Molecular responses during chemotherapy in acute myeloid leukemias in predicting poor-response to standard chemotherapy. por Abdullah, Maha, Cheong, Soon Keng, Leong, Chooi Fun, Seow, Heng Fong

“…These cellular molecules may also be potential targets for alternative therapy.…”
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Linear Thermodynamics of Rodlike DNA Filtration por Li, Zirui, Liu, Guirong, Chen, Yuzong, Wang, Jian-Sheng, Hadjiconstantinou, Nicolas, Cheng, Y., Han, J.

“…Linear thermodynamics transportation theory is employed to study filtration of rodlike DNA molecules. Using the repeated nanoarray consisting of alternate deep and shallow regions, it is demonstrated that the complex partitioning of rodlike DNA molecules of different lengths can be described by traditional transport theory with the configurational entropy properly quantified. …”
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Open-access microcavities for chemical sensing por Vallance, C, Trichet, A, James, D, Dolan, P, Smith, J

“…The extremely small mode volumes within an optical microcavity allow very small numbers of molecules to be probed: our current best detection limits for refractive index and absorption sensing are around 10(5) and 10(2) molecules, respectively, with scope for further improvements in the future.…”

Aspects of native proteins are retained in vacuum. por Ruotolo, B, Robinson, C

“…This remains an intriguing phenomenon, given the importance placed on water molecules in stabilizing protein structure. As a consequence, the overall structure of protein molecules and their complexes in the gas phase continues to stimulate much research. …”

Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach. por Beswick, P, Blackaby, A, Bountra, C, Brown, T, Browning, K, Campbell, I, Corfield, J, Gleave, R, Guntrip, S, Hall, R, Hindley, S, Lambeth, P, Lucas, F, Mathews, N, Naylor, A, Player, H, Price, H, Sidebottom, P, Taylor, N, Webb, G, Wiseman, J

“…Frequently approaches to reduce lipophilicity through introduction of polar functionality is hampered by highly challenging chemistry to prepare key molecules. We have complemented traditional synthetic chemistry with a biotransformations approach which efficiently provided access to an array of key target molecules.…”

Antigens on the Plasmodium falciparum infected erythrocyte surface are parasite derived: a reply. por Newbold, C, Marsh, K

“…The stable characteristics of infected cells may in part stem from parasite-induced changes in band 3 molecules, thus explaining some of the cytoadherence properties of uninfected, but abnormal cells (as in sickle-cell disease and diabetes). …”

Rheumatoid arthritis: Pathogenic mechanisms and therapeutic targets por Taylor, P, Feldmann, M

“…These include pro-inflammatory cytokines, inflammatory cells and accessory molecules. © 2004 Elsevier Ltd. All rights reserved.…”

1 `-Methyl-2-oxo-5 `-phenylspiro[indoline-3,3 `-pyrrolidine]-4 `,4 `-dicarbonitrile por Nabid, M.R., Rezaei, S.J.T., Fazaeli, Y., Ng, S.W.

“…In the crystal, adjacent molecules are linked by N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds.…”

4-Aminopyridinium-3-sulfonate monohydrate por Zhu, Zhi Biao, Gao, Shan, Ng, Seik Weng

“…The H and non-H atoms of both zwitterions lie on a mirror plane except for one sulfonate O atom. The water molecules are also situated on a mirror plane. In the crystal, the zwitterions and water molecules are linked by O -H⋯O and N -H⋯O hydrogen bonds, generating a threedimensional network.…”

1H-Benzimidazol-2-ylmethyl phenyl ether por Hassan, N.D., Tajuddin, Hairul Anuar, Abdullah, Z., Ng, S.W.

“…There are two molecules in the asymmetric unit of the title compound, C(14)H(10)N(2)O: the dihedral angles between their aromatic ring planes are 47.4 (4) and 46.8 (3)degrees. …”
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What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? por Ratti, Francesca, Magarini, Maurizio, Del Vecchio, Domitilla

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Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds por Chan, Philip Wai Hong, Tejo, Ciputra, Sim, Xiao Rong, Lee, Bo Ra, Ayers, Benjamin James, Leung, Chung-Hang, Ma, Dik-Lung

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Optimisation of modRNA gene delivery and the FUCCI mouse model for cardiomyocyte proliferation por Hew, Rachel Jia Yi

“…After optimizing modRNA production to ensure efficient transfection, we used these modRNA molecules to transfect isolated FUCCI cardiomyocytes. …”
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Investigation on the mechanism of amyloid beta peptides oligomerization and the process for its inhibition por Zhao, Li Na

“…They are easily attached to membrane and other molecules. Thus, it is difficult to study them purely based on conventional experimental approaches. …”
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Amine-Functionalized ZnO Nanosheets for Efficient CO2 Capture and Photoreduction por Liao, Yusen, Hu, Zhaoning, Gu, Quan, Xue, Can

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Antiviral Activities of Algal-Based Sulfated Polysaccharides por Panggabean, Jonathan Ardhianto, Adiguna, Sya’ban Putra, Rahmawati, Siti Irma, Ahmadi, Peni, Zainuddin, Elmi Nurhaidah, Bayu, Asep, Putra, Masteria Yunovilsa

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Polymorphism of a high molecular weight schizont antigen of the human malaria parasite Plasmodium falciparum. por McBride, J, Newbold, C, Anand, R

“…(f) These polymorphic molecules are closely related to a previously described schizont protein of P. falciparum that is posttranslationally cleaved into fragments located on the merozoite surface. …”

Hydrogen storage in ion-exchanged zeolites por Langmi, H, Book, D, Walton, A, Johnson, SR, Al-Mamouri, M, Speight, J, Edwards, P, Harris, I, Anderson, P

“…Volumetric storage densities of up to 31.0 kg H 2/m3 (143 H2 molecules/unit cell) and 30.2 kg H2/m3 (144 H2 molecules/unit cell) were achieved for CaX and KX, respectively. © 2005 Elsevier B.V. …”

The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells. por Young, N, Waller, E, Patel, R, Roghanian, A, Austyn, J, Trowsdale, J

“…They ubiquitously express members of the LILR (ILT, LIR, CD85) family of molecules, some of which recognize self-HLA molecules, but little is known of their possible functions in DC biology. …”

Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. por Karadimitris, A, Gadola, S, Altamirano, M, Brown, D, Woolfson, A, Klenerman, P, Chen, J, Koezuka, Y, Roberts, I, Price, D, Dusheiko, G, Milstein, C, Fersht, A, Luzzatto, L, Cerundolo, V

“…CD1 molecules are specialized in presenting lipids to T lymphocytes, but identification and isolation of CD1-restricted lipid specific T cells has been hampered by the lack of reliable and sensitive techniques. …”