Exploring TSPAN4 promoter methylation as a diagnostic biomarker for tuberculosis by Jiahao Zhang, Jiahao Zhang, Jiahao Zhang, Jilong Chen, Jilong Chen, Jilong Chen, Yan Zhang, Yan Zhang, Yan Zhang, Liuchi Chen, Liuchi Chen, Liuchi Chen, Weiwei Mo, Weiwei Mo, Weiwei Mo, Qianting Yang, Qianting Yang, Mingxia Zhang, Mingxia Zhang, Haiying Liu, Haiying Liu, Haiying Liu

“…Background:Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a persistent infectious disease threatening human health. …”
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Efficacy and safety of levilimab in combination with methotrexate in patients with active rheumatoid arthritis: 56-week results of phase III randomized double-blind placebo-control... by V. I. Mazurov, A. M. Lila, M. A. Korolev, A. M. Prystrom, A. V. Kundzer, N. F. Soroka, A. A. Kastanayan, T. V. Povarova, T. V. Plaksina, O. V. Antipova, D. G. Krechikova, S. A. Smakotina, O. A. Tciupa, E. V. Puntus, T. A. Raskina, L. N. Shilova, T. V. Kropotina, O. B. Nesmeyanova, T. A. Popova, I. B. Vinogradova, E. A. Dokukina, A. V. Plotnikova, P. S. Pukhtinskaia, A. V. Zinkina-Orikhan, Yu. N. Linkova, A. V. Eremeeva, A. A. Lutckii, E. L. Nasonov

“…However, continuation of LVL QW in those who not achieved DAS28-CRP≤2.6 at W24 induced ACR70 response in 37/75 (36.0%), DAS28-CRP remission in 35/75 (46.7%) and ACR/EULAR 2011 remission in 8/75 (10.7%) at W52.The most common adverse events (reported in ≥5% of subjects) were blood cholesterol increase (30.3%), ALT increase (23.0%), lymphocyte count decrease (17.1%), ANC decrease (16.4%). blood triglycerides increase (13.8%), bilirubin increase (11.2%), AST increase (9.9%), WBC decrease (9.9%), IGRA with Mycobacterium tuberculosis antigen positive (7.2%) and injection site reactions (5.9%). …”
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Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys by Jon C Emery, Peter J Dodd, Sayera Banu, Beatrice Frascella, Frances L Garden, Katherine C Horton, Shahed Hossain, Irwin Law, Frank van Leth, Guy B Marks, Hoa Binh Nguyen, Hai Viet Nguyen, Ikushi Onozaki, Maria Imelda D Quelapio, Alexandra S Richards, Nabila Shaikh, Edine W Tiemersma, Richard G White, Khalequ Zaman, Frank Cobelens, Rein MGJ Houben

“…Background: Individuals with bacteriologically confirmed pulmonary tuberculosis (TB) disease who do not report symptoms (subclinical TB) represent around half of all prevalent cases of TB, yet their contribution to Mycobacterium tuberculosis (Mtb) transmission is unknown, especially compared to individuals who report symptoms at the time of diagnosis (clinical TB). …”
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Whole genome sequencing improves the discrimination between Mycobacterium bovis strains on the southern border of Kruger National Park, South Africa by Eduard O. Roos, Johannes Loubser, Tanya J. Kerr, Anzaan Dippenaar, Elizma Streicher, Francisco Olea-Popelka, Suelee Robbe-Austerman, Tod Stuber, Peter Buss, Lin-Mari de Klerk-Lorist, Robin M. Warren, Paul D. van Helden, Sven D.C. Parsons, Michele A. Miller

“…Background: Mycobacterium bovis forms part of the Mycobacterium tuberculosis complex and has an extensive host range and zoonotic potential. …”
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Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis by David A. Barr, Charlotte Schutz, Avuyonke Balfour, Muki Shey, Mireille Kamariza, Carolyn R. Bertozzi, Timothy J. de Wet, Ryan Dinkele, Amy Ward, Kathryn A. Haigh, Jean-Paul Kanyik, Valerie Mizrahi, Mark P. Nicol, Robert J. Wilkinson, David G. Lalloo, Digby F. Warner, Graeme Meintjes, Gerry Davies

