.

“…Interactions of engineered hepatic microtissues with drugs was characterized by flow cytometry, and yielded both induction of P450 enzymes in response to prototypic small molecules and drug–drug interactions that give rise to hepatotoxicity. …”
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Two different conformations in hepatitis C virus p7 protein account for proton transport and dye release by Gan, Siok Wan, Surya, Wahyu, Vararattanavech, Ardcharaporn, Torres, Jaume

“…However, the rationale for the dual ability of p7 to serve as an ion or proton channel in the infected cell, and to permeabilize membranes to large molecules like CF is not clear. We have recreated both activities in vitro, examining the conformation present in these assays using infrared spectroscopy. …”
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SSRP1 promotes colorectal cancer progression and is negatively regulated by miR‐28‐5p by Deng, Yunchao, Luo, Xu, Yu, Honggang, Ding, Qianshan, Xiang, Guoan, Wu, Wei, He, Ke, Guo, Qian, Chen, Jingdi, Zhang, Mengjiao, Huang, Kai, Yang, Dongmei, Wu, Lu

“…SSRP1 was knocked down and overexpressed in CRC cell lines, and its effects on proliferation, cell cycling, migration, invasion, cellular energy metabolism, apoptosis, chemotherapeutic drug sensitivity and cell phenotype‐related molecules were assessed. The growth of xenograft tumours in nude mice was also assessed. …”
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Enhancing antigen cross-presentation in human monocyte-derived dendritic cells by recruiting the intracellular Fc receptor TRIM21 by Ng, Patricia M. L., Kaliaperumal, Nivashini, Lee, Chia Yin, Chin, Wen Jie, Tan, Hwee Ching, Au, Veonice B., Goh, Angeline X.-H., Tan, Qiao Wen, Yeo, Darren S. G., Connolly, John E., Wang, Cheng-I

“…In APCs, peptides generated by proteasomes are loaded onto MHC class I molecules to stimulate CD8 T cell responses, which are crucial for effective immunity to pathogens. …”
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Tracking ultrafast bond dissociation dynamics at 0.1 Å resolution by femtosecond extreme ultraviolet absorption spectroscopy by Wei, Zhengrong, Tian, Li, Li, Jialin, Lu, Yunpeng, Yang, Minghui, Loh, Zhi-Heng

“…Our results suggest that femtosecond XUV absorption spectroscopy, in combination with ab initio simulations of XUV transition energies, can be used to resolve the ultrafast structural dynamics of large polyatomic molecules.…”
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Unique 3D flower-on-sheet nanostructure of NiCo LDHs : controllable microwave-assisted synthesis and its application for advanced supercapacitors by Zhou, Yanping, Li, Jing, Yang, Yang, Luo, Bin, Zhang, Xiong, Fong, Eileen, Chu, Wei, Huang, Kama

“…We propose that under microwave irradiation, EG molecules disperse the nuclei and facilitate the initial formation of 2D sheets. …”
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Smart nanomicelles with bacterial infection-responsive disassembly for selective antimicrobial applications by Pranantyo, Dicky, Kang, En-Tang, Chan-Park, Mary B.

“…At this low pH, the β-carboxylic amide bond of the anionic polypeptide gradually hydrolyzed to expose the initial cationic amine moieties, causing the NMs to ‘decompose’ into individual CS-PLL and ‘spill’ the cationic molecules which then disrupted and killed the bacteria. …”
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Supported lipid bilayer platform for characterizing the optimization of mixed monoglyceride nano-micelles by Yoon, Bo Kyeong, Park, Soohyun, Jackman, Joshua A., Cho, Nam-Joon

“…Our findings indicate that GML/GMC molecules self-assemble into ideally mixed nano-micelles and GML/GMC nano-micelles trigger membrane budding to varying extents depending on the GML/GMC molar ratio. …”
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Pilot deep RNA sequencing of worker blood samples from Singapore printing industry for occupational risk assessment by Guo, Nancy Lan, Bello, Dhimiter, Ye, Qing, Tagett, Rebecca, Chanetsa, Lucia, Singh, Dilpreet, Poh, Tuang Yeow, Setyawati, Magdiel Inggrid, Chotirmall, Sanjay Haresh, Ng, Kee Woei, Demokritou, Philip

“…In particular, the cell adhesion molecules (CAMs) was a top significantly perturbed pathway in blood samples from exposed workers compared with the office workers in both companies. …”
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Targeting mycobacterial F-ATP synthase C-terminal α subunit interaction motif on rotary subunit γ by Harikishore, Amaravadhi, Wong, Chui-Fann, Ragunathan, Priya, Litty, Dennis, Müller, Volker, Grüber, Gerhard

