Isolation, molecular and biomedical characterisation of endophytes from selected medicinal plants by Chin, Elaine Jinfeng

“…However, with every new bioactive molecule reported from a plant source, there follows reports of endangered status or even extinction of a medicinally important plant due to over-harvesting. …”
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Identification of thermostable peptide markers in meats using gel-based fractionation coupled with mass spectrometry by Mat Junoh, Nadiah

“…The genomic approach is another commonly used method but suffers from potential deoxyribonucleic acid (DNA) contamination from other organism and due to its structure, DNA molecule is less resistant to heat treatment. The limitation of these methods may lead to a false positive result in detection analysis. …”
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Identification and characterisation of thiamine pyrophosphate (TPP) riboswitch in Elaeis guineensis by Subki, Atiqah, Ho, Chai Ling, Ismail, Nur Farhah Nabihan, Zainal Abidin, Aisamuddin Ardi, Yusof, Zetty Norhana Balia

“…Recent studies suggest the importance of signalling molecules in plants in coping against stresses, which includes thiamine (vitamin B1). …”
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Development of a new class of diarylpentadienone analogues as anti-diabetic agents by Abdullah, Maryam Aisyah

“…Whereas for DPP-4 inhibition activity, none of the synthesized molecules showed a comparable suppression to the standard drug, sitagliptin, (IC50 = 0.07 ± 0.1 μM). …”
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Microscopic Insight Of Molecularly Imprinted Sol-Gel Matrix For Creatinine-Recognised Biosensor by Ang, Qian Yee

“…First, the host-guest chemistry is studied in detail, in terms of intermolecular interactions, to elucidate the recognition behaviour of target molecule (template), creatinine (Cre) by MIP. Cre is a spontaneous and non-enzymatic degradation end product of creatine (Cr) or phosphocreatine metabolism in vertebrates, which serves as a reliable biomarker in assessing renal, thyroid and muscular dysfunction. …”
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Adsorption behaviour of molecularly imprinted-beta-cyclodextrin polymers prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization for selective recognitio... by Asman, Saliza

“…Molecularly imprinted polymers (MIPs) are kinds of powerful materials with promising selective molecule recognition abilities. However, the conventional MIPs have relatively low binding capacity. …”
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Utilization of De-Oiled Spent Bleaching Clay as a Catalyst for Transesterification of Palm Olein by Rehan, Zainol Abidin, Gaanty Pragas, Maniam, Mohd Hasbi, Ab. Rahim

“…The reaction involves the breakage of the glycerol structure and exchanges of alkyl group between the alcohol and ester part of the triglycerides molecule; as such, the reaction is known as transesterification (Alba-Rubio et al., 2010). …”
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Identification of usnic acid derivatives as new antiviral agents via virtual screening on dengue, influenza A and avian influenza A by Miah, Roney

“…Further filtering by ADME prediction tools and drug-likeness prediction of forty-one, four and five compounds from DENV, Influenza and Avian Influenza, respectively, resulted in seven hit compounds for DENV, two hit compounds for Influenza and two compounds for Avian Influenza virus, respectively. The lead molecule, called compound-362, compound-4, and compound-5, was discovered after screening the hit compounds against DENV, Influenza, and Avian Influenza utilising the cytochrome P450 enzyme. …”
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Biofabrication of choroid-retina tissue construct for modelling of age-related macular degeneration disease by Tan, Edgar Yong Sheng

“…The experimental results indicated that the endothelial cells (HUVECs) was able to vascularise and was functional as demonstrated by the production of platelet endothelial cell adhesion molecule-1 biomarkers (CD31) and vWF (von Willebrand Factor). …”
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Targeting the bacterial epitranscriptome for antibiotic development : discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors by Zhong, Wenhe, Koay, Ann, Ngo, Anna, Li, Yan, Nah, Qianhui, Wong, Yee Hwa, Chionh, Yok Hian, Ng, Hui Qi, Koh-Stenta, Xiaoying, Poulsen, Anders, Foo, Klement, McBee, Megan, Choong, Meng Ling, El Sahili, Abbas, Kang, Congbao, Matter, Alex, Lescar, Julien, Hill, Jeffrey, Dedon, Peter

