Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents by Negar Maafi, Abdullah Al Mamun, Ondřej Janďourek, Jana Maříková, Kateřina Breiterová, Adéla Diepoltová, Klára Konečná, Anna Hošťálková, Daniela Hulcová, Jiří Kuneš, Eliška Kohelová, Darja Koutová, Marcela Šafratová, Lucie Nováková, Lucie Cahlíková

“…The semisynthetic derivatives of AAs were screened for their in vitro antimycobacterial activity against <i>Mycobacterium tuberculosis</i> H37Ra and two other mycobacterial strains (<i>M. aurum</i>, <i>M. smegmatis</i>) using a modified Microplate Alamar Blue Assay. …”
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A multistage Sendai virus vaccine incorporating latency-associated antigens induces protection against acute and latent tuberculosis by Zhidong Hu, Jingxian Xia, Juan Wu, Huimin Zhao, Ping Ji, Ling Gu, Wenfei Gu, Zhenyan Chen, Jinchuan Xu, Xuejiao Huang, Jian Ma, Anke Chen, Jixi Li, Tsugumine Shu, Xiao-Yong Fan

“…ABSTRACTOne-quarter of the world’s population is infected with Mycobacterium tuberculosis (Mtb). After initial exposure, more immune-competent persons develop asymptomatic latent tuberculosis infection (LTBI) but not active diseases, creates an extensive reservoir at risk of developing active tuberculosis. …”
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Genitourinary tuberculosis in the structure of autopsy morphological findings in deceased patients at the late stages of HIV infection by L. V. Puzyreva, A. V. Mordyk, S. A. Rudenko

“…Prostate TB was confirmed by analysis of expressed prostatic secretion on Mycobacterium tuberculosis (2.6 ± 1.5%) and was combined with kidney TB. …”
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IDOSOS PORTADORES DO HIV COM TUBERCULOSE NO BRASIL: ANÁLISE EPIDEMIOLÓGICA DOS ÚLTIMOS OITO ANOS by Carolina Lopes Bordinassi, Luiza Barreto de Carvalho, Fernanda Rocha Lacerda, Higor Braga Cartaxo

“…Neste sentido, tem-se observado um aumento de casos de HIV nesta população, bem como de seus agravos, como a coinfecção pelo Mycobacterium tuberculosis. O objetivo do presente trabalho é analisar aspectos epidemiológicos da incidência e mortalidade de idosos portadores de HIV com tuberculose no Brasil. …”
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Mucosal and systemic antigen-specific antibody responses correlate with protection against active tuberculosis in nonhuman primatesResearch in context by Elise Ishida, Devin T. Corrigan, Tingting Chen, Yanyan Liu, Ryung S. Kim, Lusheng Song, Tara M. Rutledge, D Mitchell Magee, Joshua LaBaer, Todd L. Lowary, Philana Ling Lin, Jacqueline M. Achkar

“…The main objective of this study was to identify antigen-specific airway and systemic immunoglobulin isotype responses associated with the outcome of controlled latent Mycobacterium tuberculosis (Mtb) infection (LTBI) versus uncontrolled infection (TB) in nonhuman primates. …”
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Evaluation of Sulfasalazine as an Adjunctive Therapy in Treating Pulmonary Pre-XDR-TB: Efficacy, Safety, and Treatment Implication by Fu L, Wang W, Xiong J, Zhang P, Li H, Zhang X, Liang H, Yang Q, Wang Z, Chen X, Deng G, Cai Y, Tang S

“…Sulfasalazine (SASP), by targeting the amino acid transport system xc (xCT), potentially reduces the intracellular Mycobacterium tuberculosis load and mitigates lung pathology, positioning it as a promising TB HDT agent. …”
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Comparative analysis of tuberculin and defined antigen skin tests for detection of bovine tuberculosis in buffaloes (Bubalus bubalis) in Haryana state, India by Mohit Kumar, Tarun Kumar, Babu Lal Jangir, Mahavir Singh, Devan Arora, Yogesh Bangar, Andrew Conlan, Martin Vordermeier, Douwe Bakker, S. M. Byregowda, Sreenidhi Srinivasan, Vivek Kapur, Naresh Jindal