“…In this direction, our computational work has led to the development of an eight-featured α533-545 peptide pharmacophore, followed by database screening, molecular docking, and pose selection, resulting in eleven hit molecules. ATP synthesis inhibition assays using recombinant ATP synthase as well as mycobacterial inverted membrane vesicles show that one of the hits, AlMF1, inhibited the mycobacterial F-ATP synthase in a micromolar range. …”
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Feasibility and performance of a thin-film composite seawater reverse osmosis membrane fabricated on a highly porous microstructured support by Lim, Yu Jie, Lee, Jaewoo, Bae, Tae-Hyun, Torres, Jaume, Wang, Rong

“…This excellent performance is thought to stem from the HPμS support endowing a TFC membrane with comparable mechanical properties to that of existing support used for conventional SWRO membrane and shortened effective diffusion pathway of water molecules over the active layer. The robustness and enhanced mechanical strength of the TFC-HPμS membrane are attributed to its narrow and regularly arranged finger-like structure ensuring the even distribution of local stresses, thereby eliminating the presence of stress convergence points. …”
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Liquid-liquid phase separation of short histidine- and tyrosine-rich peptides: sequence specificity and molecular topology by Lim, Jessica, Kumar, Akshita, Low, Kimberly Jia Yi, Verma, Chandra Shekhar, Mu, Yuguang, Miserez, Ali, Pervushin, Konstantin

“…In addition, the analysis of nanoscale topologies may pave the way to understand how client molecules can be trapped within microdroplets, with direct implications for the encapsulation and controlled release of therapeutics for drug delivery applications.…”
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Dopamine-intercalated polyelectrolyte multilayered nanofiltration membranes: toward high permselectivity and ion-ion selectivity by Yang, Yang, Li, Ye, Goh, Kunli, Tan, Choon Hong, Wang, Rong

“…A three-step deposition was applied to the negatively charged PES substrate surface, following an alternate sequence of poly(allylamine hydrochloride) (PAH), dopamine (DA) and poly(sodium 4-styrenesulfonate) (PSS). The dopamine molecules were intercalated between the PAH and PSS layers to achieve a thinner thickness, higher hydrophilicity, smaller surface roughness and narrower pore size distribution. …”
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Simultaneous fractionation, desalination, and dye removal of dye/salt mixtures by carbon cloth-modified flow-electrode capacitive deionization by Tang, Kexin, Zheng, Han, Du, Penghui, Zhou, Kun

“…The removal/recovery of dyes from the carbon cloth strongly depends on the characteristics of dye molecules, the surface properties of the carbon cloth, and the local pH at the IEM/CC interfaces. …”
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Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents by Hegde, Pooja V., Aragaw, Wassihun W., Cole, Malcolm S., Jachak, Gorakhnath, Ragunathan, Priya, Sharma, Sachin, Harikishore, Amaravadhi, Grüber, Gerhard, Dick, Thomas, Aldrich, Courtney C.

“…All the analogs were evaluated for their whole cell antimycobacterial activity, and a few representative molecules were evaluated for their binding affinity, towards PanD, through isothermal titration calorimetry. …”
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Environmental calibration of coral luminescence as a proxy for terrigenous dissolved organic carbon concentration in tropical coastal oceans by Kaushal, Nikita, Tanzil, Jani T. I., Zhou, Yongli, Ong, Maria Rosabelle, Goodkin, Nathalie F., Martin, Patrick

“…Corals incorporate fluorescent tDOM molecules from the chromophoric dissolved organic matter (CDOM) pool in their skeletons. …”
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Liquid-liquid extraction: thermodynamics-kinetics driven processes explored by microfluidics by Olivier, Fabien, Maurice, Ange, Meyer, Daniel, Gabriel, Jean-Christophe P.

“…Once collected and processed, the kinetics show two distinct behaviors of these two metallic elements: depending on the temperature, Fe could display a very slow extraction profile when compared to Yb. illustrer les fortes différences cinétiques d'extraction de l'ytterbium (Yb) et du fer (Fe), deux éléments pointés pour leur efficacité d'extraction très différente en raison de différentes forces moléculaires rivalisant avec la complexation lorsque des modificateurs sont mis en jeu avec des molécules extractantes. Une fois collectées et traitées, les données cinétiques montrent deux comportements distincts concernant ces deux éléments métalliques: selon la température, Fe peut présenter un profil d'extraction très lent par rapport à Yb.…”
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Protein nanoparticle cellular fate and responses in murine macrophages by Ravishankar, Samyukta, Nedumaran, Anu Maashaa, Gautam, Archana, Ng, Kee Woei, Czarny, Bertrand, Lim, Sierin

“…This knowledge is crucial for the effective translation of these engineered molecules for theranostic applications. In this work, we performed an in-depth study on the intracellular fate and relevant immune responses of a model organic NP, Archaeoglobus fulgidus ferritin, in murine macrophage (RAW264.7) cells. …”
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