“…Summary: Background: Despite being highly prevalent in hospitalised patients with severe HIV-associated tuberculosis (TB) and sepsis, little is known about the mycobacteriology of Mycobacterium tuberculosis bloodstream infection (MTBBSI). We developed methods to serially measure bacillary load in blood and used these to characterise MTBBSI response to anti-TB therapy (ATT) and relationship with mortality. …”
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Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study by Jean David Pommier, MD, Chris Gorman, PhD, Yoann Crabol, MD, Kevin Bleakley, PhD, Heng Sothy, MD, Ky Santy, MD, Huong Thi Thu Tran, MD, Lam Van Nguyen, MD, Em Bunnakea, MD, Chaw Su Hlaing, MD, Aye Mya Min Aye, MD, Julien Cappelle, DVM, Magali Herrant, PhD, Patrice Piola, MD, Bruno Rosset, Veronique Chevalier, DVM, Arnaud Tarantola, MD, Mey Channa, MD, Jerome Honnorat, MD, Anne Laure Pinto, MSc, Sayaphet Rattanavong, MD, Manivanh Vongsouvath, MD, Mayfong Mayxay, MD, Sommanikhone Phangmanixay, MD, Khounthavy Phongsavath, MD, Ommar Swe Tin, MD, Latt Latt Kyaw, MD, Htay Htay Tin, MD, Kyaw Linn, MD, Thi Mai Hung Tran, MPH, Philippe Pérot, PhD, Nguyen Thi Thu Thuy, PhD, Nguyen Hien, MD, Phuc Huu Phan, MD, Philippe Buchy, MD, Philippe Dussart, PharmD, Denis Laurent, PharmD, Marc Eloit, DVM, Audrey Dubot-Pérès, PhD, Olivier Lortholary, MD, Xavier de Lamballerie, MD, Paul N Newton, FRCP, Marc Lecuit, Prof, Philippe Buchy, Em Bunnakea, Julien Cappelle, Mey Channa, Veronique Chevalier, Yoann Crabol, Xavier de Lamballerie, Audrey Dubot-Pérès, Philippe Dussart, Marc Eloit, Chris Gorman, Magali Herrant, Nguyen Hien, Chaw Su Hlaing, Jérôme Honnorat, Tran Thi Mai Hung, Tran Thi Thu Huong, Latt Latt Kyaw, Nguyen Van Lam, Denis Laurent, Marc Lecuit, Kyaw Linn, Olivier Lortholary, Mayfong Mayxay, Aye Mya Min Aye, Paul Newton, Philippe Perot, Sommanikhone Phangmanixay, Khounthavy Phongsavath, Phan Huu Phuc, Anne-Laurie Pinto, Patrice Piola, Jean-David Pommier, Sayaphet Rattanavong, Bruno Rosset, Ky Santy, Heng Sothy, Arnaud Tarantola, Nguyen Thi Thu Thuy, Htay Htay Tin, Ommar Swe Tin, Manivanh Vongsouvath, Pham Nhat An, Dang Duc Anh, Pascal Bonnet, Kimrong Bun, Danoy Chommanam, Viengmon Davong, Patrice Debré, Jean-François Delfraissy, Christian Devaux, Anousone Douangnouvong, Veasna Duong, Benoit Durand, Chanreaksmey Eng, Catherine Ferrant, Didier Fontenille, Lukas Hafner, Le Thanh Hai, Do Thu Huong, Marc Jouan, May July, Magali Lago, Jean-Paul Moatti, Bernadette Murgue, Khin Yi Oo, MengHeng Oum, Khansoudaphone Phakhounthong, Anh Tuan Pham, Do Quyen, Malee Seephonelee, Maud Seguy, Bountoy Sibounheunang, Kanarith Sim, Luong Minh Tan, Cho Thair, Win Thein, Phung Bich Thuy, Hervé Tissot-Dupont, Malavanh Vongsouvath

“…A confirmed or probable cause of encephalitis was identified in 425 (64%) patients: 216 (33%) of 664 cases were due to Japanese encephalitis virus, 27 (4%) were due to dengue virus, 26 (4%) were due to influenza virus, 24 (4%) were due to herpes simplex virus 1, 18 (3%) were due to Mycobacterium tuberculosis, 17 (3%) were due to Streptococcus pneumoniae, 17 (3%) were due to enterovirus A71, 74 (9%) were due to other pathogens, and six (1%) were due to autoimmune encephalitis. …”
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ESI-MS assay of M. tuberculosis cell wall antigen 85 enzymes permits substrate profiling and design of a mechanism-based inhibitor. by Barry, C, Backus, K, Barry, C, Davis, B

“…Mycobacterium tuberculosis Antigen 85 enzymes are vital to the integrity of the highly impermeable cell envelope and are potential therapeutic targets. …”

Why don’t we have an effective tuberculosis vaccine yet? by Davenne, T, McShane, H

“…Mycobacterium tuberculosis (M.tb) has co-evolved with humans for thousands of years, to cause tuberculosis (TB). …”

Towards new TB vaccines by Brazier, B, McShane, H

“…Mycobacterium tuberculosis remains the leading cause of death attributed to a single infectious organism. …”

Enhanced immunogenicity of Mycobacterium bovis BCG through CRISPRi mediated depletion of AftC by Bala T.S.A. Madduri, Lauren Allen, Stephen C. Taylor, Gurdyal S. Besra, Luke J. Alderwick

“…Mycobacterium tuberculosis causes the disease tuberculosis and affects a third of the world’s population. …”
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Application of Bacteriophages for Mycobacterial Infections, from Diagnosis to Treatment by Christopher G. Shield, Benjamin M. C. Swift, Timothy D. McHugh, Rebekah M. Dedrick, Graham F. Hatfull, Giovanni Satta

“…Mycobacterium tuberculosis and other non-tuberculous mycobacteria are responsible for a variety of different infections affecting millions of patients worldwide. …”
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Identification of antigens presented by MHC for vaccines against tuberculosis by Bettencourt, P, Müller, J, Nicastri, A, Cantillon, D, Madhavan, M, Charles, PD, Fotso, CB, Wittenberg, R, Bull, N, Pinpathomrat, N, Waddell, SJ, Stylianou, E, Hill, AVS, Ternette, N, McShane, H

“…Mycobacterium tuberculosis (M.tb) is responsible for more deaths globally than any other pathogen. …”

¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. by Beste, D, Bonde, B, Hawkins, N, Ward, J, Beale, M, Noack, S, Nöh, K, Kruger, N, Ratcliffe, R, McFadden, J

“…Mycobacterium tuberculosis requires the enzyme isocitrate lyase (ICL) for growth and virulence in vivo. …”