“…Abstract Background Bovine tuberculosis (bTB) is a chronic disease that results from infection with any member of the Mycobacterium tuberculosis complex. Infected animals are typically diagnosed with tuberculin-based intradermal skin tests according to World Organization of Animal Health which are presently in use. …”
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Integrated bioinformatics analysis of dendritic cells hub genes reveal potential early tuberculosis diagnostic markers by Xiao Wu, Kewei Liu, Shanshan Li, Weicong Ren, Wei Wang, Yuanyuan Shang, Fuzhen Zhang, Yingying Huang, Yu Pang, Mengqiu Gao

“…Abstract Background Dendritic cells (DCs) are most potent antigen-processing cells and play key roles in host defense against Mycobacterium tuberculosis (MTB) infection. In this study, hub genes in DCs during MTB infection were first investigated using bioinformatics approaches and further validated in Monocyte-derived DCs. …”
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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway [version 1; referees: 2 approved, 1 approved with reservations] by Paul Fineran, Emyr Lloyd-Evans, Nathan A. Lack, Nick Platt, Lianne C. Davis, Anthony J. Morgan, Doris Höglinger, Raju Venkata V. Tatituri, Simon Clark, Ian M. Williams, Patricia Tynan, Nada Al Eisa, Evgeniya Nazarova, Ann Williams, Antony Galione, Daniel S. Ory, Gurdyal S. Besra, David G. Russell, Michael B. Brenner, Edith Sim, Frances M. Platt

“…The ability to prevent phagosome-lysosome fusion is a key mechanism by which intracellular mycobacteria, including Mycobacterium tuberculosis, achieve long-term persistence within host cells. …”
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The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result [version 2; peer review: 2 approved, 1 approved with reserv... by Yasmeen Hanifa, Violet N. Chihota, Katherine L. Fielding, Salome Charalambous, Lungiswa Adonis, Alan Karstaedt, Nicola Foster, Mark P. Nicol, Kerrigan McCarthy, Edina Sinanovic, Nontobeko T. Ndlovu, Wendy Stevens, Faieza Sahid, Alison D. Grant, Gavin J. Churchyard, Anna Vassall

“…We defined TB as “confirmed” if Xpert, line probe assay or Mycobacterium tuberculosis culture within six months of enrolment were positive, and “clinical” if TB treatment was started without microbiological confirmation. …”
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Temporal genome-wide fitness analysis of Mycobacterium marinum during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells by Louise H. Lefrançois, Jahn Nitschke, Huihai Wu, Gaël Panis, Julien Prados, Rachel E. Butler, Tom A. Mendum, Nabil Hanna, Graham R. Stewart, Thierry Soldati

“…A key feature of pathogenesis, conserved between the human pathogen Mycobacterium tuberculosis and the model pathogen Mycobacterium marinum, is the metabolic switch to lipid catabolism and altered expression of virulence genes at different stages of infection. …”
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The Use of Mesenchymal Stem Cells in the Complex Treatment of Kidney Tuberculosis (Experimental Study) by Alexander N. Muraviov, Tatiana I. Vinogradova, Anna N. Remezova, Boris M. Ariel, Anna A. Gorelova, Nadezhda V. Orlova, Natalia M. Yudintceva, Diljara S. Esmedliaeva, Marina E. Dyakova, Marine Z. Dogonadze, Natalia V. Zabolotnykh, Irina A. Garapach, Olga S. Maslak, Yuri A. Kirillov, Sergei E. Timofeev, Yulia S. Krylova, Petr K. Yablonskiy

“…Methods: To simulate kidney tuberculosis, a suspension of the standard strain Mycobacterium tuberculosis H37Rv (10⁶ CFU) was used, which was injected into the cortical layer of the lower pole parenchyma of the left kidney under ultrasound control in rabbits. …”
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Infecciones en la unidad de cuidados intensivos del Hospital Oncológico SOLCA-Quito by Alba González, Marcelo Castelo, Karina Marín, Henry Caballero, Freddy Trujillo

“…Hubo un paciente con Mycobacterium Tuberculosis. La resistencia antibiótica para estas bacterias fue alta: 57,1% para E coli, 66,6% para E. …”
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Antimicrobial Potential of Betulinic Acid and Investigation of the Mechanism of Action against Nuclear and Metabolic Enzymes with Molecular Modeling by Gabriela Cristina Soares Rodrigues, Mayara dos Santos Maia, Thalisson Amorim de Souza, Edeltrudes de Oliveira Lima, Luiz Eduardo Carneiro Gomes dos Santos, Shellygton Lima Silva, Marcelo Sobral da Silva, José Maria Barbosa Filho, Valnês da Silva Rodrigues Junior, Luciana Scotti, Marcus Tullius Scotti