“…Here we developed and applied a widely applicable, radioactivity-free, bioluminescence-based high-throughput screen (HTS) against 116350 compounds from structurally diverse small-molecule libraries to identify inhibitors of Pseudomonas aeruginosa TrmD ( PaTrmD). …”
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TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus by Jayaraman, Anusha, Htike, Thein Than, James, Rachel, Picon, Carmen, Reynolds, Richard

“…Exposure of human iPSC-derived glutamatergic neurons to TNF increased necroptotic cell death when apoptosis was inhibited, which was significantly reversed by small molecule inhibitors of RIPK1, RIPK3, and MLKL. In the post-mortem AD brain and in human iPSC neurons, in response to TNF, we show evidence of altered expression of proteins of the ESCRT III complex, which has been recently suggested as an antagonist of necroptosis and a possible mechanism by which cells can survive after necroptosis has been triggered. …”
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The steroidal lactone withaferin A impedes T-cell motility by inhibiting the kinase ZAP70 and subsequent kinome signaling by Mobashar Hussain Urf Turabe Fazil, Chirumamilla, Chandra Sekhar, Perez-Novo, Claudina, Wong, Brandon Han Siang, Kumar, Sunil, Sze, Siu Kwan, Berghe, Wim Vanden, Verma, Navin Kumar

“…We found that WFA dose-dependently (within the concentration range of 0.3-1.25 μM) inhibited the ability of human T-cells to migrate via cross-linking of the lymphocyte function-associated antigen-1 (LFA-1) integrin with its ligand, intercellular adhesion molecule 1 (ICAM-1). Coimmunoprecipitation of WFA interacting proteins and subsequent tandem mass spectrometry identified a WFA-interactome consisting of 273 proteins in motile T-cells. …”
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Strategies to improve the performance of platinum-based electrocatalysis from the atomic scale by Guo, Shasha

“…To gain insight into this phenomenon in HER, an in-situ single-molecule total internal reflection microscopy/micro-electrochemical platform is developed. …”
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Methanol electrochemical refinery towards formate by Meng, Fanxu

“…Iron-substituted lanthanum cobaltite perovskites, which have shown excellent performance in other electrocatalytic reactions, such as oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and other small molecule oxidation reactions), are examined for the methanol e-refinery reaction. …”
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NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor by Shi, Zhaoqing, Luo, Miaomiao, Huang, Qili, Ding, Chendi, Wang, Wenyan, Wu, Yinglong, Luo, Jingjing, Lin, Chuchu, Chen, Ting, Zeng, Xiaowei, Mei, Lin, Zhao, Yanli, Chen, Hongzhong

“…Here we report a bridging strategy that unfastens HSA to polypeptide chains and subsequently crosslinks these chains by a bridge-like molecule (BPY-Mal2) to afford the HSA reassemblies formulation (BPY@HSA) with enhanced loading capacity, endowing the BPY@HSA with uniformed size, high photothermal efficacy, and favorable therapeutic features. …”
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Solvent-templated methylammonium-based Ruddlesden–Popper perovskites with short interlayer distances by Zhumekenov, Ayan A., Li, Yongxin, Zhou, Yifan, Yantara, Natalia, Kanwat, Anil, Febriansyah, Benny, Tay, Darrell Jun Jie, Abuzeid, Hesham R., Tay, Yeow Boon, Miftahullatif, Emha Bayu, Hippalgaonkar, Kedar, Pullarkat, Sumod A., Yin, Jun, Mathews, Nripan

“…This work exemplifies the unconventional role of the non-charged solvent molecule in templating the 2D perovskite structure.…”
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Treatment of sarcopenia by antagonists of myostatin by Anissa Anindya Widjaja

“…From kinetic experiments, we found that 15 out of the 31 molecules bind with high specificity to myostatin and with expected affinity for small molecules. …”
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c-di-GMP distribution across single and mixed species biofilms by Harikrishnan A. S. Nair

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The electro-oxidation of C1, C2 and C3 saturated alcohols on nickel-cobalt oxides by Sun, Shengnan

“…The electro-oxidation of small molecules is attracting an increasing interest in many fields like water splitting, fuel cell, environmental protection, and fine chemical industry. …”
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Self-assembled biomimetic architectures : protein-polymer conjugates and lipid-polymer hybrids for biomedical applications by Khan, Amit Kumar

“…The experimental results reveal that such vesicles possess similar properties (size, bilayer thickness, and small molecule encapsulation capability) to vesicular membranes at the nanoscale. …”
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