Responses of defect-rich Zr-based metal–organic frameworks toward NH3 adsorption by Yoskamtorn, T, Zhao, P, Wu, X-P, Purchase, K, Orlandi, F, Manuel, P, Taylor, J, Li, Y, Day, S, Ye, L, Tang, CC, Zhao, Y, Tsang, SCE

“…We also demonstrate that the degree of structural flexibility of the functional linkers can critically be affected by the type and quantity of the small guest molecules. This strikes a delicate control in material properties at the molecular level.…”

Structure and evolutionary history of DISC1. by Sanchez-Pulido, L, Ponting, C

“…Even eukaryotic organisms lacking nervous systems contain homologues of many key signalling molecules of animal neurons implying that human cognition derives, in part, from modifications of ancestral molecules and complexes. …”

Interactions between calcium release pathways: multiple messengers and multiple stores. by Galione, A, Churchill, G

“…These molecules have distinct structures and act on specific Ca(2+) release mechanisms. …”

Interaction between host complement and mosquito-midgut-stage Plasmodium berghei. by Margos, G, Navarette, S, Butcher, G, Davies, A, Willers, C, Sinden, R, Lachmann, P

“…Ongoing research aims to identify these molecules.…”

Microsatellite analysis of the APC gene and immunoexpression of E-cadherin, catenin, and tubulin in esophageal squamous cell carcinoma. by Nair, K, Naidoo, R, Chetty, R

“…The understanding of the status of these molecules in ESSC may provide novel markers that could impact on management of the disease. …”

Molecular dynamics simulations of water within models of ion channels by Breed, J, Sankararamakrishnan, R, Kerr, I, Sansom, M

“…The transbilayer pores formed by ion channel proteins contain extended columns of water molecules. The dynamic properties of such waters have been suggested to differ from those of water in its bulk state. …”

A genomic DNA reporter screen identifies squalene synthase inhibitors which act cooperatively with statins to upregulate the low-density lipoprotein receptor by Kerr, A, Tam, L, Hale, A, Cioroch, M, Douglas, G, Agkatsev, S, Hibbit, O, Mason, J, Holt-Martyn, J, Bataille, C, Wynne, G, Channon, K, Russell, A, Wade-Martins, R

“…Here we identify a series of small molecules from a genomic DNA reporter screen which upregulate the LDLR in mouse and human liver cell lines at nanomolar potencies (EC50: 39 nM). …”

A solute gradient in the tear meniscus. I. A hypothesis to explain Marx's line. by Bron, A, Yokoi, N, Gaffney, E, Tiffany, J

“…We hypothesize that this stimulates a high epithelial cell turnover at this site, incomplete epithelial maturation, and a failure to express key molecules such as MUC 16 and galectin-3, which, with the tight junctions between surface epithelial cells, are necessary to seal the ocular surface and prevent penetration of dyes and other molecules into the epithelium. …”

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. by Lühder, F, Huang, Y, Dennehy, K, Guntermann, C, Müller, I, Winkler, E, Kerkau, T, Ikemizu, S, Davis, S, Hanke, T, Hünig, T

“…Moreover, mouse CD28 molecules engineered to express the rat or human C"D loop sequences activated T cell hybridomas without TCR ligation when cross-linked by superagonistic mAbs. …”

Transient triglyceridemia in healthy normolipidemic men increases cellular processing of large very low density lipoproteins by fibroblasts in vitro. by Björkegren, J, Karpe, F, Vitols, S, Tornvall, P, Hamsten, A

“…The increase in number of apoE molecules per large VLDL particle correlated positively and significantly with the increase in the capacity of large VLDL to inhibit LDL binding to the LDL receptor (r = 0.76, P = 0.01, n = 10). …”

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci by Tragante, V, Tragante, V, Barnes, MR, Ganesh, S, Lanktree, M, Guo, W, Franceschini, N, Smith, E, Johnson, T, Holmes, M, Padmanabhan, S, Karczewski, K, Almoguera, B, Barnard, J, Baumert, J, Chang, Y, Elbers, C, Elbers, C, Farrall, M, Farrall, M, Fischer, M, Gaunt, T, Gho, J, Gieger, C, Goel, A

“…Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. …”

Multiscale molecular dynamics simulations of lipid interactions with P-glycoprotein in a complex membrane. by Domicevica, L, Koldsø, H, Biggin, P

“…P-glycoprotein (P-gp) can transport a wide range of very different hydrophobic organic molecules across the membrane. Its ability to extrude molecules from the cell creates delivery problems for drugs that target proteins in the central nervous system (CNS) and also causes drug-resistance in many forms of cancer. …”

Towards stabilised cyclocarbons by Kohn, DR

“…</p> <p>Chapter 1 reviews the history of carbon-rich molecules, experimental and theoretical studies of cyclocarbons and the concept of stabilising carbon chains via encapsulation.…”

Cold chemistry with electronically excited Ca+ Coulomb crystals. by Gingell, A, Bell, M, Oldham, J, Softley, T, Harvey, J

“…Rate constants for chemical reactions of laser-cooled Ca(+) ions and neutral polar molecules (CH(3)F, CH(2)F(2), or CH(3)Cl) have been measured at low collision energies (<e(coll)>/k(B)=5-243 K). …”

Overproduction of proteorhodopsin enhances long-term viability of Escherichia coli by Song, Y, Cartron, M, Jackson, P, Davison, P, Dickman, M, Zhu, D, Huang, W, Hunter, C

“…Quantitative mass spectrometry shows that E. coli, exogenously supplied with the retinal cofactor, assembles as many as 187,000 holo-PR molecules per cell, accounting for approximately 47% of the membrane area; even cells with no retinal synthesise ∼148,000 apo-PR molecules per cell. …”

Complexity-generating cascade reactions by Garrec, K

“…The synthesis of unusual spirocyclic molecules is reported.</p> <p>In tandem with the radical cyclisations, anionic cyclisations were briefly investigated and are reported in <b>Chapter 4</b>.…”

The MUSCLES Treasury Survey. iii. X-ray to infrared spectra of 11 M and K stars hosting planets by P. Loyd, R, France, K, Youngblood, A, Schneider, C, Brown, A, Hu, R, Linsky, J, Froning, C, Redfield, S, Rugheimer, S, Tian, F

“…Using these SEDs, we computed the photo-dissociation rates of several molecules prevalent in planetary atmospheres when exposed to each star’s unattenuated flux (“unshielded” photodissociation rates) and found that rates differ among stars by over an order of magnitude for most molecules. …”

Independent nucleation and heterogeneous assembly of structure during folding of equine lysozyme. by Morozova-Roche, L, Jones, J, Noppe, W, Dobson, C

“…They reveal that an intermediate having persistent structure within three of the four helices of the alpha-domain of the protein is formed for the whole population of molecules within 4 ms. Subsequent to this event, however, the hydrogen exchange protection kinetics are complex and highly heterogeneous. …”

Generalized binomial tau-leap method for biochemical kinetics incorporating both delay and intrinsic noise by Leier, A, Marquez-Lago, T, Burrage, K

“…However, for systems with widely varying reaction rate constants or large numbers of molecules, the simulation time steps of both the stochastic simulation algorithm (SSA) and the DSSA can become very small causing considerable computational overheads. …”

Comparison of the solution structures of intramolecular DNA triple helices containing adjacent and non-adjacent CG.C+ triplets. by Asensio, J, Brown, T, Lane, A

“…The global conformations of the two molecules determined with &gt;19 restraints per residue are very similar (RMSD = 0.96 A). …”