“…Among the 12 species (<i>Staphylococcus aureus</i>, <i>S. epidermidis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, <i>Mycobacterium tuberculosis</i>, <i>Candida albicans</i>, <i>C. tropicalis</i>, <i>C. glabrata</i>, <i>Aspergillus flavus</i>, <i>Penicillium citrinum</i>, <i>Trichophyton rubrum</i>, and <i>Microsporum canis)</i> investigated, 9 (75%) inhibited growth at a concentration of 561 µM and 1 at a concentration of 100 µM. …”
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Exploring <i>Micromonospora</i> as Phocoenamicins Producers by Maria Kokkini, Cristina González Heredia, Daniel Oves-Costales, Mercedes de la Cruz, Pilar Sánchez, Jesús Martín, Francisca Vicente, Olga Genilloud, Fernando Reyes

“…Using an OSMAC approach, all the strains were cultivated in 10 different media each, resulting in 270 fermentations, whose extracts were analyzed by LC-HRMS and subjected to High-throughput screening (HTS) against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), <i>Mycobacterium tuberculosis</i> H37Ra and <i>Mycobacterium bovis</i>. …”
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Graphene Oxide-Linezolid Combination as Potential New Anti-Tuberculosis Treatment by Flavio De Maio, Valentina Palmieri, Giulia Santarelli, Giordano Perini, Alessandro Salustri, Ivana Palucci, Michela Sali, Jacopo Gervasoni, Aniello Primiano, Gabriele Ciasca, Maurizio Sanguinetti, Marco De Spirito, Giovanni Delogu, Massimiliano Papi

“…Tuberculosis (TB) remains one of the most alarming worldwide infectious diseases and there is an urgent need for new drugs and treatments, particularly for the emergence and spread of drug-resistant <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) strains. New nanotechnologies based on carbon nanomaterials are now being considered to improve anti-TB treatments, and graphene oxide (GO) showed interesting properties as an anti-TB drug. …”
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Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population by Mingwu Zhang, Zhengwei Liu, Yelei Zhu, Kunyang Wu, Lin Zhou, Ying Peng, Junhang Pan, Bin Chen, Xiaomeng Wang, Songhua Chen

“…Abstract Background Pulmonary tuberculosis (PTB) is a common infectious disease caused by mycobacterium tuberculosis (MTB) and the present study aims to explore the associations of genetic variants within tyrosine kinases 2 (TYK2) with PTB incidence. …”
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Methylprednisolone Promotes <i>Mycobacterium smegmatis</i> Survival in Macrophages through NF-κB/DUSP1 Pathway by Anlong Li, Yonglin He, Chun Yang, Nan Lu, Jiajia Bao, Sijia Gao, Felycia Fernanda Hosyanto, Xintong He, Huichao Fu, Huajian Yan, Ningyu Ding, Lei Xu

“…Background: <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>) is the causative agent of tuberculosis. …”
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PERFIL SOCIODEMOGRÁFICO DO ABANDONO AO TRATAMENTO DA TUBERCULOSE NO BRASIL (2013-2022) by Hélio Cássio Silva Guimarães, Anderson Fraga Santos Dias, Murilo Figueiredo Nogueira Santos, Nadson Brasil dos Santos do Rego, Rafael Lopes Sampaio, Juliana Fraga Vasconcelos

“…Introdução/objetivo: A tuberculose é uma doença infecciosa causada pela bactéria Mycobacterium tuberculosis, que afeta principalmente os pulmões. …”
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In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of <i>M. tuberculosis</i> Polyketide Synthase 13 by Ali Irfan, Shah Faisal, Ameer Fawad Zahoor, Razia Noreen, Sami A. Al-Hussain, Burak Tuzun, Rakshanda Javaid, Ahmed A. Elhenawy, Magdi E. A. Zaki, Sajjad Ahmad, Magda H. Abdellattif

“…This virtual screening was carried out to discover and assess the chemotherapeutic efficacy of <b>BF1–BF16</b> structural motifs as <i>Mycobacterium tuberculosis</i> polyketide synthase 13 (Mtb Pks13) enzyme inhibitors. …”
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